Coordination Chemistry of Nitrosyls and Its Biochemical Implications

Lewandowska, Hanna

doi:10.1007/430_2013_102

Cited by 14 publications

(9 citation statements)

References 377 publications

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“…Despite the biocompatibility and safety, an ideal iron delivery product should be available for iron storing cells for time necessary for its utilization. Fractionation of DNICLDL-treated blood revealed that despite very strong signal from DNIC was *Ca 21 and Zn 21 are also bound, but less preferably at low pH values.…”

Section: Discussionmentioning

confidence: 98%

“…The most recognized moieties of iron‐nitrosyl group coordination in proteins are sulfhydryl groups of cysteines . These soft Lewis bases have an excellent affinity to the Fe(NO) group . Indeed, ApoB100 with its 24 cysteines is the richest in thiols among lipoprotein constituents (see Supporting Information Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it appeared interesting to find out, if the lipoprotein is able to undergo the process of iron‐nitrosylation, commonly observed for other proteins and what is the biological fate of the DNIC‐modified LDL particles. DNICs with proteins are well known as biological transducers of NO . Indeed, DNIC‐modification of a protein introduces two important biological agents: NO and Fe.…”

Section: Introductionmentioning

confidence: 99%

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LDL dinitrosyl iron complex: A new transferrin‐independent route for iron delivery in hepatocytes

et al. 2018

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In view of the interrelations between NO, Fe, and LDL in the cardiovascular system it appears interesting to find out, if the lipoprotein particles undergo the process of iron-nitrosylation, commonly observed for other proteins and what is the biological fate of iron-nitrosylated LDL particles. Iron-nitrosylated LDL preparation containing Fe(NO) motif (DNICLDL) was obtained and characterized for the first time. In order to test its interactions with potential target cells, DNICLDL was administered to the hepatoma HepG2 cells. The effects were referred to those induced by native LDL (nLDL) and oxidized LDL (oxLDL) particles. DNICLDL administration considerably increased total iron content in the studied cell line, but did not influence the level of calcein-chelatable ions. DNICLDL was found to be low toxic to cells. The study suggests that DNICLDL might be a potential transducer of iron. © 2017 BioFactors, 44(2):192-201, 2018.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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LDL dinitrosyl iron complex: A new transferrin‐independent route for iron delivery in hepatocytes

et al. 2018

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“…DNICs possess two NO groups and two thiolate ligands; the former can be thiol groups of proteins (protein-bound, or high molecular weight DNICs) or free thiols (low molecular weight DNICs). DNICs, together with S -nitrosothiols, are thought to be storage and transport forms of NO [ 8 , 9 , 10 ]. At the same time, DNICs are NO donors that decompose through non-enzymatic mechanism.…”

Section: Introductionmentioning

confidence: 99%

NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells

et al. 2017

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We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM exposure. The high susceptibility of A172 cells to ETM was attributed to its NO-donor properties since no toxicity was detected for the N-ethylthiourea ligand.

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“…Alternatively, nitrosylated iron can coordinate imidazole rings present in residues such as histidine or purines. 16 The formation of high and low molecular-weight DNICs with thiol ligands has been observed in many kinds of organisms and under a wide range of physiological conditions associated with inflammation, Parkinson's disease or cancer.…”

Section: Introductionmentioning

confidence: 99%

Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity

et al. 2015

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Dinitrosyl iron(i) complexes (DNICs), intracellular NO donors, are important factors in nitric oxide-dependent regulation of cellular metabolism and signal transduction. It has been shown that NO diminishes the toxicity of iron ions and vice versa. To gain insight into the possible role of DNIC in this phenomenon, we examined the effect of GS-DNIC formation on the ability of iron ions to mediate DNA damage, by treatment of the pUC19 plasmid with physiologically relevant concentrations of GS-DNIC. It was shown that GS-DNIC formation protects against the genotoxic effect of iron ions alone and iron ions in the presence of a naturally abundant antioxidant, GSH. This sheds new light on the iron-related protective effect of NO under the circumstances of oxidative stress.

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Coordination Chemistry of Nitrosyls and Its Biochemical Implications

Cited by 14 publications

References 377 publications

LDL dinitrosyl iron complex: A new transferrin‐independent route for iron delivery in hepatocytes

LDL dinitrosyl iron complex: A new transferrin‐independent route for iron delivery in hepatocytes

NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells

Formation of glutathionyl dinitrosyl iron complexes protects against iron genotoxicity

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