COP9 signalosome: Discovery, conservation, activity, and function

Qin, Nanxun; Xu, Dongqing; Li, Jigang; Deng, Xing Wang

doi:10.1111/jipb.12903

Cited by 77 publications

(71 citation statements)

References 109 publications

(163 reference statements)

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“…Upon light exposure, light signals and light-activated photoreceptors inhibit COP/DET/FUS activity through multiple molecular regulatory mechanisms (Hoecker, 2017;Podolec and Ulm, 2018). COP/DET/FUS proteins consist of three distinct biochemical entities: the COP1-SPA complex, the COP10-DET1-DNA DAMAGE BINDING PROTEIN1 (DDB1; CDD) complex, and the COP9 signalosome (CSN; Wei and Deng, 2003;Yanagawa et al, 2004;Zhu et al, 2008;Qin et al, 2020). The Arabidopsis genome encodes four SPA proteins (SPA1 to SPA4), and two COP1 and two SPA proteins form a stable core complex (Zhu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

COLD-REGULATED GENE27 Integrates Signals from Light and the Circadian Clock to Promote Hypocotyl Growth in Arabidopsis

et al. 2020

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Light and the circadian clock are two essential external and internal cues affecting seedling development. COLD-REGULATED GENE27 (COR27), which is regulated by cold temperatures and light signals, functions as a key regulator of the circadian clock. Here, we report that COR27 acts as a negative regulator of light signaling. COR27 physically interacts with the CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)-SUPPRESSOR OF PHYTOCHROME A1 (SPA1) E3 ubiquitin ligase complex and undergoes COP1-mediated degradation via the 26S proteasome system in the dark. cor27 mutant seedlings exhibit shorter hypocotyls, while transgenic lines overexpressing COR27 show elongated hypocotyls in the light. In addition, light induces the accumulation of COR27. On one hand, accumulated COR27 interacts with ELONGATED HYPOCOTYL5 (HY5) to repress HY5 DNA binding activity. On the other hand, COR27 associates with the chromatin at the PHYTOCHROME INTERACTING FACTOR4 (PIF4) promoter region and upregulates PIF4 expression in a circadian clock-dependent manner. Together, our findings reveal a mechanistic framework whereby COR27 represses photomorphogenesis in the light and provide insights toward how light and the circadian clock synergistically control hypocotyl growth.

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Section: Introductionmentioning

confidence: 99%

COLD-REGULATED GENE27 Integrates Signals from Light and the Circadian Clock to Promote Hypocotyl Growth in Arabidopsis

et al. 2020

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“…In the discovery of drugs targeting allergic diseases, phytochemicals have taken an important part such as galangin (16), chrysin (17) and chicoric acid (18). As the major phytochemical, irisflorentin was found in Belamcanda chinensis (9) and Iris leptophylla Lingelsh (10). Pharmacokinetic analysis has revealed after oral administration of irisflorentin 27.0 mg/kg in Belamcanda chinensis extract to rats, the maximum plasma concentration (C max ) was 29.9 ± 3.5 µg/mL, time to maximum concentration (T max ) was 0.25 ± 0.0 h, apparent elimination half-life time (t 1/2 ) was 3.48 ± 0.37 h, and area under the curve (AUC) was 52.42 ± 5.7 µg/Lh (19).…”

Section: Discussionmentioning

confidence: 99%

“…CELLS VIA REDUCING HISTAMINE RELEASE AND PRODUCTION OF PRO-INFLAMMATORY CYTOKINES Irisflorentin (Fig. 1) is an isoflavonoid found in Belamcanda chinensis (9) and Iris leptophylla Lingelsh (10). Previous pharmacological investigations have shown irisflorentin affords neuroprotection (11) and anti-inflammation (12).…”

Section: Irisflorentin Suppresses Allergic Inflammation In Mastmentioning

confidence: 99%

Irisflorentin suppresses allergic inflammation in mast cells via reducing histamine release and production of pro-inflammatory cytokines

Li¹,

Meng²

2019

Acta Poloniae Pharmaceutica - Drug Research

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Allergic diseases afflict many people worldwide. Allergic inflammation encompassing acute allergic reaction and chronic inflammatory response is the major pathogenesis. To discovery novel therapeutic approach for allergic diseases, we have evaluated the anti-allergic inflammatory effects of irisflorentin using RBL-2H3 cells. The results showed certain concentrations of irisflorentin could suppress histamine release and secretion of TNF-α, IL-1β and IL-6. Further investigations indicated that the effects of irisflorentin were associated with a reduction of intracellular calcium, suppression of NF-κB signaling pathway and inhibition of caspase-1 activity. Therefore, the results of the current study demonstrated that irisflorentin can ameliorate mast cell-mediated allergic inflammation. These results can provide evidence for the discovery of novel therapy for allergic diseases and application of irisflorentin in practice.

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“…During these two distinct developmental processes, a variety of biological factors, including multiple photoreceptors, E3 ubiquitin ligases, and transcriptional regulators, work in concert to determine the response to changing light conditions in plants (Lin and Wang. 2007;Quail 2007;Zhang et al 2007;Xu 2019;Qin et al 2020). Extensive studies have shown that BBXs act as transcription factors or transcriptional regulators and that they work in parallel and coordinate with other factors in light-controlled seedling development (Table 1, Figure 2).…”

Section: Involvement Of Bbx In the Regulation Of Photomorphogenesismentioning

confidence: 99%

B‐box proteins: Pivotal players in light‐mediated development in plants

Song

Bian

Liu

et al. 2020

JIPB

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Light signals mediate a number of physiological and developmental processes in plants, such as flowering, photomorphogenesis, and pigment accumulation. Emerging evidence has revealed that a group of B‐box proteins (BBXs) function as central players in these light‐mediated developmental processes. B‐box proteins are a class of zinc‐coordinated transcription factors or regulators that not only directly mediate the transcription of target genes but also interact with various other factors to create a complex regulatory network involved in the precise control of plant growth and development. This review summarizes and highlights the recent findings concerning the critical regulatory functions of BBXs in photoperiodic flowering, light signal transduction and light‐induced pigment accumulation and their molecular modes of action at the transcriptional and post‐translational levels in plants

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COP9 signalosome: Discovery, conservation, activity, and function

Cited by 77 publications

References 109 publications

COLD-REGULATED GENE27 Integrates Signals from Light and the Circadian Clock to Promote Hypocotyl Growth in Arabidopsis

COLD-REGULATED GENE27 Integrates Signals from Light and the Circadian Clock to Promote Hypocotyl Growth in Arabidopsis

Irisflorentin suppresses allergic inflammation in mast cells via reducing histamine release and production of pro-inflammatory cytokines

B‐box proteins: Pivotal players in light‐mediated development in plants

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