Coordination Centres of Purine Nucleotides: Adenosine‐5′‐diphosphate and Adenosine‐5′‐triphosphate in their Reactions with Nickel(II), Cobalt(II) and Tetramines

Abstract

Interactions between the nucleotides: adenosine-5Ј-diphosphate (ADP) and adenosine-5Ј-triphosphate (ATP) with Ni II and Co II ions, as well as with spermine (Spm) and 1,11-diamine-4,8-diazaundecane (3,3,3-tet) are the subject of this study. Composition and stability constants of mixed complexes thus formed have been determined on the basis of the potentiometric measurements, whereas interaction centres in ligands have been identified by VIS and NMR spectral parameter analysis. Mixed tetraprotonated complexes with Ni II , i.e. Ni(ADP)H 4 (Spm), Ni(ATP)H 4 (Spm), Ni(ADP)H 4 (3,3,3-tet) and Ni(ATP)H 4 (333-tet), are identified as ML·······LЈ type adducts, in which the main coordination centre is the nucleotide nitrogen N(1) or N(7) donor atom, and the fully protonated polyamine is engaged in noncovalent interactions with nucleotide phosphate group oxygen atoms. Ni(ADP)H 2 (Spm), 2281 Ni(ATP)H 2 (Spm), Ni(ADP)H 2 (3,3,3-tet) and Ni(ATP)H 2 (3,3,3-tet) complexes represent the {N3} coordination type In diprotonated mixed complexes of Ni II with spermine are weak noncovalent interligand interactions, providing an additional stabilising effect. Formation of ML·······LЈ type molecular complexes has been observed in systems with Co II : Co(ADP)H 4 (Spm), Co(ATP)H 4 (Spm), Co(ADP)H 4 (3,3,3-tet) and Co(ATP)H 4 (3,3,3-tet), in which the N(7) atom and oxygen atoms of the phosphate group are involved in coordination and the fully protonated polyamine is engaged in noncovalent interactions with the nucleotide N(1).

Direct Detection of the Labile Nickel Pool in Escherichia coli: New Perspectives on Labile Metal Pools

“…Other minor complexes may contribute to the LNiP, and the distribution may change with metabolic conditions. Displayed structures are based on known structures of related complexes; − W represents water. The Ni 2+ (GSSG) structure was optimized using DFT and visualized using GaussView.…”