Coordination-Driven Self-Assembly of Metal Ion–Antisense Oligonucleotide Nanohybrids for Chronic Bacterial Infection Therapy
Anqi Li,
Yan Zhang,
Li Wan
et al.
Abstract:Bacterial infection poses a significant challenge to wound healing and skin regeneration, leading to substantial economic burdens on patients and society. Therefore, it is crucial to promptly explore and develop effective methodologies for bacterial infections. Herein, we propose a novel approach for synthesizing nanostructures based on antisense oligonucleotides (ASOs) through the coordination-driven self-assembly of Zn 2+ with ASO molecules. This approach aims to provide effective synergistic therapy for chr… Show more
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