Coordinatively Unsaturated Fe<sup>3+</sup> Based Activatable Probes for Enhanced MRI and Therapy of Tumors

Zhang, Peisen; Hou, Yi; Zeng, Jianfeng; Li, Yingying; Wang, Zihua; Zhu, Ran; Ma, Tiancong; Gao, Mingyuan

doi:10.1002/anie.201904880

Cited by 151 publications

(119 citation statements)

References 46 publications

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“…[ 41–43 ] In addition, Fe 3+ ion has a remarkable T 1 contrast enhancement effect. [ 44 ] Based on this, the Cu 2+ in PFP@Fe/Cu‐SS MOF can be used in T 1 ‐weighted MRI, while the Fe 3+ released by PFP@Fe/Cu‐SS MOF under the action of endogenous H 2 O 2 and/or GSH in tumor enhances its T 1 imaging ability. Therefore, the PFP@Fe/Cu‐SS MOF has the potential to be used in MRI imaging.…”

Section: Resultsmentioning

confidence: 99%

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Guo

et al. 2020

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Ferroptosis is attracting significant attention due to its effectiveness in tumor treatment. The efficiency to produce toxic lipid peroxides (LPOs) at the tumor site plays a key role in ferroptosis. A hybrid PFP@Fe/Cu‐SS metal organic framework (MOF) is synthesized and shown to increase intratumoral LPO content through redox reactions generating ·OH. In addition, glutathione (GSH) depletion through disulfide‐thiol exchange leads to the inactivation of glutathione peroxide 4 (GPX4), which results in a further increase in LPO content. This MOF exhibits high inhibitory effect on the growth of xenografted Huh‐7 tumors in mice. The coadministration of a ferroptosis inhibitor reduces the antitumor effect of the MOF, leading to a restoration of GPX4 activity and an increase in tumor growth. Moreover, the construction of Cu into mesoporous PFP@Fe/Cu‐SS not only allows the MOF to be used as a contrast agent for T1‐weighted magnetic resonance imaging, but also renders its photothermal conversion capacity. Thus, near‐infrared irradiation is able to induce photothermal therapy and transform the encapsulated liquid perfluoropentane into microbubbles for ultrasound imaging.

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Section: Resultsmentioning

confidence: 99%

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Guo

et al. 2020

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“…Metal ions play a crucial role in environmental and biological systems. Fe 3+ , one of the most essential transition metal ions, is indispensable for biochemical processes at cellular level . Excess and deficiency of Fe 3+ would impair biological systems seriously .…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Chen

Liu

et al. 2020

J of Applied Polymer Sci

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Amino-functionalized highly crosslinked organic-inorganic hybrid polyphosphazene microspheres were prepared via a one-pot polycondensation method and served as a fluorescent sensor for the detection of Fe 3+ in solution. With the introduction of p-phenylenediamine unites, the polyphosphazene microspheres could be endowed with fluorescent property and abundant active amino groups on the surface. The microspheres were further used as the fluorescent sensor for the detection of Fe 3+ . Fluorescence study showed high sensing sensitivity and selectivity of the microspheres, and the limit of detection was determined as 0.076 μM for Fe 3+ . Active amino groups on the surface could efficiently improve the detection sensitivity of Fe 3+ . Moreover, highly crosslinked organic-inorganic hybrid structure was beneficial to the photostability and thermostability, enabled the microspheres to be possible for constructing practicable sensors. This work is expected to inspire the design of advanced polyphosphazene-based fluorescent sensors for applications in analytical detection.

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“…Compared to GA molecules themselves, the OH stretching vibration band of Fe 2 O 3 @GA‐8 SPs is shifted from 3280 to 3401 cm −1 , suggesting that Fe 3+ is coordinated with GA moieties with intermolecular hydrogen bonding involved. [ 12 ] Besides, the characteristic peak of GA at 1025 cm −1 (OH in‐plane deformation) appears in the Fe 2 O 3 @GA‐8 SPs. [ 13 ] As demonstrated by the electrochemical characterization (Figure 6D), GA molecules have a distinct oxidation peak at 0.469 eV in citrate buffer solution (10 × 10 −3 m , pH 3.0), which is attributed to oxidization of the catechol group in GA. [ 14 ] Correspondingly, a weaker oxidation peak appears at 0.494 eV for Fe 2 O 3 @GA SPs.…”

