Coordinated movement of eukaryotic translation initiation factors 1, 1A, and 5 within the 43S ribosomal preinitiation complex (PIC) mediates the response to start codon recognition.
Abstract:Eukaryotic translation initiation factor (eIF) 5 acts as a GTPase activating protein for eIF2 that carries the first tRNA onto the ribosome. Recent data have shown that eIF5 antagonizes eIF1, enhancing its release from the PIC in response to start codon recognition. eIF1 release promotes the conversion of the PIC from open conformation that scan the mRNA to closed one arrested on the start codon. Recent data indicate that an interaction occurs between eIF1A and eIF5 upon start codon recognition by PIC. We obse… Show more
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