Cooling for newborns with hypoxic ischaemic encephalopathy

Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low‐technology methods: a systematic review and meta‐analysis

“…The beneficial effect of LTTH described in our review is similar to that of TH using predominantly high‐technology methods, reported in the most recent Cochrane review . The Cochrane review showed comparable decreases in mortality [RR 0.75 (95% CI 0.64, 0.88), RD −0.09 (95% CI −0.13, −0.04)] and morbidity in survivors at 18–24 months [RR 0.77 (95% CI 0.63, 0.94), RD −0.13 (95% CI −0.19, −0.07)].…”

Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low‐technology methods: a systematic review and meta‐analysis

“…The beneficial effect of LTTH described in our review is similar to that of TH using predominantly high‐technology methods, reported in the most recent Cochrane review . The Cochrane review showed comparable decreases in mortality [RR 0.75 (95% CI 0.64, 0.88), RD −0.09 (95% CI −0.13, −0.04)] and morbidity in survivors at 18–24 months [RR 0.77 (95% CI 0.63, 0.94), RD −0.13 (95% CI −0.19, −0.07)].…”

Using a novel laminar flow unit provided effective total body hypothermia for neonatal hypoxic encephalopathy

“…The 26 infants were severely ill on admission and when they were enrolled to the study (Tables ). The severity of their conditions was similar to that described in other studies, with moderate or severe encephalopathy and intrapartum hypoxia–ischaemia with low Apgar scores, ongoing resuscitation, cord or arterial blood gas within one hour of birth with a pH of <7.1 and/or a base deficit in excess of 12 .…”

aEEG and neurologic exam findings correlate with hypoxic–ischemic brain damage severity in a piglet survival model

“…Our model demonstrated remarkable translational power. Despite the fact that our piglets were able to spontaneously breathe, eat and even walk, post-HI mortality in our experiment attained 25%, which was comparable to that described for similar models in piglets 10,12,18 but slightly superior to that reported for asphyxiated newborns with moderate encephalopathy 19 likely because in the experimental model piglets were not benefited from post-HI sustained critical care. In agreement, the HI insult led to a remarkable increase in brain cortex of cell death as well as Lac/NAA ratio-a well-known surrogate for HI brain damage in newborn animals and humans.…”

Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low‐technology methods: a systematic review and meta‐analysis

“…The beneficial effect of LTTH described in our review is similar to that of TH using predominantly high‐technology methods, reported in the most recent Cochrane review . The Cochrane review showed comparable decreases in mortality [RR 0.75 (95% CI 0.64, 0.88), RD −0.09 (95% CI −0.13, −0.04)] and morbidity in survivors at 18–24 months [RR 0.77 (95% CI 0.63, 0.94), RD −0.13 (95% CI −0.19, −0.07)].…”

Using a novel laminar flow unit provided effective total body hypothermia for neonatal hypoxic encephalopathy

“…The 26 infants were severely ill on admission and when they were enrolled to the study (Tables ). The severity of their conditions was similar to that described in other studies, with moderate or severe encephalopathy and intrapartum hypoxia–ischaemia with low Apgar scores, ongoing resuscitation, cord or arterial blood gas within one hour of birth with a pH of <7.1 and/or a base deficit in excess of 12 .…”

aEEG and neurologic exam findings correlate with hypoxic–ischemic brain damage severity in a piglet survival model

“…Our model demonstrated remarkable translational power. Despite the fact that our piglets were able to spontaneously breathe, eat and even walk, post-HI mortality in our experiment attained 25%, which was comparable to that described for similar models in piglets 10,12,18 but slightly superior to that reported for asphyxiated newborns with moderate encephalopathy 19 likely because in the experimental model piglets were not benefited from post-HI sustained critical care. In agreement, the HI insult led to a remarkable increase in brain cortex of cell death as well as Lac/NAA ratio-a well-known surrogate for HI brain damage in newborn animals and humans.…”

Therapeutic hypothermia for hypoxic ischaemic encephalopathy using low‐technology methods: a systematic review and meta‐analysis

“…The beneficial effect of LTTH described in our review is similar to that of TH using predominantly high‐technology methods, reported in the most recent Cochrane review . The Cochrane review showed comparable decreases in mortality [RR 0.75 (95% CI 0.64, 0.88), RD −0.09 (95% CI −0.13, −0.04)] and morbidity in survivors at 18–24 months [RR 0.77 (95% CI 0.63, 0.94), RD −0.13 (95% CI −0.19, −0.07)].…”

Using a novel laminar flow unit provided effective total body hypothermia for neonatal hypoxic encephalopathy

“…The 26 infants were severely ill on admission and when they were enrolled to the study (Tables ). The severity of their conditions was similar to that described in other studies, with moderate or severe encephalopathy and intrapartum hypoxia–ischaemia with low Apgar scores, ongoing resuscitation, cord or arterial blood gas within one hour of birth with a pH of <7.1 and/or a base deficit in excess of 12 .…”

aEEG and neurologic exam findings correlate with hypoxic–ischemic brain damage severity in a piglet survival model

“…Our model demonstrated remarkable translational power. Despite the fact that our piglets were able to spontaneously breathe, eat and even walk, post-HI mortality in our experiment attained 25%, which was comparable to that described for similar models in piglets 10,12,18 but slightly superior to that reported for asphyxiated newborns with moderate encephalopathy 19 likely because in the experimental model piglets were not benefited from post-HI sustained critical care. In agreement, the HI insult led to a remarkable increase in brain cortex of cell death as well as Lac/NAA ratio-a well-known surrogate for HI brain damage in newborn animals and humans.…”