COPD – do the right thing

Sandelowsky, Hanna; Weinreich, Ulla Møller; Sundh, Josefin; Høines, Kristian Jong; Stratelis, Georgios; Løkke, Anders; Janson, Christer; Jensen, Christian

doi:10.1186/s12875-021-01583-w

“…O que está em conformidade com o estudo realizado por Varmaghani et al (2019), o qual evidenciou que a DPOC atinge principalmente a população idosa, com destaque para os que possuem mais de 65 anos, podendo ser justificado pelo fato de o VEF1 diminuir de forma gradual ao longo da vida. Dessa forma, a idade avançada é considerada um fator de risco para o desenvolvimento de DPOC (Sandelowsky et al, 2021).…”

Section: Discussionunclassified

“…Dentro da avaliação de gravidade, nenhum (0%) paciente possuía um GOLD leve, sendo a maior parte considerada grave ou muito grave. Dessa forma, deve-se ter um olhar especial para esses pacientes, visto que declínios progressivos do VEF1 estão diretamente ligados ao maior risco de hospitalizações, doenças cardiovasculares, exacerbações adicionais e, consequentemente, maior risco de mortalidade pela DPOC (Mouronte-Roibás et al, 2016;SAndelowsky et al, 2021).…”

Section: Discussionunclassified

Perfil Clínico-epidemiológico de pacientes com Doença Pulmonar Obstrutiva Crônica de um Centro de Referência de Alagoas: um estudo transversal

Pascoal

¹

,

Araujo²,

Paiva³

et al. 2022

RSD

1

0

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Objetivo: Caracterizar o perfil clínico-epidemiológico – com base em parâmetros de capacidade respiratória funcional, dispneia, gravidade e características sociodemográficas – dos pacientes com DPOC acompanhados em um centro de referência em pneumologia de Alagoas. Metodologia: Trata-se de um estudo observacional e transversal, pautado na aplicação de questionário padronizado – Modified British Medical Research Council (mMRc), avaliação de prontuário e espirometria de pacientes previamente diagnosticados com DPOC no setor de Pneumologia do Hospital Universitário Professor Alberto Antunes (HUPAA). Resultados: Um total de 46 pacientes foram analisados obtendo-se um perfil de idosos do sexo feminino (63%) que possuíram ou possuem hábitos tabágicos (78,3%) e outras comorbidades, prevalentemente, de origem cardiovascular. Para avaliar a escala do Global Initiative for Chronic Obstructive Lung Disease (GOLD) dos pacientes, o mMRC foi aplicado em conjunto com o número de exacerbações anuais da doença e classificados em A (52%), B (19,5%), C (2,1%) ou D (26%). Quanto a gravidade da doença, o Valor Expiratório Forçado no Primeiro Segundo (VEF1) esteve menor que 50% do valor predito em mais de 70% dos pacientes, com isso, considerados grave ou muito grave. Conclusão: O perfil epidemiológico dos pacientes enquadra-se aos estudos mundiais, com exceção da prevalência de mulheres em detrimento dos homens. Os pacientes possuem, relativamente, uma média qualidade de vida pautando-se pelo mMRC. Por outro lado, quanto a gravidade da doença, tem-se destaque para os pacientes com DPOC grave e muito grave.

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“…Dyspnea is the main symptom of COPD and the most frequent reason why COPD patients seek medical attention. 10 At the onset of COPD, timely intervention to relieve symptoms and exacerbations can prevent an acute decline in lung function and progression of the condition to severe emphysema. 11 Current treatments of COPD involve long-term inhalation therapy with bronchodilators, corticosteroids, or a combination of these agents.…”

Section: Introductionmentioning

confidence: 99%

Identification of Dysregulated Mechanisms and Candidate Gene Markers in Chronic Obstructive Pulmonary Disease

