Background: It is evident that leakage through pipelines, especially in areas where environmentally sensitive can cause many threats to the creatures that live on the earth. Methane gas has a relatively stronger effect on global warming than carbon dioxide thus the identification and prevention of long-term leaks is also of particular importance. Therefore, the current study was designed to estimate methane gas leaks from Mashhad gas risers and investigate the environmental and economic impacts.Methods: This study was conducted in the form of cross-sectional and aiming analytical-descriptive in all 8 town gas zones of Mashhad (2021). The total stages of this study include: 1) computing the numbers of town gas risers of Mashhad and their ground variables (longevity of risers, service and user type of riser, urban zones, and etc.). 2) Computing the number of risers which have leakage. 3) Determining the sample size and method of sampling. 4) Checking the relationship between leakage and equipment/risers’ connections. 5) Estimating the relationship between the service life of the riser and leakage. 6) Determining the relationship between leakage rate and service type of riser (household, industrial and commercial). 7) The relationship between leakage rate and urban zones. 8) Determining the leak rate of the riser in different seasons. 9) Calculating the rate of the economic cost caused by methane leak. 10) Evaluating the environmental aspects of the gas leak.Results: There was no significant difference between the riser type and leakage rate. However, there was a significant difference between the leakage rate of the riser and urban zones, leakage rate and season, and leakage rate and service life of the riser. According to the US Environmental Protection Agency (EPA), one molecule of methane will increase heating by 28 to 36 times more than one molecule of carbon dioxide over a period of 100 years. Another effect of global warming that can have an adverse effect is to increase the water requirement of plants. By realizing the fact that the service life of the riser, urban zones, and season directly affects methane gas leak, thus a significant amount of gas leakage can be prevented widely by controlling the above items: which demonstrate its effects on the environmental and economic aspects over a long time. Other hands, the direct Methane's effect is global warming and the most important indirect effects include economic, social, cultural and climate changes, extinction of animal species, and human diseases.