Coordination-driven assembly of proteins and nucleic acids in a single architecture for carrier-free intracellular co-delivery

Wang, Congli; Di, Zhenghan; Xiang, Zhichu; Zhao, Jian; Li, Lele

doi:10.1016/j.nantod.2021.101140

Cited by 32 publications

(17 citation statements)

References 46 publications

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“…[44,45] This coordination self-assembly utilized metal ion-linker coordination to obtain well-defined size and geometry for drug delivery systems with a single-step reaction under mild conditions. [46,47] This exceptional concept endows drug delivery systems with some advanced functionalities, such as structural diversity, enhanced stability and biocompatibility. [48,49] Particularly, metal-organic frameworks (MOFs), integrated by coordination of metal ions and organic linkers, have emerged as exciting carriers for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Liang

Wang

2021

ChemBioChem

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To overcome high toxicity, low bioavailability and poor water solubility of chemotherapeutics, a variety of drug carriers have been designed. However, most carriers are severely limited by low drug loading capacity and adverse side effects. Here, a new type of metal-drug nanoparticles (MDNs) was designed and synthesized. The MDNs self-assembled with Fe(III) ions and drug molecules through coordination, resulting in nanoparticles with high drug loading. To assist systemic delivery and prolong circulation time, the obtained MDNs were camouflaged with red blood cell (RBCs) membranes

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Section: Introductionmentioning

confidence: 99%

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Liang

Wang

2021

ChemBioChem

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“…1 a). Notably, magnesium cations (Mg 2+ )—a stimulator of the adaptive immune system—were added to the hydrogel to enhance the immunomodulatory activity of the hydrogel [ 41 , 42 ]. The as-prepared α-PDL1/PEIGel was semitransparent and estimated to contain 85% water mass ( Fig.…”

Section: Resultsmentioning

confidence: 99%

PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy

Xiao

Wang

et al. 2022

Materials Today Bio

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“…By introducing phosphotungstate and cysteine, CDT effects were ensured at both neutral and acidic pH, thus circumventing the limited CDT effect in neutral pH. [ 46 ] Other studies on Fe‐coordinated supramolecular nanoconstructs can be divided into two categories: Fe‐coordinated natural products [ 45 , 52 , 53 , 54 , 56 , 58 , 127 ] and nanoscale polymer systems. [ 47 , 55 , 57 , 128 ] All these works demonstrated the advantages and immense potential of Fe 2+/3+ coordination in constructing multifunctional supramolecular nanodrugs for cancer theranostic applications.…”

Section: Metal‐coordinated Supramolecular Self‐assemblies For Cancer Theranosticsmentioning

confidence: 99%

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

Wang

Jin

et al. 2021

Advanced Science

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Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal‐coordinated supramolecular self‐assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal‐coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME‐responsive nanomedicines. More importantly, TME‐responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal‐coordinated self‐assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal‐coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal‐coordinated supramolecular self‐assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME‐responsive nanomedicines for in vivo coordinated self‐assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.

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Coordination-driven assembly of proteins and nucleic acids in a single architecture for carrier-free intracellular co-delivery

Cited by 32 publications

References 46 publications

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

Red‐Blood‐Cell‐Membrane‐Coated Metal‐Drug Nanoparticles for Enhanced Chemotherapy

PEIGel: A biocompatible and injectable scaffold with innate immune adjuvanticity for synergized local immunotherapy

Metal‐Coordinated Supramolecular Self‐Assemblies for Cancer Theranostics

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