COPD and muscle loss: is blood flow restriction a potential treatment?

Thiebaud, Robert S.; Loenneke, Jeremy P.; Abe, Takashi

doi:10.17338/trainology.3.1_1

Cited by 6 publications

(13 citation statements)

References 55 publications

(65 reference statements)

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“…All health professionals were provided with a study information sheet. Health professionals indicating interest in participating in the study were provided a link to an electronic site which included a consent form, a 3-min video summarising key BFRE training aspects ( Supplemental Material 1 ), a narrative review about potential of BFRE in COPD, 7 a survey to obtain demographic data and previous knowledge regarding BFRE training ( Supplemental Material 2 ), and the proposed date for the focus group/interview.…”

Section: A – Participant Recruitmentmentioning

confidence: 99%

“…It is hypothesised, during exercise, restriction of blood flow to exercising muscles results in local muscular hypoxia and increased metabolite load triggering physiological responses leading to increases in aerobic capacity 3 and muscle strength and hypertrophy. 2 , 6 This novel training modality has been suggested for use in people with chronic obstructive pulmonary disease (COPD), 7 but current evidence consists of a single case-study where BFRE training was experienced as part of a comprehensive pulmonary rehabilitation program. 8 However, exercise training is recommended as a core component of COPD management, 9 symptom burden can limit exercise performance of people with COPD.…”

Section: Introductionmentioning

confidence: 99%

“… 10 As a low-intensity approach, BFRE training may be an option for people with COPD who have difficulty performing traditional moderate- to high-intensity exercise required to achieve physiological benefits. 7 …”

Section: Introductionmentioning

confidence: 99%

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Title: Blood flow restricted exercise training: Perspectives of people with chronic obstructive pulmonary disease and health professionals

et al. 2021

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Objective This descriptive qualitative study explored perspectives of people with chronic obstructive pulmonary disease (COPD) and health professionals concerning blood flow restricted exercise (BFRE) training. Methods People living with COPD and health professionals (exercise physiologists, physiotherapists, and hospital-based respiratory nurses and doctors) participated in interviews or focus groups, which included information about BFRE training and a facilitated discussion of positive aspects, barriers and concerns about BFRE training as a possible exercise-based intervention. Sessions were audio-recorded, and transcript data analysed using inductive content analysis. Results Thirty-one people participated (people with COPD n = 6; health professionals n = 25). All participant groups expressed positive perceptions of BFRE as a potential alternative low-intensity exercise mode where health benefits might be achieved. Areas of overlap in perceived barriers and concerns included the need to address the risk of potential adverse events, suitability of training sites and identifying processes to appropriately screen potential candidates. Discussion While potential benefits were identified, concerns about determining who is safe and suitable to participate, delivery processes, health professional training and effects on a variety of health-related outcomes need to be addressed before implementation of BFRE training for people with COPD.

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Section: A – Participant Recruitmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Title: Blood flow restricted exercise training: Perspectives of people with chronic obstructive pulmonary disease and health professionals

et al. 2021

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“…The growth in practitioner use of BFR exercise in general strength and conditioning as well as rehabilitation settings has also facilitated research in clinical populations such as chronic obstructive pulmonary disorder, 11 end‐stage kidney disease, 12 ischemic heart disease, 13 and sporadic inclusion body myositis 14 . These clinical populations require numerous considerations to account for altered hemodynamic responses, co‐morbidities, and contraindications inherent to each individual condition when compared with healthy populations.…”

Section: Introductionmentioning

confidence: 99%

Is there rationale for the cuff pressures prescribed for blood flow restriction exercise? A systematic review

