2000
DOI: 10.1523/jneurosci.20-17-06570.2000
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Coordinated Transitions in Neurotransmitter Systems for the Initiation and Propagation of Spontaneous Retinal Waves

Abstract: Spontaneous waves of excitation in the developing mammalian retina are mediated, to a large extent, by neurotransmission. However, it is unclear how the underlying neurotransmitter systems interact with each other to play specific roles in the formation of retinal waves at various developmental stages. In particular, it is puzzling why the waves maintain a similar propagation pattern even after underlying neurotransmitter systems have undergone drastic developmental changes. Using Ca 2ϩ imaging and patch clamp… Show more

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Cited by 100 publications
(147 citation statements)
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“…To explore how synaptic networks in wt retina adjust to acute nicotinic receptor blockade, we applied DH␤E to wt retinas in vitro (n ϭ 6 retinas) for several hours and recorded their spiking activity. As in previous studies (Feller et al, 1996;Wong et al, 1998Wong et al, , 2000Bansal et al, 2000;Sernagor et al, 2000;Zhou and Zhao, 2000), synchronous bursting activity was abolished and most recording sites were silent within minutes of DH␤E application (Fig. 6 A).…”
Section: Spontaneous Activity Recovers During Long-term Blockade In Wsupporting
confidence: 85%
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“…To explore how synaptic networks in wt retina adjust to acute nicotinic receptor blockade, we applied DH␤E to wt retinas in vitro (n ϭ 6 retinas) for several hours and recorded their spiking activity. As in previous studies (Feller et al, 1996;Wong et al, 1998Wong et al, , 2000Bansal et al, 2000;Sernagor et al, 2000;Zhou and Zhao, 2000), synchronous bursting activity was abolished and most recording sites were silent within minutes of DH␤E application (Fig. 6 A).…”
Section: Spontaneous Activity Recovers During Long-term Blockade In Wsupporting
confidence: 85%
“…Retinal structure develops normally in the absence of local ACh release Functional cholinergic pathways are present in the developing retina even before synaptic circuits are established (Yamashita et al, 1994;Wong, 1995;Zhou and Zhao, 2000;Feller, 2002;Pearson et al, 2002). ACh has been implicated in regulating local and global changes in the structural maturation of the retina.…”
Section: Discussionmentioning
confidence: 99%
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“…This activity is initially mediated by cholinergic circuits and then by glutamatergic circuits (Wong, 1999;Zhou and Zhao, 1999;Bansal et al, 2000;Zhou and Zhao, 2000). Several experimental results indicate that waves mediated by cholinergic circuits require the activation of nAChRs.…”
Section: Nachr-mediated Retinal Wavesmentioning
confidence: 99%
“…Second, the periodic calcium increases, action potentials, and compound postsynaptic currents associated with waves can all be blocked by a variety of nAChRs antagonists [ Fig. 2(B)] (Feller et al, 1996;Penn et al, 1998;Sernagor and Grzywacz, 1999;Bansal et al, 2000;Zhou and Zhao, 2000). Third, simultaneous recordings from rabbit starburst amacrine cells and RGCs show that the cholinergic starburst cells that synapse onto RGCs undergo spontaneous depolarizations that are correlated with the depolarizations of neighboring RGCs (Zhou, 1998) These recordings also show that, like RGCs, starburst amacrine cells themselves are excited via synaptic input during waves.…”
Section: Nachr-mediated Retinal Wavesmentioning
confidence: 99%