Cooperative mechanisms underlie differences in myocardial contractile dynamics between large and small mammals
Jitandrakumar R. Patel,
Kayla J.V. Park,
Aidan S. Bradshaw
et al.
Abstract:Ca2+ binding to troponin C (TnC) and myosin cross-bridge binding to actin act in a synergistic cooperative manner to modulate myocardial contraction and relaxation. The responsiveness of the myocardial thin filament to the activating effects of Ca2+ and myosin cross-bridge binding has been well-characterized in small mammals (e.g., mice). Given the nearly 10-fold difference in resting heart rates and twitch kinetics between small and large mammals, it is unlikely that the cooperative mechanisms underlying thin… Show more
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