Coordinated responses to developmental hormones in the Kenyon cells of the adult worker honey bee brain (Apis mellifera L.)

Velarde, Rodrigo; Robinson, Gene E.; Fahrbach, Susan E.

doi:10.1016/j.jinsphys.2008.10.006

Cited by 45 publications

(49 citation statements)

References 77 publications

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“…A subset of workers (responders) reared outside of the hive environment responds to consistent and intense QMP exposure with elevated ecdysteroid titers. These circulating ecdysteroids have the capacity to impact behavior and physiology through regulation of brain gene expression via brain ecdysteroid receptors (Velarde et al 2009;Fahrbach et al 2017), independent of reproductive function. This view is consistent with our finding that the traditional morphological signs of the early stages of ovarian activation cannot be used as predictors of ecdysteroid titers in worker honey bees.…”

Section: Discussionmentioning

confidence: 99%

“…The expression of ecdysteroid receptors (EcR) in adult worker brains and ovaries suggests that steroids of ovarian origin can potentially regulate adult behavior and physiology (Nemoto and Hara 2007;Takeuchi et al 2007;Velarde et al 2009;Mullen et al 2014;Fahrbach et al 2017), but the few studies that have measured hemolymph ecdysteroids in adult workers have reported variable but generally low titers (Robinson et al 1991;Hartfelder et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Queen mandibular pheromone modulates hemolymph ecdysteroid titers in adult Apis mellifera workers

Trawinski

Fahrbach

2018

Apidologie

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-To test the hypothesis that exposure to queen mandibular pheromone (QMP) modulates ecdysteroid production in adult worker honey bees, ecdysteroids were measured in hemolymph and other tissues of individual adult worker honey bees reared with or without QMP in cages and field colonies. Ecdysteroid titers were higher in caged workers exposed to QMP continuously from the first day of adult life than in workers reared without QMP. Statistical cluster analysis suggested the possibility that a subgroup of workers (Bresponders^) is more sensitive to QMP in this regard than other workers. In 12-day-old workers, ecdysteroid titers in workers reared in queenright (QR) colonies were similar to those observed in cages with QMP, but lower than those in queenless (QL) colonies. Differences in number of ovarioles or degree of ovarian activation did not correlate with hemolymph ecdysteroids. Previous studies have demonstrated ecdysteroids in hemolymph in very young adult workers and in workers in QL colonies; the present study indicates that production of ecdysteroids occurs in older adult worker honey bees in the absence of morphological signs of ovarian activation, with cage studies revealing a modulatory role for QMP masked in the complex environment of the hive.ecdysteroids / ovary / queen mandibular pheromone / queenless / queenright

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Queen mandibular pheromone modulates hemolymph ecdysteroid titers in adult Apis mellifera workers

Trawinski

Fahrbach

2018

Apidologie

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“…Despite a body of evidence suggesting that ecdysteroids may have lost their behavioral role in adults during the evolution of eusocial insect taxa (Hartfelder et al, 2002), there are examples of divergent ecdysteroid titers being associated with behavioral castes (Röseler et al, 1985;Bloch et al, 2000b;Brent et al, 2006), and there is emerging evidence of a link between ecdysteroids and foraging onset in worker honey bees (Velarde et al, 2009;Wang et al, 2010). Whether ecdysteroids impact the behavior of P. californicus workers remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…JH has been associated with division of labor among workers of the honey bee (reviewed by Robinson and Vargo, 1997), the bumble bee (Bloch et al, 2000a), the queenless ant Streblognathus peetersi (Brent et al, 2006) and Polistes wasps (Giray et al, 2005). Although no causal route from ecdysteroid content to division of labor has been demonstrated (Hartfelder et al, 2002), this group of hormones is suspected of having priming effects on honey bee worker behavior (Velarde et al, 2009;Wang et al, 2009;Amdam and Page, 2010), and has links to adult reproductive activity (Robinson et al, 1991). Ecdysteroids act via effects on the axis of brain/fat body/ovaries (Wang et al, 2010;Yamazaki et al, 2011), and ecdysteroid production is often linked to insect ovarian activation (Raikhel et al, 2005;Dong et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Worker division of labor and endocrine physiology are associated in the harvester ant,Pogonomyrmex californicus

