Coordination Nanoparticles Formed by Fluorescent 2-Aminopurine and Au3+: Stability and Nanozyme Activities

Lopez, Anand; Liu, Juewen

doi:10.1007/s41664-019-00112-0

Cited by 7 publications

(4 citation statements)

References 44 publications

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“…39 The TMB only with Au@ PNIPAm or H 2 O 2 systems (red and blue lines) also exhibited a slight absorption band at 652 nm, which may be caused by the self-oxidation of TMB exposed within the air and light. 40 In addition, the catalytic efficiency of the Au@PNIPAm was compared with the same concentration of AuNPs (Figure 4c,d). Through the UV test, it could be found that the effect on the catalytic activity was relatively slight before and after the polymer coating on the AuNPs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…It was demonstrated that Au@PNIPAm could promote the oxidation of TMB to generate a blue product of oxidized TMB (Ox-TMB) which had an absorption peak at 655 nm . The TMB only with Au@PNIPAm or H 2 O 2 systems (red and blue lines) also exhibited a slight absorption band at 652 nm, which may be caused by the self-oxidation of TMB exposed within the air and light . In addition, the catalytic efficiency of the Au@PNIPAm was compared with the same concentration of AuNPs (Figure c,d).…”

Section: Resultsmentioning

confidence: 99%

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Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H₂O₂ Modulation

Sun

et al. 2022

Langmuir

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As a nanozyme, gold nanoparticles have some advantages compared with natural enzymes, such as stable structure, adjustable catalytic activity, multifunctionality, and recyclability. Due to their special dimension, they are easy to aggregate rapidly and lose their catalytic performance when exposed to normal saline or special pH environment. To avoid such a situation, Au@PNIPAm nanozymes with core−shell structure are constructed and their mimic peroxidase and glucose oxidase enzymatic activities are investigated. Kinetic examinations manifest that Au@PNIPAm nanozymes exhibited a high affinity for 3,3,5,5tetramethylbenzidine (TMB), hydrogen peroxide (H 2 O 2 ), and glucose. These predominant peroxidase-like and glucose-like oxidase Au@PNIPAm catalytic activities are successfully used in the detection of H 2 O 2 or glucose (LOD is 2.43 mM or 5.07 mM). Otherwise, the potential Au@PNIPAm nanozymes are provided with a clear ability for decomposing the intracellular H 2 O 2 in living cells. And it could protect cells from oxidative stress damage with inducing by H 2 O 2 . Therefore, it is easy to consider that Au@PNIPAm nanozymes show a certain possibility to retard cell senescence and increase the production of the hydroxyl radical which could prevent carcinogenesis of the cell.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H₂O₂ Modulation

Sun

et al. 2022

Langmuir

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“…Au 3+ ions can strongly coordinate to various nucleobases and thus affect the property of DNA. [43][44][45] Herein, we studied the interaction of HAuCl 4 with DNA by comparing four ways of mixing and incubation. 1) AuNSs were first mixed with a DNA (A30, T30, or C30) and then NH 2 OH and HAuCl 4 were added sequentially.…”

Section: Interaction Of Haucl 4 and Dnamentioning

confidence: 99%

“…Some nitrogen atoms in adenine such as N1 and N7 are known to be strong ligand for soft metals, such as gold, silver, and platinum. [43][44][45] The longer the DNA/HAuCl 4 incubation time, the lower the fluorescence recovery after adding KCN (Figure 3G; and Figure S3, Supporting Information). When the HAuCl 4 /DNA incubation time was 2 min, 80-90% of fluorescence recovery was observed.…”

Section: Reversible and Irreversible Au 3+ /Dna Interactionsmentioning

confidence: 99%

Reversible and Irreversible HAuCl₄ Binding to DNA for Seeded Gold Nanoparticle Growth and Opposite DNA and Aptamers Colorimetric Sensing Outcomes

Zandieh

Zheng

et al. 2022

Part & Part Syst Charact

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DNA‐directed seeded growth of gold nanoparticles has been used for the development of aptamer‐based biosensors with the assumption that target analytes can modulate the adsorption of aptamers to the gold seeds and thus affect the growth reaction. To understand the reaction, the effect of single‐ and double‐stranded DNA is first examined, and it is found that they have a similar promotion effect of anisotropic growth, suggesting that DNA cannot be detected using this method. By studying the interaction between HAuCl4 and DNA, both weak reversible binding and strong irreversible binding are identified, with the latter becoming dominating with a longer incubation time. Single‐ and double‐stranded DNA have similar weak binding to HAuCl4, and this weak binding is more important for the growth reaction. Then three aptamers are tested, where only cortisol appeared to modulate its aptamer adsorption and the growth reaction reflected aptamer binding. Hg2+ shows no advantage for its aptamer, and quinine induced aggregation of AuNPs cannot be detected by this reaction either. Therefore, each aptamer target needs to be individually studied to test if this method is applicable. It is also noted that DNA and aptamers have opposite outcomes for the target‐dependent growth reactions.

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Nucleobase, nucleoside, nucleotide, and oligonucleotide coordinated metal ions for sensing and biomedicine applications

2021

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Coordination Nanoparticles Formed by Fluorescent 2-Aminopurine and Au3+: Stability and Nanozyme Activities

Cited by 7 publications

References 44 publications

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H₂O₂ Modulation

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H₂O₂ Modulation

Reversible and Irreversible HAuCl₄ Binding to DNA for Seeded Gold Nanoparticle Growth and Opposite DNA and Aptamers Colorimetric Sensing Outcomes

Nucleobase, nucleoside, nucleotide, and oligonucleotide coordinated metal ions for sensing and biomedicine applications

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Coordination Nanoparticles Formed by Fluorescent 2-Aminopurine and Au3+: Stability and Nanozyme Activities

Cited by 7 publications

References 44 publications

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H2O2 Modulation

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H2O2 Modulation

Reversible and Irreversible HAuCl4 Binding to DNA for Seeded Gold Nanoparticle Growth and Opposite DNA and Aptamers Colorimetric Sensing Outcomes

Nucleobase, nucleoside, nucleotide, and oligonucleotide coordinated metal ions for sensing and biomedicine applications

Contact Info

Product

Resources

About

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H₂O₂ Modulation

Dual-Active Au@PNIPAm Nanozymes for Glucose Detection and Intracellular H₂O₂ Modulation

Reversible and Irreversible HAuCl₄ Binding to DNA for Seeded Gold Nanoparticle Growth and Opposite DNA and Aptamers Colorimetric Sensing Outcomes