Coordination chemistry of some biologically active ligands

An efficient protocol for accessing β-amino dicarbonyl compounds through aza-Michael reaction

“…General synthesis of the polydentate ligands (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Reagents and conditions: a) piperidine, HOAc, EtOH, reflux, 12 h; b) secondary amine, water, r.t., catalyst.…”

“…One important result of this study was a straightforward synthesis of ten novel 2-(aryl-disubstituted amino-1-ylmethyl)-malonic acid diethyl esters (6)(7)(8)(9)(10)(11)(12)(13)(14)(15), which constitute a functionalized class of polydentate ligands. Despite prolonged reaction times, this aza-Michael protocol led to higher yields in an aqueous medium at room temperature, and consequently, would appear to be a simple and useful synthetic protocol.…”

“…6 This explanation clearly demonstrates that polydentate ligands are of special interest in the field of bioorganometallic chemistry. 7 In view of our interest in designing novel bimetallic coordinating ligands 8 endowed with potential action to inhibit the HI enzyme, the object of this study is the synthesis of polydentate ligands with the same topology, as drawn in Figure 1. 9 For preparation of such polydentate ligands, the aza-Michael reactions appear to be the key-step leading the expected b-amino esters adducts.…”

Synthesis and Characterization of Palladium(II) Complexes with 2-(2'-hydroxylphenyl)benzoxazole, 2-(2'-hydroxyl phenyl)benzothiazole or the Mixed Ligands

“…biological importance they are strongly coordinating agents and form stable complexes with various transition metal ions 17 . The biological activity of these ligands increase on complex formation with metal ions 18,19 .…”

New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions: Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium

“…In order to get a better insight in how the organotin species behave inside the biological systems, it is necessary to study their coordination behavior with biomolecules that can occur in the biological medium. Therefore, considerable efforts have been made to understand the binding mode of organotin compounds with biologically relevant ligands such as amino acids [1,2,[7][8][9][10][11][12][13] and dipeptides [1,2,[12][13][14][15][16][17][18][19][20][21][22][23][24], which constitute a very important class of biomolecules. Further, diorganotin(IV) derivatives of dipeptides [12,14,18] have been found to exhibit potent anti-inflammatory activity; thus such compounds may hold the potential to be placed in the class of nonsteroidal anti-inflammatory drugs (NSAIDs).…”