Clarkson

May

Warmington

2020

Scandinavian Med Sci Sports

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Background Blood flow restriction exercise has increasingly broad applications among healthy and clinical populations. Ensuring the technique is applied in a safe, controlled, and beneficial way for target populations is essential. Individualized cuff pressures are a favored method for achieving this. However, there remains marked inconsistency in how individualized cuff pressures are applied. Objectives To quantify the cuff pressures used in the broader blood flow restriction exercise literature, and determine whether there is clear justification for the choice of pressure prescribed. Methods Studies were included in this review from database searches if they employed an experimental design using original data, involved either acute or chronic exercise using blood flow restriction, and they assessed limb or arterial occlusion pressure to determine an individualized cuff pressure. Methodologies of the studies were evaluated using a bespoke quality assessment tool. Results Fifty‐one studies met the inclusion criteria. Individualized cuff pressures ranged from 30% to 100% arterial occlusion pressure. Only 7 out of 52 studies attempted to justify the individualized cuff pressure applied during exercise. The mean quality rating for all studies was 11.1 ± 1.2 out of 13. Conclusions The broader blood flow restriction exercise literature uses markedly heterogeneous prescription variables despite using individualized cuff pressures. This is problematic in the absence of any clear justification for the individualized cuff pressures selected. Systematically measuring and reporting all relevant acute responses and training adaptations to the full spectrum of BFR pressures alongside increased clarity around the methodology used during blood flow restriction exercise is paramount.

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“…Both BFR-RT and BFR-AT have been proposed as possible alternatives to more physically demanding exercise prescriptions in a range of clinical and chronic disease populations such as chronic obstructive pulmonary disorder (Thiebaud et al, 2014b), end-stage kidney disease (Clarkson et al, 2017a), ischemic heart disease (Madarame et al, 2013), and inclusion body myositis (Jorgensen et al, 2018). While the ability to maintain muscle mass and size with a reduction in musculoskeletal tissue loading appeals in many of these physically impaired populations, it has not translated into larger scale randomized controlled trials among these populations.…”

Section: Introductionmentioning

confidence: 99%

Chronic Blood Flow Restriction Exercise Improves Objective Physical Function: A Systematic Review

2019

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Background: Blood flow restriction or KAATSU exercise training is associated with greater muscle mass and strength increases than non-blood flow restriction equivalent exercise. Blood flow restriction exercise has been proposed as a possible alternative to more physically demanding exercise prescriptions (such as high-load/high-intensity resistance training) in a range of clinical and chronic disease populations. While the maintenance of muscle mass and size with reduced musculoskeletal tissue loading appeals in many of these physically impaired populations, there remains a disconnect between some of the desired clinical measures for chronic disease populations and those commonly measured in the literature examining blood flow restriction exercise. While strength does play a vital role in physical function, task-specific objective measures of physical function indicative of activities of daily living are often more clinically relevant and applicable for evaluating the success of medical and surgical interventions or monitoring age- and disease-related physical decline. Objective: To determine whether exercise interventions utilizing blood flow restriction are able to improve objective measures of physical function indicative of activities of daily living. Methods: A systematic search of Medline, Embase, CINAHL, SPORTDiscus, and Springer identified 13 randomized control trials utilizing an exercise intervention combined with blood flow restriction, while measuring at least one objective measure of physical function. Participants were ≥18 years of age. Systematic review of the literature and quality assessment of the included studies used the Cochrane Collaboration's tool for assessing risk bias. Results: Data from 13 studies with a total of 332 participants showed blood flow restriction exercise, regardless of modality, most notably increased performance on the 30 s sit-to-stand and timed up and go tests, and generally improved physical function on other tests including walking tests, variations of sit-to-stand tests, and balance, jumping, and stepping tests. Conclusions: From the evidence available, blood flow restriction exercise of multiple modalities improved objective measures of physical function indicative of activities of daily living.

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COPD and muscle loss: is blood flow restriction a potential treatment?

Cited by 6 publications

References 55 publications

Title: Blood flow restricted exercise training: Perspectives of people with chronic obstructive pulmonary disease and health professionals

Title: Blood flow restricted exercise training: Perspectives of people with chronic obstructive pulmonary disease and health professionals

Is there rationale for the cuff pressures prescribed for blood flow restriction exercise? A systematic review

Chronic Blood Flow Restriction Exercise Improves Objective Physical Function: A Systematic Review

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