Abstract:Organocatalysis is nowadays recognized as the third pillar of asymmetric synthesis, standing next to metal catalysis and enzymatic transformations. Proline has shown up as an ideal organocatalyst, being inexpensive and readily available. However, this amino acid has also manifested its limitations. Compared to the chemical modification of proline, the approach through adding small hydrogen-bond-donating cocatalysts to interact with proline is particularly attractive. Various additives have been investigated to… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.