Lin¹,

Xue²,

Su³

et al. 2022

COPD

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Purpose This study aimed to identify candidate gene markers that may facilitate chronic obstructive pulmonary disease (COPD) diagnosis and treatment. Methods The GSE47460 and GSE151052 datasets were analyzed to identify differentially expressed mRNAs (DEmRs) between COPD patients and controls. DEmRs that were differentially expressed in the same direction in both datasets were analyzed for functional enrichment and for coexpression. Genes from the largest three modules were tested for their ability to diagnose COPD based on the area under the receiver operating characteristic curve (AUC). Genes with AUC > 0.7 in both datasets were used to perform regression based on the “least absolute shrinkage and selection operator” in order to identify feature genes. We also identified differentially expressed miRNAs (DEmiRs) between COPD patients and controls using the GSE38974 dataset, then constructed a regulatory network. We also examined associations between feature genes and immune cell infiltration in COPD, and we identified methylation markers of COPD using the GSE63704 dataset. Results A total of 1350 genes differentially regulated in the same direction in the GSE47460 and GSE151052 datasets were found. The genes were significantly enriched in immune-related biological functions. Of 186 modules identified using MEGENA, the largest were C1_ 6, C1_ 3, and C1_ 2. Of the 22 candidate genes screened based on AUC, 11 feature genes emerged from analysis of a subset of GSE47460 data, which we validated using another subset of GSE47460 data as well as the independent GSE151052 dataset. Feature genes correlated significantly with infiltration by immune cells. The feature genes GPC4 and RS1 were predicted to be regulated by miR-374a-3p. We identified 117 candidate methylation markers of COPD, including PRRG4. Conclusion The feature genes we identified may be potential diagnostic markers and therapeutic targets in COPD. These findings provide new leads for exploring disease mechanisms and targeted treatments.

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“…Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by persistent respiratory symptoms and airflow restriction. Exposure to tobacco smoke and air pollutants has been found to be responsible for the abnormalities found in the airway and/or alveolus [1][2][3][4]. Epidemiological studies showed that COPD has already become the 3rd most common cause of mortality worldwide [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effect of Endurance Training in COPD Patients Undergoing Pulmonary Rehabilitation: A Meta-Analysis

Li

¹

,

Wu

²

,

Wang

³

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. The efficacy of endurance training (ET) on patients with chronic obstructive pulmonary disease (COPD) has been controversial. This study was aimed at meta-analyzing the effect of ET in COPD patients undergoing pulmonary rehabilitation. Methods. The literature retrieval was performed in databases to screen relevant literature. Inclusion criteria were as follows: (1) subjects—COPD patients; (2) inclusion of interventional and control groups; (3) intervention measures—the interventional group received whole-body ET and other lung rehabilitation training, while the control group did not receive intervention or other lung rehabilitation training; (4) outcome indicators which included at least one of the following—6MWD, modified Medical Research Council questionnaire (mMRC), and COPD Assessment Test (CAT); and (5) study type—randomized controlled trials (RCTs). The Cochrane risk-of-bias tool was used to assess the risk of bias. The chi-square test was used to evaluate the magnitude of heterogeneity. Subgroup analysis was used to explore the source of heterogeneity. A funnel plot and Egger’s test were used to evaluate publication bias. Results. The 6MWD in the ET group was significantly higher than that in the control group ( MD = 47.20 , 95% CI [28.60, 65.79], P < 0.00001 ). Significant heterogeneity ( P < 0.00001 , I 2 = 76 % ) without publication bias ( P > 0.05 ) was noted. Subgroup analysis showed that the 6MWD of the ET group was significantly larger than that of the control group without heterogeneity ( P = 0.63 , I 2 = 0 % ; P = 0.59 , I 2 = 0 % ) in both the no training subgroup ( MD = 79.26 , 95% CI [72.69, 85.82], P < 0.00001 ) and other rehabilitation training group ( MD = 23.64 , 95% CI [6.70, 40.57], P = 0.006 ). The mMRC score ( MD = − 0.72 , 95% CI [-1.09, -0.34], P = 0.002 ) and CAT ( MD = − 6.07 , 95% CI [-7.28, -4.87], P < 0.00001 ) of the ET group were significantly lower than those of the control group. There was no heterogeneity ( P = 0.32 , I 2 = 15 % ; P = 0.16 , I 2 = 41 % ). Conclusion. ET can improve patients’ motor function and reduce dyspnea. ET might be incorporated as an important part of lung rehabilitation training.

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COPD – do the right thing

Cited by 38 publications

References 187 publications

Perfil Clínico-epidemiológico de pacientes com Doença Pulmonar Obstrutiva Crônica de um Centro de Referência de Alagoas: um estudo transversal

Perfil Clínico-epidemiológico de pacientes com Doença Pulmonar Obstrutiva Crônica de um Centro de Referência de Alagoas: um estudo transversal

Identification of Dysregulated Mechanisms and Candidate Gene Markers in Chronic Obstructive Pulmonary Disease

Effect of Endurance Training in COPD Patients Undergoing Pulmonary Rehabilitation: A Meta-Analysis

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