Coordination-responsive drug release inside gold nanorod@metal-organic framework core–shell nanostructures for near-infrared-induced synergistic chemo-photothermal therapy

Abstract

Multifunctional core-shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single gold nanorod (AuNR) core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core-shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.

Encapsulation of Plasmid DNA by Nanoscale Metal–Organic Frameworks for Efficient Gene Transportation and Expression

“…Herein, we aim to encapsulate large pDNA molecules, plasmid DNA expressing enhanced green fluorescent protein (pEGFP‐C1) (≈4700 bp, Scheme S1, Supporting Information), within the MOF and MOF‐polymer vectors via the rapid and economical one‐pot method to investigate their intracellular gene delivery and expression. Due to the low‐toxicity metal ions and imidazole linkers of the zeolitic imidazolate framework (ZIF) family of MOF, it is frequently employed as advanced functional nanocarriers for theranostics . As shown in Scheme , we have developed an one‐pot method to embed pEGFP‐C1 into ZIF‐8 nanostructures via the biomimetic mineralization (pEGFP‐C1@ZIF‐8).…”

Versatile bimetallic lanthanide metal-organic frameworks for tunable emission and efficient fluorescence sensing

“…As compared with other detection approaches, fluorescent sensors possess many advantages, such as high sensitivity, good reliability, and real-time detection [13][14][15][16][17] . While some fluorescent metal-organic frameworks (MOFs) showed a promising potential in probing metal ions [18][19][20][21][22] , MOF-based fluorescent platforms for effective and easy detection of different metal ions in aqueous solution have not been well investigated so far.…”

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

“…Furthermore, metal–organic particles based on metal–organic framework (MOF) or metal‐phenolates networks (MPNs) are also relatively new nanomaterials to consider for stimuli responsive effects. To date, MOFs are more used as drug reservoirs coated around responsive cores to achieve drug delivery and phototherapy for cancer therapy …”