Doležal

Brent

Hölldobler

et al. 2012

Journal of Experimental Biology

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SUMMARYIn Pogonomyrmex californicus harvester ants, an age-associated division of labor occurs in the worker caste, in which young workers perform in-nest tasks and older workers forage for food. Here, we tested whether this behavioral division is age based or age flexible, and whether it coincides with differential expression of systemic hormones with known roles in behavioral regulation. Whole-body content of juvenile hormone (JH) and ecdysteroids was determined in workers from (1) age-typical colonies, in which a typical age structure is maintained and workers transition across behaviors naturally, and (2) single-cohort colonies, which are entirely composed of same-aged workers, facilitating the establishment of age-independent division of labor. Foragers from both colony types had higher JH and lower ecdysteroid content than workers performing in-nest tasks, suggesting that age is not the sole determinant of worker behavior. This association between hormone content and behavior of P. californicus workers is similar to that previously observed in founding queens of this species. Because these hormones are key regulators of development and reproductive behavior, our data are consistent with the reproductive ground plan hypothesis (RGPH), which posits that the reproductive regulatory mechanisms of solitary ancestors were co-opted to regulate worker behavior.

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“…Ecdysone also plays a role in remodeling of the adult brain in the house cricket (Acheta domesticus), in this case by inhibiting neuroblast proliferation in the MBs and triggering their differentiation into interneurons (Cayre et al 2000). In honeybees (Apis mellifera L.), ecdysone exposure activates an EcR-mediated transcriptional cascade in the adult MB neurons, suggesting that ecdysone is important for reorganization of the adult brain (Velarde et al 2009). Moreover, we have recently discovered that long-term courtship memory in Drosophila, which is likely associated with the stable modification of synaptic function and/or structure in the adult brain, is dependent on EcR-mediated ecdysone signaling (Ishimoto et al 2009).…”

Section: /Ecrmentioning

confidence: 99%

The Steroid Molting Hormone Ecdysone Regulates Sleep in Adult Drosophila melanogaster

Ishimoto

Kitamoto

2010

Genetics

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Ecdysone is the major steroid hormone in insects and plays essential roles in coordinating developmental transitions such as larval molting and metamorphosis through its active metabolite 20-hydroxyecdysone (20E). Although ecdysone is present throughout life in both males and females, its functions in adult physiology remain largely unknown. In this study we demonstrate that ecdysonemediated signaling in the adult is intimately involved in transitions between the physiological states of sleep and wakefulness. First, administering 20E to adult Drosophila melanogaster promoted sleep in a dosedependent manner, and it did so primarily by altering the length of sleep and wake bouts without affecting waking activity. Second, mutants for ecdysone synthesis displayed the ''short-sleep phenotype,'' and this was alleviated by administering 20E at the adult stage. Third, mutants for nuclear ecdysone receptors showed reduced sleep, and conditional overexpression of wild-type ecdysone receptors in the adult mushroom bodies resulted in an isoform-specific increase in sleep. Finally, endogenous ecdysone levels increased after sleep deprivation, and mutants defective for ecdysone signaling displayed little sleep rebound, suggesting that ecdysone is involved in homeostatic sleep regulation. In light of the recent finding that lethargus-a period at larval-stage transitions in the nematode worm Caenorhabditis elegans-is a sleep-like state, our results suggest that sleep is functionally and mechanistically linked to a genetically programmed, quiescent behavioral state during development.

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Coordinated responses to developmental hormones in the Kenyon cells of the adult worker honey bee brain (Apis mellifera L.)

Cited by 45 publications

References 77 publications

Queen mandibular pheromone modulates hemolymph ecdysteroid titers in adult Apis mellifera workers

Queen mandibular pheromone modulates hemolymph ecdysteroid titers in adult Apis mellifera workers

Worker division of labor and endocrine physiology are associated in the harvester ant,Pogonomyrmex californicus

The Steroid Molting Hormone Ecdysone Regulates Sleep in Adult Drosophila melanogaster

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