Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology

Trindade, Rafaela da; Silva, Joyce Kelly R. da; Setzer, William N.

doi:10.3390/ijms19051511

Cited by 89 publications

(119 citation statements)

References 107 publications

(103 reference statements)

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“…In this context, copaiba has been one of the most important Brazilian medicinal plants [1][2][3][4][5][6]. As early as 1587, the Portuguese explorer and naturalist Gabriel Soares de Sousa described the use of copaiba oleoresin for healing arrow wounds [2].…”

Section: Introductionmentioning

confidence: 99%

“…Copaiba trees belong to the genus Copaifera, family Fabaceae, and subfamily Caesalpinioideae [6]. There are more than 70 Copaifera species distributed worldwide, with widespread occurrence in Central and South America, but also in West Africa and Asia [6]. Brazil has the greatest biodiversity of Copaifera with 26 species and 8 varieties [6].…”

Section: Introductionmentioning

confidence: 99%

“…There are more than 70 Copaifera species distributed worldwide, with widespread occurrence in Central and South America, but also in West Africa and Asia [6]. Brazil has the greatest biodiversity of Copaifera with 26 species and 8 varieties [6]. The most abundant species are Copaifera multijuga Hayne, Copaifera reticulata, and Copaifera langsdorffii Desf.…”

Section: Introductionmentioning

confidence: 99%

“…The most abundant species are Copaifera multijuga Hayne, Copaifera reticulata, and Copaifera langsdorffii Desf. [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…The oleoresin is the most important economic and medicinal product of copaiba trees [6]. It is a transparent and colored exudate obtained from the trunks of the trees, with variable viscosity, and consisting of a nonvolatile fraction of diterpenes (20%) and a volatile fraction of sesquiterpenes (80%) [2,[5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Natural killer activity of the spleen cells of Ehrlich tumor-bearing mice treated with Copaifera multijuga extract

Rodrigues

Albiero

Nery

et al. 2019

Sci Med

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AIMS: Copaifera multijuga Hayne oleoresin is commonly used in traditional medicine owing to its anti-inflammatory, antiseptic, antitumor, and antibacterial properties. However, little is known about the effect of the compounds from the bark of this plant. In this study, the immunomodulatory effect of the ethanolic extract of C. multijuga bark via natural killer activity of non-adherent spleen cells of Ehrlich tumor-bearing mice was evaluated.METHODS: Male Swiss mice were inoculated subcutaneously with 1×106 Ehrlich tumor cells (Ehrlich and Ehrlich/C. multijuga group) or phosphate buffered saline solution (control group and C. multijuga group) and treated orally daily with C. multijuga extract (200 mg kg-1, 0.1 mL per mouse, for the Ehrlich/C. multijuga and C. multijuga groups) or phosphate buffered saline solution (control group and Ehrlich group). The four experimental groups consisted in eight mice each and were organized in two sets, one treated for seven days and another treated for 14 days, totalizing 64 mice throughout the experiment. Twenty-four hours after the last oral administration, the mice were euthanized and the spleen tissue was isolated to prepare a non-adherent spleen cell suspension and to evaluate natural killer activity. Data are presented as the cell lysis percentage of Yac.1 target cells by non-adherent spleen cells.RESULTS: Treatment for seven days increased natural killer activity in the Ehrlich/C. multijuga group (21.20±8.89, p<0.05) compared to the control group (3.14±2.71, p<0.05); however, this effect was not maintained in the groups treated for 14 days (Control: 6.02±6.98, Ehrlich: 4.82±7.72, C. multijuga: 2.07±2.10, Ehrlich/C. multijuga: 2.01±1.63, p>0.05).CONCLUSIONS: Treatment for seven days with an ethanolic extract of C. multijuga bark enhanced the natural killer activity of non-adherent spleen cells from Ehrlich tumor-bearing mice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The most abundant species are Copaifera multijuga Hayne, Copaifera reticulata, and Copaifera langsdorffii Desf. [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural killer activity of the spleen cells of Ehrlich tumor-bearing mice treated with Copaifera multijuga extract

Rodrigues

Albiero

Nery

et al. 2019

Sci Med

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Production of More Potent Anti‐Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans

Sousa

Teixeira

Freitas

et al. 2022

Chemistry & Biodiversity

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Candida species are responsible for causing invasive candidiasis with high mortality rate and their resistance to available antifungal drugs is a major clinical challenge. Biotransformation process of the labdane diterpene ent-labd-8( 17)-en-15,18-dioic acid (1) carried out with Cunninghamella elegans afforded five new derivatives (compounds 2-6). Unusual regioselective hydroxylation of the methyl group at the C-20 position of labdanetype diterpene was achieved and all compounds were subjected to cytotoxicity and antifungal evaluations. Compound 1 and its derivatives were not cytotoxic to normal (MCF-10A) and tumor (MCF-7) cell lines. Compounds 2 and 3 exhibited fungistatic activity against all tested Candida strains at lower concentrations than fluconazole. Both compounds also showed the strongest fungicidal activity against C. albicans, which is the most prevalent fungal agent involved in candidemia.

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Mathematical and numerical analyses of cellular, molecular and angiogenic parameters of a rat skin wound healing model

Oliveira

Gushiken

Pellizzon

et al. 2023

Numer Methods Biomed Eng

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The inflammatory phase is an important event in the skin wound healing process. The deposition of granulation tissue in the wound bed and the rebuilding of the vascular network occur as inflammation diminishes. An angiogenic component in the formation of granulation tissue is the secretion of vascular endothelial growth factor, which assists in the chemotaxis, proliferation, and replication of fibroblasts. In this paper, we develop a mathematical model of skin wound healing angiogenic factors based on inflammatory cells (macrophages and neutrophils) and mediators (interleukin 6 and interleukin 10). We highlight the importance of this process in vascular endothelial growth factor release and in the formation of new capillary tips. We used a mathematical model of partial differential equations based on the reaction‐diffusion‐advection equations. In order to calibrate the parameters, we considered an in vivo model composed by four treatments: hydroalcoholic extract and oil‐resin of Copaifera langsdorffii at 10% concentration, collagenase, and Lanette cream. Using the laboratory data for the wound edge, our mathematical model estimated the values of vascular endothelial growth factor concentration, and tips density in the center of the wound with a maximum error of 2.9%, and predicted healing time required for each treatment. The region of viability for the parameters, in the proposed model, was found through numerical simulations from the Interleukin 6 and 10 dysregulation and we obtained that, among the parameters analyzed, the greatest influencer in the dynamics of the system is the one, which represents the production of Interleukin 10 during phagocytosis.

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Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology

Cited by 89 publications

References 107 publications

Natural killer activity of the spleen cells of Ehrlich tumor-bearing mice treated with Copaifera multijuga extract

Natural killer activity of the spleen cells of Ehrlich tumor-bearing mice treated with Copaifera multijuga extract

Production of More Potent Anti‐Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans

Mathematical and numerical analyses of cellular, molecular and angiogenic parameters of a rat skin wound healing model

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