Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial

Wu, Jian; Oka, Jun; Higuchi, Mitsuru; Tabata, Izumi; Toda, Toshiya; Fujioka, Maiko; Fuku, Noriyuki; Teramoto, Takanori; Okuhira, Takenori; Ueno, Tomomi; Uchiyama, Shigeto; Urata, Kouji; Yamada, Kazuhiko; Ishimi, Yoshiko

doi:10.1016/j.metabol.2005.10.002

Cited by 106 publications

(118 citation statements)

References 43 publications

(51 reference statements)

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“…However, a recent metaanalysis suggested women may need to be equol producers to gain bone sparing benefit from isoflavone consumption [72]. Wu et al studied the effect of supplementing 75 mg of isoflavones on BMD in one hundred and twenty-eight postmenopausal Japanese women over 24 weeks, demonstrating a significant improvement to BMD (per cent change) following isoflavone consumption in equol producers versus non-equol producers [73,74]. Similarly, Frankenfeld et al achieved a 20% reduction in spinal BMD in equol producers following a 3-day soy challenge in ninety-two postmenopausal women, when comparing nonequol producers and producers.…”

Section: Osteoporosismentioning

confidence: 99%

Does equol production determine soy endocrine effects?

et al. 2012

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Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, 30-50% of individuals metabolize daidzein into equol and are known as equol producers. Equol production may be the source of benefit from isoflavones in endocrine disease.

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Section: Osteoporosismentioning

confidence: 99%

Does equol production determine soy endocrine effects?

et al. 2012

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“…Previous animal studies have shown that genistein treatment increased bone mineral density (BMD) and improved bone biomechanical performance in ovariectomized (OVX) rodents [12,13] . Clinical studies have also demonstrated that phytoestrogen can effectively increase the BMD of vertebrae and hip bones in postmenopausal women without side effects, which suggested that genistein plays an important role in the regulation of bone formation and bone resorption [14][15][16][17] . phosDose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone www.chinaphar.com Li YQ et al Acta Pharmacologica Sinica npg phatase (ALP) and osteocalcin (OC) are widely used markers for bone formation.…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone

Xing

Wang

et al. 2011

Acta Pharmacol Sin

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Aim: To investigate the effect of genistein on bone homeostasis in mandibular subchondral bone of rats. Methods: Female SD rats were administered with genistein (10 and 50 mg/kg) or placebo by oral gavage for 6 weeks. Then the animals were sacrificed, and histomorphology and micro-structure of mandibular condyle were examined using HE staining and micro-CT analysis, respectively. The expression levels of alkaline phosphatase (ALP), osteocalcin (OC), osteoprotegerin (OPG), the receptor activator of nuclear factor κB ligand (RANKL) and estrogen receptors (ERs) in mandibular condyle were detected using real-time PCR. Cultured osteoblasts were prepared from rat mandibular condyle for in in vitro study. The cells were treated with genistein (10 -7 or 10 -4 mol/L) for 48 h. The expression of the bone homeostasis-associated factors and estrogen receptors (ERs) was detected using realtime PCR, and ER silencing was performed. Results: At both the low-and high-doses, genistein significantly increased the bone mineral density (BMD) and bone volume, and resulted in thicker subchondral trabecular bone in vivo. In both in vivo and in vitro study, the low-dose genistein significantly increased the expression of ALP, OC and OPG, but decreased the expression of RANKL and the RANKL/OPG ratio. The high-dose genistein decreased the expression of all these bone homeostasis-associated factors. Both the low and high doses of genistein significantly increased the expression of ERβ, while ERα expression was increased by the low dose genistein and decreased by the high dose genistein. ERβ silencing abrogated most of the effects of genistein treatment. Conclusion: In rat mandibular condylar subchondral bone, low-dose genistein increases bone formation and inhibit bone resorption, while excess genistein inhibits both bone formation and resorption. The effects of genistein were predominantly mediated through ERβ.

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“…Wu et al also performed one more study to evaluate effects of isoflavone intake and walking and their interaction on serum lipid metabolism in postmenopausal women over 24 weeks [16]. One hundred twenty-eight subjects were randomly assigned to four groups: placebo; placebo combined with walking (3 times/week); isoflavone intake (75 mg of isoflavones conjugates/day); and isoflavone combined with walking.…”

Section: Wu Et Al [15]mentioning

confidence: 99%

Effects of Soy Protein and Isoflavones Intake on HDL Metabolism in Asian Populations

Yanai

2014

J Endocrinol Metab

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High-density lipoprotein (HDL) has been shown to have a variety of functions that contribute to anti-atherogenesis. Therefore, low HDL-cholesterol (HDL-C) level is significantly associated with the development of coronary artery diseases (CADs). Soy and isoflavones have been proposed to reduce the risk of CAD. However, the underlying mechanisms for soy and isoflavone-induced reduction of coronary risks remain largely unknown. To understand effects of lifestyle on lipids metabolism, the existence of interracial differences should be considered. Here we reviewed published articles about effects of soy and isoflavone intake on HDL metabolism. We regarded systematic review and meta-analysis and also clinical studies which were performed in Asian populations as important articles in this review. Evidences obtained from clinical trials performed in Asian populations showed that effects of soy protein and isoflavones on HDL-C were limited, which may be due to limited studied population such as postmenopausal women. Meta-analyses indicated that intake of soy protein and isoflavones is beneficially associated with HDL metabolism.

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Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial

Cited by 106 publications

References 43 publications

Does equol production determine soy endocrine effects?

Does equol production determine soy endocrine effects?

Dose-dependent effects of genistein on bone homeostasis in rats' mandibular subchondral bone

Effects of Soy Protein and Isoflavones Intake on HDL Metabolism in Asian Populations

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