Cooling Abolishes Neuronal Network Synchronization in Rat Hippocampal Slices

Javedan, Sam; Fisher, Robert S.; Eder, Hans G.; Smith, Kris A.; Wu, Jie

doi:10.1046/j.1528-1157.2002.40101.x

Cited by 43 publications

(29 citation statements)

References 34 publications

(63 reference statements)

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“…Our recordings indicate that a 1 °C npg change in temperature correlates with an alteration of oscillation frequency of 2.3 Hz (a 9.2% change per degree). Our results are in line with a previous report in interface slices [18] , which showed an 8.3% reduction in frequency per degree of change in CCh-induced oscillations, and another report in hippocampal slices [19] , which showed an 8.8% reduction per degree in tetanically evoked γ oscillations. Temperaturerelated changes in the oscillation frequency are likely associated with changes in inhibitory postsynaptic potential (IPSP) duration.…”

Section: Discussionsupporting

confidence: 94%

Temperature- and concentration-dependence of kainate-induced γ oscillation in rat hippocampal slices under submerged condition

Wang

Zhou

et al. 2012

Acta Pharmacol Sin

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Aim: Fast neuronal network oscillation at the γ frequency band (γ oscillation: 30-80 Hz) has been studied extensively in hippocampal slices under interface recording condition. The aim of this study is to establish a method for recording γ oscillation in submerged hippocampal slices that allows simultaneously monitoring γ oscillation and the oscillation-related intracellular events, such as intracellular Ca 2+ concentration or mitochondrial membrane potentials. Methods: Horizontal hippocampal slices (thickness: 300 μm) of adult rats were prepared and placed in a submerged or an interface chamber. Extracellular field recordings were made in the CA3c pyramidal layer of the slices. Kainate, an AMPA/kainate receptor agonist, was applied via perfusion. Data analysis was performed off-line. Results: Addition of kainate (25-1000 nmol/L) induced γ oscillation in both the submerged and interface slices. Kainate increased the γ power in a concentration-dependent manner, but the duration of steady state oscillation was reduced at higher concentrations of kainate. Long-lasting γ oscillation was maintained at the concentrations of 100-300 nmol/L. Under submerged condition, γ oscillation was temperature-dependent, with the maximum power achieved at 29 ºC. The induction of γ oscillation under submerged condition also required a fast rate of perfusion (5-7 mL/min) and showed a fast dynamic during development and after the washout. Conclusion: The kainite-induced γ oscillation recorded in submerged rat hippocampal slices is useful for studying the intracellular events related to neuronal network activities and may represent a model to reveal the mechanisms underlying the normal neuronal synchronizations and diseased conditions.

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Section: Discussionsupporting

confidence: 94%

Temperature- and concentration-dependence of kainate-induced γ oscillation in rat hippocampal slices under submerged condition

Wang

Zhou

et al. 2012

Acta Pharmacol Sin

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“…We did observe though a tendency to spreading depression while at Ͼ40°C, observing it in nine cases at an average temperature of 41.2°C (data not shown). The relation between increased synchronization and epilepsy is such that cooling has been used to treat epilepsy (Rothman 2009;Rothman et al 2005), since decreasing temperature from 34 to 21°C reduced synchronization in hippocampal slices (Javedan et al 2002;Motamedi et al 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Lowering temperature has been reported to decrease synchronization in the hippocampal network (Javedan et al 2002;Motamedi et al 2006) and, for that reason, it has been used to decrease epileptic activity (Rothman 2009;Rothman et al 2005). On the contrary, higher temperatures increase gamma synchronization in the hippocampus (Wu et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Temperature Modulation of Slow and Fast Cortical Rhythms

