Cooperative assistance of a sulfonamide in a proline-mediated direct asymmetric aldol addition

Abstract

A sulfonamide moiety was introduced at the C-4 position of proline, cis to the –COOH group, to examine a possible intramolecular synergistic interaction between the two functional groups and the...

Visible-Light-Induced Decarboxylative Aminosulfonylation of (Hetero)aryl Carboxylic Oxime Esters

“…So far, about 166 sulfonamide containing drugs have been approved by FDA, and a growing number of aryl sulfonamides have been developed as drug candidates with broad biological activities . Moreover, bifunctional sulfonamide reagents are wildly and successfully used in asymmetric organocatalysis as hydrogen-bonding catalysts due to their strong acidity and lesser self-aggregation property …”