COPD and gender differences: an update

Aryal, Shambhu; Diaz-Guzman, Enrique; Mannino, David M.

doi:10.1016/j.trsl.2013.04.003

Cited by 185 publications

(180 citation statements)

References 67 publications

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“…For COPD and asthma, effect estimates appeared to be larger in females than in males, although sex differences were not statistically significant. With respect to COPD, this might be consistent with the observation that females appear to be more susceptible to COPD than males [34] but the causality certainly needs to be proved. Whereas our findings for asthma are novel, the results for COPD are in line with previous findings in case-control [14][15][16][17] and population-based studies [18].…”

Section: Discussionsupporting

confidence: 78%

Telomere length in circulating leukocytes is associated with lung function and disease

Albrecht¹,

Sillanpää²,

Karrasch³

et al. 2013

European Respiratory Journal

108

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Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function.Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and spirometric parameters (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC) of 12 595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex and smoking status.We observed negative associations between telomere length and asthma (b5 -0.0452, p50.024) as well as COPD (b5 -0.0982, p50.001), with associations being stronger and more significant when using GLI criteria than those of GOLD. In both diseases, effects were stronger in females than males. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p51.07610 -7 ), FVC (p52.07610 -5 ), and FEV1/FVC (p55.27610 -3 ). The effect was somewhat weaker in apparently healthy subjects than in COPD or asthma patients.Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases. @ERSpublicationsTelomere length is decreased in asthma and COPD patients and positively associated with spirometric indices

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Section: Discussionsupporting

confidence: 78%

Telomere length in circulating leukocytes is associated with lung function and disease

Albrecht¹,

Sillanpää²,

Karrasch³

et al. 2013

European Respiratory Journal

108

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“…Differential treatment appears to be an appropriate strategy according to recent reviews examining the role of sex in health outcomes in PR. 32,33 In this study, several staff members discussed women's apprehension regarding exercise and the need for more encouragement to initiate exercise within PR, which was viewed as being different from most men. In contrast, several staff members indicated that men were more likely to approach exercise in an aggressive manner (ie, initiate exercise at relative high intensities with reckless abandon).…”

Section: Discussionmentioning

confidence: 99%

A Qualitative Exploration of Exercise Among Pulmonary Rehabilitation Participants: Insight From Multiple Sources of Social Influence

Witcher

McGannon

Hernández³

et al. 2015

Respir Care

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BACKGROUND: Exercise training within the pulmonary rehabilitation (PR) context is considered the most effective strategy to reduce COPD symptoms. However, participation in PR and continued exercise training following program completion are low. Previous research examined factors related to attendance and adherence, but the knowledge base to date has been limited to quantitative findings that focus solely on participants diagnosed with COPD. In addition to quantitative research, exploring multiple perspectives (eg, PR participants, significant others, staff, and stakeholders) using qualitative research methods opens a window of additional understanding. The goal of this study was to obtain multiple perspectives on PR to gain insight into factors that affect exercise participation among individuals diagnosed with COPD. METHODS: A total of 26 participants were interviewed via telephone, including 8 individuals diagnosed with COPD (4 men and 4 women, mean age of 67 [range of 58 -77] y), 4 family members, 11 PR staff, and 3 community stakeholders. RESULTS: Analysis revealed 3 themes: task self-efficacy for exercise, provision of support and encouragement, and perceptions of gender differences. Despite initial concerns, individuals diagnosed with COPD reported becoming more confident during PR and emphasized the importance of being supported by staff. PR staff perceived that men tended to approach exercise in a more eager and aggressive manner compared with women, who were more cautious and hesitant. CONCLUSIONS: In addition to enhancing task self-efficacy, findings suggest that exercise participation and adherence within the PR environment may be improved by adopting a gender-tailored approach.

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“…This could be due to the smoking trends some decades ago. However, the historical perception that COPD is a predominantly disease of males is changing, because of changing smoking trends during the past 50 years [21]. In addition, a study in community-dwelling dependent elderly concluded that women had a higher rate of living alone and a lower rate of receiving care by a spouse [22].…”

Section: Impact On Informal Caregiversmentioning

confidence: 99%

Informal caregivers of patients with COPD: Home Sweet Home?

et al. 2015

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The burden of chronic obstructive pulmonary disease (COPD) on society is increasing. Healthcare systems should support patients with COPD in achieving an optimal quality of life, while limiting the costs of care. As a consequence, a shift from hospital care to home care seems inevitable. Therefore, patients will have to rely to a greater extent on informal caregivers. Patients with COPD as well as their informal caregivers are confronted with multiple limitations in activities of daily living. The presence of an informal caregiver is important to provide practical help and emotional support. However, caregivers can be overprotective, which can make patients more dependent. Informal caregiving may lead to symptoms of anxiety, depression, social isolation and a changed relationship with the patient. The caregivers' subjective burden is a major determinant of the impact of caregiving. Therefore, the caregiver's perception of the patient's health is an important factor. This article reviews the current knowledge about these informal caregivers of patients with COPD, the impact of COPD on their lives and their perception of the patient's health status. @ERSpublications Informal caregivers play important roles: their needs should be part of research and clinical care for COPD patients http://ow.ly/PSl7F

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COPD and gender differences: an update

Cited by 185 publications

References 67 publications

Telomere length in circulating leukocytes is associated with lung function and disease

Telomere length in circulating leukocytes is associated with lung function and disease

A Qualitative Exploration of Exercise Among Pulmonary Rehabilitation Participants: Insight From Multiple Sources of Social Influence

Informal caregivers of patients with COPD: Home Sweet Home?

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