COPD: osteoporosis and sarcopenia

Majid, Hafsa; Kanbar-Agha, Faisal; Sharafkhaneh, Amir

doi:10.1186/s40749-016-0019-0

Cited by 8 publications

(8 citation statements)

References 227 publications

(230 reference statements)

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“…COPD itself is an independent risk factor for osteoporosis, and increases the likelihood of osteoporosis by an odds ratio of 2.6–2.83 [ 4 , 14 ] compared to age matched control subjects. Existing data points to the inflammatory milieu in COPD as the main factors that promotes imbalances in normal bone homeostasis, ultimately leading to osteoporosis: elevated levels of receptor activator of nuclear-factor kappa-B (RANK) and RANK/osteoprotegerin (OPG) ratio, increased interleukin-1 (IL-1), and tumor necrosis factor-α (TNF-α) [ 15 ]. Additionally, the use of inhaled corticosteroids, vitamin D deficiency, and hypogonadism seems to contribute to the increased predisposition [ 15 ].…”

Section: Discussionsupporting

confidence: 91%

“…Further, this study showed that sarcopenia is an independent risk factor of a decreased BMD regardless of bodyweight. The presence of sarcopenia seems to be additive to the baseline increased risk of osteoporosis among COPD patients [ 15 ]. The consequential effects on bones, skeletal muscle loss and dysfunction were all linked to persistent chronic inflammatory response in COPD [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…The consequential effects on bones, skeletal muscle loss and dysfunction were all linked to persistent chronic inflammatory response in COPD [ 16 ]. Our study also observed a significant reduction in muscle strength (HGS) and body composition indices (FFMI, ALM) in the osteoporotic group, and a positive correlation between body composition indices and BMD, all of which were consistent with studies showing interrelationships between components of sarcopenia and osteoporosis [ 10 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Association of sarcopenia with osteoporosis in patients with chronic obstructive pulmonary disease

Chua

Tee

2020

Osteoporosis and Sarcopenia

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of sarcopenia with osteoporosis in patients with chronic obstructive pulmonary disease

Chua

Tee

2020

Osteoporosis and Sarcopenia

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“…20 The fracture risk depends on bone strength, which is determined by bone mineral density (BMD) (determined by peak bone mass and amount of bone loss) and bone quality (a function of bone architecture, turnover, damage accumulation and mineralization). 21 It is generally accepted that BMD accounts for approximately 70% of bone strength. 22 In COPD patients, bone quality is impaired (low trabecular bone score with increased cortical porosity) and is associated with low bone turnover.…”

Section: Methodsmentioning

confidence: 99%

Musculoskeletal Disorders in Chronic Obstructive Airway Diseases: A Neglected Clinical Entity

Rao

Singh

Maikap

et al. 2021

MJR

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Chronic obstructive pulmonary disease (COPD) is a lung disease that can affect various extra-pulmonary organs; one being the musculoskeletal system. Skeletal muscle dysfunction and osteoporosis are two important musculoskeletal disorders that have an impact on the quality of life in COPD patients in terms of morbidity and mortality. Treatment related adverse effects of COPD such as steroid-induced myopathy and osteoporosis are well recognised. Other comorbidities like sarcopenia, cardiovascular disease, metabolic diseases (diabetes mellitus, obesity, and thyroid diseases), chronic kidney disease, sleep apnoea, anaemia, and depression are also noted, which can contribute to impaired health status, increased healthcare utilisation, and even mortality. As well, it has been shown that autoimmunity and autoimmune rheumatic diseases (AIRDs) are linked to COPD. In this mini-review, we intend to give an overview of different types of musculoskeletal disorders associated with COPD.

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“…Comorbid conditions that hinder wound healing and skin health are common among COPD patients, including malnutrition, decreased physical activity and systemic inflammation. [10][11][12] Additionally, it should be noted that certain medications employed in the management of COPD, specifically corticosteroids, have potential to compromise the integrity of the epidermis and impede the healing of wounds. 13 The objective of this research was to evaluate the effects of double bronchodilators in conjunction with triple inhalation therapy on minor lesion healing and skin integrity in patients with stable COPD.…”

Section: Introductionmentioning

confidence: 99%

Incidence and Management of Skin Lesions and Minor Wounds in Chronic Obstructive Pulmonary Disease Patients undergoing Advanced Bronchodilator Therapy

Shi,

Zhang

2024

International Wound Journal

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While triple inhalation therapy is commonly employed in the treatment of chronic obstructive pulmonary disease (COPD), limited knowledge exists regarding its impact on the healing of minor wounds and integrity of the epidermis. This study investigated the impact of combining triple inhalation therapy with double bronchodilators on the aforementioned parameters in patients with stable COPD. A cross‐sectional study was conducted in Changzhou, China, from March 2022 to October 2023, involving 540 patients who had received the diagnosis of stable COPD. Combined therapy participation requirements stipulated a minimum of 6 months of uninterrupted treatment. Dermatological examinations, demographic data and clinical records were utilized to collect information regarding the elasticity, moisture content and duration of wound healing. The research revealed that there were no statistically significant differences in demographic and clinical characteristics between the groups that received triple inhalation alone and triple inhalation in combination with double bronchodilators (p > 0.05). Nevertheless, the combined therapy group demonstrated shorter duration since receiving a diagnosis of COPD (p < 0.05). It is noteworthy to remark that the combined therapy group exhibited significantly higher skin moisture content and shorter interval for wound recovery when compared with the group that only received triple inhalation (p < 0.05). Lung function measurements in combined therapy group indicated enhanced Forced expiratory volume in the first second (FEV1) and FEV1/forced vital capacity ratio, as well as a reduction in COPD exacerbations. Nevertheless, no statistically significant distinction in skin elasticity was observed among the groups (p > 0.05). The supplementary application of triple inhalation therapy and double bronchodilators in stable COPD patients not only improved respiratory outcomes but also positively impacted skin health, specifically by promoting wound healing and augmenting moisture levels. These results highlighted the possible benefits of implementing a holistic treatment approach in COPD, suggesting that incorporating these therapies could offer additional advantages to the epidermis.

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COPD: osteoporosis and sarcopenia

Cited by 8 publications

References 227 publications

Association of sarcopenia with osteoporosis in patients with chronic obstructive pulmonary disease

Association of sarcopenia with osteoporosis in patients with chronic obstructive pulmonary disease

Musculoskeletal Disorders in Chronic Obstructive Airway Diseases: A Neglected Clinical Entity

Incidence and Management of Skin Lesions and Minor Wounds in Chronic Obstructive Pulmonary Disease Patients undergoing Advanced Bronchodilator Therapy

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