Cooperative antiproliferative and differentiation-enhancing activity of medicinal plant extracts in acute myeloid leukemia cells

Zhamanbayeva, Gulzhan; Aralbayeva, Araylim N.; Murzakhmetova, M. K.; Tuleukhanov, Sultan; Danilenko, Michael

doi:10.1016/j.biopha.2016.04.062

Cited by 20 publications

(10 citation statements)

References 44 publications

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“…Antiproliferative effects of extracts from Rosa canina leaves were observed on myeloblastic leukaemia cell model (HL60 cells) and to a lesser extent on myelomonocytic leukaemia model (U937 cells), alone or combined with other plant extracts [88]. Incubation with plant extracts resulted in an upregulation of vitamin D receptor and retinoid X receptor, accompanied by an increase in the transcriptional activity of this receptor complex.…”

Section: Rose Hip and Diseasementioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

138

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Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.

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Section: Rose Hip and Diseasementioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

138

View full text Add to dashboard Cite

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“…Elsewhere, Zhamanbayeva et al ( 2016 ) studied the antiproliferative and differentiation-enhancing activity of various plant extracts (10–100 μg/ml), including water-ethanol extract from leaves of sea buckthorn: it was found to have a total polyphenol content of approximately 46 mg GA equivalent/g dried extract, total flavonoid content of approximately 23 mg quercetin equivalent/g dried extract. The authors observed that the tested extracts, including sea buckthorn extract, reduced the growth and viability of acute myeloid leukemia cells; in addition, at non-cytotoxic doses, they also potentiated cell differentiation induced by a low concentration of 1α,25-dihydroxyvitamin D 3 , in a manner dependent on cell type.…”

Section: Anticancer Activity Of Sea Buckthornmentioning

confidence: 99%

The Anticancer Activity of Sea Buckthorn [Elaeagnus rhamnoides (L.) A. Nelson]

2018

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Various parts of sea buckthorn [Elaeagnus rhamnoides (L.) A. Nelson], particularly the berries, known also as seaberries, or Siberian pineapples, are characterized by a unique composition of bioactive compounds: phenolic compounds, vitamins (especially vitamin C), unsaturated fatty acids, and phytosterols such as beta-sitosterol. These berries, together with the juices, jams, and oils made from them, have a range of beneficial antioxidant, anti-inflammatory, and anticancer effects. This short review discusses whether sea buckthorn may represent a “golden mean” for the treatment of cancers: It has anti-proliferation properties and can induce apoptosis and stimulate the immune system, and sea buckthorn oil counteracts many side effects of chemotherapy by restoring kidney and liver function, increasing appetite, and keeping patients in general good health. Although the anticancer activity of sea buckthorn has been confirmed by many in vitro and animal in vivo studies, the treatment and prophylactic doses for humans are unknown. Therefore, greater attention should be paid to the development of well-controlled and high-quality clinical experiments in this area.

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“…За последние годы значительно возрос интерес к поиску систем с антиканцерогенным, анти- мутагенным, антипролиферативным действием среди пищевых продуктов, пищевого сырья и пищевых полуфабрикатов. Так, среди наиболее интересных объектов можно выделить: по пищевым продуктам -вино [16], красные томаты [17]; по пищевому сырью -бобы [18], растительное сырье [19]; по пищевым полуфабрикатам -антоциановый комплекс из темной кислой вишни [20]. При этом в ряде исследований используется контроль биологической активности исследуемых объектов Так, например, это может быть доксорубицин [16], эллиптицин [17].…”

Section: Introductionunclassified

“…В других экспериментах применяется негативный контроль, например, для семян вигны [21]. Но в ряде работ внимание сосредоточено на сравнении нескольких пищевых объектов между собой, другие объекты не включаются, например, при исследовании фруктов и вина из черной смородины [22], растительного сырья (орегано, шиповник, семена крушины) [19].…”

Section: Introductionunclassified