Cooperative Catalysis With Block Copolymer Micelles: A Combinatorial Approach

Abstract

A rapid approach to identifying complementary catalytic groups using combinations of functional polymers is presented. Amphiphilic polymers with "clickable" hydrophobic blocks were used to create a library of functional polymers, each bearing a single functionality. The polymers were combined in water, yielding mixed micelles. As the functional groups were colocalized in the hydrophobic microphase, they could act cooperatively, giving rise to new modes of catalysis. The multipolymer "clumps" were screened for catalytic activity, both in the presence and absence of metal ions. A number of catalyst candidates were identified across a wide range of model reaction types. One of the catalytic systems discovered was used to perform a number of preparative-scale syntheses. Our approach provides easy access to a range of enzyme-inspired cooperative catalysts.

Dynamic lipid aptamers: non-polymeric chemical path to early life

“…Another study depicts micelles composed of different binary combinations of lipids that catalyze a plethora of synthetic reactions to various degrees. 29 A wide range of such lipidmediated reactions as reviewed 30 suggests that lipids may reveal a spectrum of enzyme-like catalytic capacities, acting as reaction promoters and regulators. 24…”

“…33 Bottom, enhanced synthesis of a new lipid by joining an externally supplied headgroup to an apolar tailgroup residing within the micellar core, as experimentally described, 30,36 proposed to happen via cooperative interactions with several lipids, as alluded based on experiments. [27][28][29] (c) A schematic view of the Lipid-First scenario for life's origin. A lipid micellar assembly is spontaneously formed from environmental molecules.…”

One-Pot Parallel Synthesis of Unclosed Cryptands—Searching for Selective Anion Receptors via Static Combinatorial Chemistry Techniques

“…It is usually used to search for new drugs in the pharmaceutical industry, 1 although it is increasingly being used in creating new semiconductors, 2 catalysts, 3 and polymers. 4 Parallel synthesis and analysis of the resulting library allow costs to be minimized and significantly shorten the time of studies. Subsequently, potentially useful compounds are synthesized and analyzed by classical methods, which allow compounds that exhibit false positive properties to be eliminated, for example, as components showing synergic effects.…”

Fluorophoric Conjugate of N-Alkyl Naphthalimide in Sodium Dodecyl Sulfate As a Tunable and Sustainable Sensing System: Differential Sensing of Zn2+ and Al3+ and the Application of Its Zn2+ Complex in Detecting Dipicolinic Acid, a Component of Anthrax Bacterial Endospores

“…Along with the suitable surfactant at its specific concentration, one can easily incorporate water-insoluble fluorescent probes in the local hydrophobic environment. These surfactant media have been utilized for various applications, viz., drug delivery, − organic transformations, − and sensing of anions, cations, and bacterial species. − The present work is a successful attempt in this direction by transforming a hydrophobic and nonsensor fluorescent molecule into a water-soluble and selective sensor for Al 3+ and Zn 2+ by incorporating this into the sodium dodecyl sulfate (SDS) surfactant media. Further, the Zn 2+ hybrid of the SDS self-assembly has been explored for sensing a component of anthrax bacteria, i.e., dipicolinic acid (DPA).…”