Cooperative Gating of a K+ Channel by Unmodified Biological Anionic Lipids Viewed by Solid-State NMR Spectroscopy
Maryam Yekefallah,
Evan J. van Aalst,
Roy A. M. van Beekveld
et al.
Abstract:Lipids adhere to
membrane proteins to stimulate or suppress molecular
and ionic transport and signal transduction. Yet, the molecular details
of lipid–protein interaction and their functional impact are
poorly characterized. Here we combine NMR, coarse-grained molecular
dynamics (CGMD), and functional assays to reveal classic cooperativity
in the binding and subsequent activation of a bacterial inward rectifier
potassium (Kir) channel by phosphatidylglycerol (PG), a common component
of many membranes. Past stu… Show more
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