Reig

Mattia

Compte

et al. 2010

Journal of Neurophysiology

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Reig R, Mattia M, Compte A, Belmonte C, Sanchez-Vives MV. Temperature modulation of slow and fast cortical rhythms. J Neurophysiol 103: 1253-1261, 2010. First published December 23, 2009 doi:10.1152/jn.00890.2009. In the local cortical network, spontaneous emergent activity self-organizes in rhythmic patterns. These rhythms include a slow one (Ͻ1 Hz), consisting in alternation of up and down states, and also faster rhythms (10 -80 Hz) generated during up states. Varying the temperature in the bath between 26 and 41°C resulted in a strong modulation of the emergent network activity. Up states became shorter for warmer temperatures and longer with cooling, whereas down states were shortest at physiological (36 -37°C) temperature. The firing rate during up states was robustly modulated by temperature, increasing with higher temperatures. The sparse firing rate during down states hardly varied with temperature, thus resulting in a progressive merging of up and down states for temperatures around 30°C. Below 30°C and down to 26°C the firing lost rhythmicity, becoming progressively continuous. The slope of the down-to-up transitions, which reflects the speed of recruitment of the local network, was progressively steeper for higher temperatures, whereas wave-propagation speed exhibited only a moderate increase. Fast rhythms were particularly sensitive to temperature. Broadband highfrequency fluctuations in the local field potential were maximal for recordings at 36 -38°C. Overall, we found that maintaining cortical slices at physiological temperature is critical for the generated activity to be analogous to that in vivo. We also demonstrate that changes in activity with temperature were not secondary to oxygenation changes. Temperature variation sets the in vitro cortical network at different functional regimes, allowing the exploration of network activity generation and control mechanisms.

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“…Anti-inflammatory [4] and pain relieving [5] effects of low temperatures are also often indicated. Other re search supports significant benefits of cryogenic treat ments in curing of the peripheral nervous system and the muscular system [6][7][8][9], as well as the central nervous system [10][11][12]. A positive effect of low temperatures on the mental state has also been observed [13,14].…”

Section: Introductionmentioning

confidence: 91%

The influence of single whole body cryostimulation treatment on the dynamics and the level of maximal anaerobic power

Klimek¹,

Lubkowska²,

Szyguła³

et al. 2011

International Journal of Occupational Medicine and Environmental Health

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Objectives: The objective of this work was to determine the dynamics of maximal anaerobic power (MAP) of the lower limbs, following a single whole body cryostimulation treatment (WBC), in relation to the temperature of thigh muscles. Materials and Methods: The subjects included 15 men and 15 women with an average age (±SD) of 21.6±1.2 years. To evaluate the level of ana erobic power, the Wingate test was applied. The subjects were submitted to 6 WBC treatments at -130°C once a day. After each session they performed a single Wingate test in the 15, 30, 45, 60, 75 and 90th min after leaving the cryogenic chamber. The order of the test was randomized. All Wingate tests were preceded by an evaluation of thigh surface temperature with the use of a ther movisual camera. Results: The average thigh surface temperature (T av ) in both men and women dropped significantly after the whole body cryostimulation treatment, and next increased gradually. In women T av remained decreased for 75 min, whereas in men it did not return to the basal level until 90th min. A statistically insignificant decrease in MAP was observed in women after WBC. On the contrary, a non-significant increase in MAP was observed in men. The course of changes in MAP following the treatment was similar in both sexes to the changes in thigh surface temperature, with the exception of the period between 15th and 30th min. The shorter time to obtain MAP was observed in women till 90th min and in men till 45 min after WBC compared to the initial level. Conclusions: A single whole body cryostimulation may have a minor influence on short-term physical performance of supra maximal intensity, but it leads to improvement of velocity during the start as evidenced by shorter time required to obtain MAP.

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Cooling Abolishes Neuronal Network Synchronization in Rat Hippocampal Slices

Cited by 43 publications

References 34 publications

Temperature- and concentration-dependence of kainate-induced γ oscillation in rat hippocampal slices under submerged condition

Temperature- and concentration-dependence of kainate-induced γ oscillation in rat hippocampal slices under submerged condition

Temperature Modulation of Slow and Fast Cortical Rhythms

The influence of single whole body cryostimulation treatment on the dynamics and the level of maximal anaerobic power

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