Cooperative NHC and Photoredox Catalyzed Radical Aminoacylation of Alkenes to Tetrahydropyridazines
Wen‐Deng Liu,
Jiyuan Gao,
Jia‐Nan Mo
et al.
Abstract:Tetrahydropyridazines constitute an important structural motif found in numerous natural products and pharmaceutical compounds. Herein, we report an aminoacylation reaction of alkenes that enables the synthesis of 1,4,5,6‐tetrahydropyridazines through cooperative N‐heterocyclic carbene (NHC) and photoredox catalysis. This approach involves the 6‐endo‐trig cyclization of N‐centered hydrazonyl radicals, generated via single‐electron oxidation of hydrazones, followed by a radical–radical coupling step. The mild p… Show more
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