Section: Resultsmentioning

confidence: 99%

Monodisperse Fe₂O₃ Supraparticles: Eco‐Friendly Fabrication, Gallic Acid Modification, Size‐Dependent Photothermal Conversion Efficiency, and Cellular Uptake

Ling

Gong

Xia

2020

Adv Materials Inter

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For example, soft-template fabrication is one of representative methods for various inorganic SPs, [4c,5] which however possess two typical problems of two-step fabrication systems. First of all, they need lots of organic solvents and surfactants, which inevitably results in environmental concerns. Then, monodispersity of the resultant products is often not ideal, causing some difficulty in their property studies and applications. [1b,6] To address these issues, we previously developed a self-limited strategy for onestep in situ fabricating various (CdS, CdSe, ZnS, PbS, Au@CdSe core@shell, etc.) SPs with narrow size distribution. [7] Because the SPs are self-assembled based on the intrinsic forces among the building blocks, any surfactants and organic solvents are completely needless. Correspondingly, the fabrication processes are carried out in 100% water solutions. Then, to be appropriate for biomedical applications, a few modified fabrication systems have been further explored for the corresponding SPs. [3c,d] Especially, we recently presented a urea modulated system for in situ fabricating citrate modified Fe 2 O 3 SPs. The products are quasi-amorphous, 15 nm in diameter, and have the capacities for active T 1-weighted magnetic resonance imaging (MRI) in vivo. [8] As a new-type of SPs, it is significant to well understand their fabrication approach, engineer their surface chemistry, as well as explore their new application potentials. In this study, we systematically study the eco-friendly fabrication system of the hierarchical Fe 2 O 3 SPs. First, by means of urea as pH modulator, monodisperse Fe 2 O 3 SPs with 7 to 90 nm in diameters can be one-step in situ self-assembled in 100% water solution. Then, in addition to citrate, it is found that the SPs can be fabricated by various carboxyl stabilizers, indicating the versatility of the proposed fabrication system. Third, by means of gallic acid (GA) modification, the corresponding products (denoted as Fe 2 O 3 @GA SPs) can be endowed nearinfrared light-absorbing properties and subsequent photothermal therapy potentials. Fourth, the Fe 2 O 3 @GA SPs exhibit size-dependent photothermal performances and cellular uptake. In terms of 8 nm sized Fe 2 O 3 @GA SPs, their photothermal conversion efficiency and cellular uptake are 66.63% and 8.4 pg Fe/cell, which are well higher than that of 25 and 47 nm sized products. In this study, the eco-friendly fabrication system of the hierarchical monodisperse Fe 2 O 3 supraparticles (SPs) is systematically studied. First, by means of urea as pH modulator, monodisperse Fe 2 O 3 SPs with 7 to 90 nm in diameters can be one-step in situ self-assembled in 100% water solution. Then, the SPs can be reliably fabricated by various carboxyl stabilizers, indicating the versatility of the proposed fabrication system. Third, by means of gallic acid (GA) modification, the corresponding products (denoted as Fe 2 O 3 @GA SPs) can be endowed near-infrared light-absorbing properties and photothermal therapy potentials. Fourth, the Fe 2 O 3 @GA ...

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Coordinatively Unsaturated Fe³⁺ Based Activatable Probes for Enhanced MRI and Therapy of Tumors

Cited by 151 publications

References 46 publications

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Monodisperse Fe₂O₃ Supraparticles: Eco‐Friendly Fabrication, Gallic Acid Modification, Size‐Dependent Photothermal Conversion Efficiency, and Cellular Uptake

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Coordinatively Unsaturated Fe3+ Based Activatable Probes for Enhanced MRI and Therapy of Tumors

Cited by 151 publications

References 46 publications

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe3+

Monodisperse Fe2O3 Supraparticles: Eco‐Friendly Fabrication, Gallic Acid Modification, Size‐Dependent Photothermal Conversion Efficiency, and Cellular Uptake

Contact Info

Product

Resources

About

Coordinatively Unsaturated Fe³⁺ Based Activatable Probes for Enhanced MRI and Therapy of Tumors

Facile synthesis of amino‐functionalized polyphosphazene microspheres and their application for highly sensitive fluorescence detection of Fe³⁺

Monodisperse Fe₂O₃ Supraparticles: Eco‐Friendly Fabrication, Gallic Acid Modification, Size‐Dependent Photothermal Conversion Efficiency, and Cellular Uptake