COP1 – from plant photomorphogenesis to mammalian tumorigenesis

Yi, Chunling; Deng, Xing Wang

doi:10.1016/j.tcb.2005.09.007

Cited by 302 publications

(336 citation statements)

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“…Among the repressors of photomorphogenesis, COP1 is a RING type E3 ubiquitin ligase that is evolutionarily conserved in many higher eukaryotes 4 . COP1 forms multiple complexes with SUPPRESSOR OF PHYA-105 (SPA1-4) family members 5 .…”

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CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1

et al. 2015

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Plants undergo contrasting developmental programs in dark and light. Photomorphogenesis, a light-adapted programme is repressed in the dark by the synergistic actions of CUL4 COP1-SPA E3 ubiquitin ligase and a subset of basic helix-loop-helix transcription factors called phytochrome interacting factors (PIFs). To promote photomorphogenesis, light activates the phytochrome family of sensory photoreceptors, which inhibits these repressors by poorly understood mechanisms. Here, we show that the CUL4 COP1-SPA E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis. The light-induced ubiquitylation and subsequent degradation of PIF1 is reduced in the cop1, spaQ and cul4 backgrounds. COP1, SPA1 and CUL4 preferentially form complexes with the phosphorylated forms of PIF1 in response to light. The cop1 and spaQ seeds display strong hyposensitive response to far-red light-mediated seed germination and light-regulated gene expression. These data show a mechanism by which an E3 ligase attenuates its activity by degrading its cofactor in response to light.

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CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1

et al. 2015

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“…4A, phyA,B/cry1,2 mutant seedlings produce short roots both in light and darkness, arguing against the possible involvement of photoreceptors besides PhyA, PhyB, Cry1, and Cry2 in the root growth response to light. To further investigate whether well established light-signaling cascades of these sensors are responsible for root elongation in the light (11,12), we used the mutant constitutive photomorphogenic1 (cop1-4). COP1 represses the default program of photomorphogenesis in darkness resulting in skotomorphogenesis.…”

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Photosynthetic sucrose acts as cotyledon-derived long-distance signal to control root growth during early seedling development in Arabidopsis

Kircher

Schöpfer

2012

Proc. Natl. Acad. Sci. U.S.A.

213

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The most hazardous span in the life of green plants is the period after germination when the developing seedling must reach the state of autotrophy before the nutrients stored in the seed are exhausted. The need for an economically optimized utilization of limited resources in this critical period is particularly obvious in species adopting the dispersal strategy of producing a large amount of tiny seeds. The model plant Arabidopsis thaliana belongs to this category. Arabidopsis seedlings promote root development only in the light. This response to light has long been recognized and recently discussed in terms of an organ-autonomous feature of photomorphogenesis directed by the red/blue light absorbing photoreceptors phytochrome and cryptochrome and mediated by hormones such as auxin and/or gibberellin. Here we show that the primary root of young Arabidopsis seedlings responds to an interorgan signal from the cotyledons and that phloem transport of photosynthesis-derived sugar into the root tip is necessary and sufficient for the regulation of root elongation growth by light.

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“…By reverse genetics, we have identified candidate genes to regulators of shade-avoidance responses; ATHB2 orthologs (Ciarbelli et al 2008), photomorphogenesis and seedling establishment; FHY3/FAR1, NDPK2, PIF/PIL family, PP7, RAP1/ ATMYC2, RFI2 (Shen et al 2005;Yadav et al 2005;Chen and Ni 2006;Lin et al 2007;Genoud et al 2008;Leivar et al 2008), light-regulated proteolysis; COP1, EID1, LAF1, SPA1 (Yi and Deng 2005;Marrocco et al 2006;Yang et al 2009;Chen et al 2010;Fankhauser and Ulm 2011) and developmental transitions; CO, PFT1 (Suárez-López et al 2001;Cerdán and Chory 2003) (Table S2). Using the obtained sequence information in a reverse genetics approach, we have identified a novel petunia mutant carrying a mutation in CCT (CO, CO-like, TOC1) domain (Strayer et al 2000;Valverde 2011).…”

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confidence: 99%

A reverse genetics approach identifies novel mutants in light responses and anthocyanin metabolism in petunia

Berenschot

Quecini

2013

Physiol Mol Biol Plants

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Flower color and plant architecture are important commercially valuable features for ornamental petunias (Petunia x hybrida Vilm.). Photoperception and light signaling are the major environmental factors controlling anthocyanin and chlorophyll biosynthesis and shadeavoidance responses in higher plants. The genetic regulators of these processes were investigated in petunia by in silico analyses and the sequence information was used to devise a reverse genetics approach to probe mutant populations. Petunia orthologs of photoreceptor, light-signaling components and anthocyanin metabolism genes were identified and investigated for functional conservation by phylogenetic and protein motif analyses. The expression profiles of photoreceptor gene families and of transcription factors regulating anthocyanin biosynthesis were obtained by bioinformatic tools. Two mutant populations, generated by an alkalyting agent and by gamma irradiation, were screened using a phenotype-independent, sequence-based method by high-throughput PCR-based assay. The strategy allowed the identification of novel mutant alleles for anthocyanin biosynthesis (CHALCONE SYNTHASE ) and regulation (PH4), and for light signaling (CONSTANS ) genes.

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COP1 – from plant photomorphogenesis to mammalian tumorigenesis

Cited by 302 publications

References 65 publications

CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1

CUL4 forms an E3 ligase with COP1 and SPA to promote light-induced degradation of PIF1

Photosynthetic sucrose acts as cotyledon-derived long-distance signal to control root growth during early seedling development in Arabidopsis

A reverse genetics approach identifies novel mutants in light responses and anthocyanin metabolism in petunia

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