Convulsive behavior in the rat.

Finger, Frank W.

doi:10.1037/h0056553

Cited by 69 publications

(21 citation statements)

References 134 publications

(410 reference statements)

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“…Finally, in terms of psychological fear reactions (Stainbrook, 1947), it is conceivable that increased Oa could reduce fear by easing postictal respiration, etc. Such psychological mechanisms, however, have not been well supported by the audiogenic-seizure literature (e.g., Bevan, 1955;Finger, 1947;Willott, 1974).…”

Section: Resultsmentioning

confidence: 99%

Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice.

Willott¹,

Henry²

1976

Journal of Comparative and Physiological Psychology

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Section: Resultsmentioning

confidence: 99%

Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice.

Willott¹,

Henry²

1976

Journal of Comparative and Physiological Psychology

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“…Selective absorptive capacity for Mg may be insufficient in some gerbils within a colony to maintain an adequate Mg balance if the food is a commercial ration. In comment on the composition of such diets, Finger (1947) concluded that they tend to keep animal colonies in an intermediate state of nutritional balance because of variations in assimilative efficiencies. Even when the diets are fortified with important dietary elements, some fraction of the animals so fed may be presumed to suffer from nutritional lack owing to metabolic deficiency.…”

Section: Discussionmentioning

confidence: 99%

Seizure episodes during open-field tests among Mongolian gerbils fed different combinations of minerals

Harriman

1980

Psychobiology

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Tonic-clonic convulsions characteristic of hypomagnesemic tetany were shown with greater frequency during open-field tests among gerbils undergoing simple dietary Mg deficiency than among controls deprived of all minerals. The greater effect from simple Mg deficiency may result from antagonistic activity of other minerral ions. Because seizures in acute hypomagnesemia resemble "spontaneous seizures" of apparently normal gerbils, there is a possibility that the latter animals may be afflicted with chronic hypomagnesemia of the "latent tetany" type ow:ng to an impairment in Mg metabolism. Apparently, the first indication that susceptibility to an endogenous disorder had emerged within American colonies of Mongolian gerbils was contained in a report by Marston and Chang (1965). These investigators found that handling provoked transient spasticity in the musculature of certain animals. Somewhat earlier, Schwentker (1963) had been able to conclude that gerbils in this country were free from any signs of spontaneous disease. Nonetheless, Marston and Chang's observation was confirmed in reports which described a more advanced disturbance involving tonic-clonic convulsions of varying severity (Robinson. 1968; Thiessen, Lindzey, & Friend, 1968; Zeman, 1967). These investigators found the affected gerbils to be healthy and free from any identifiable dietary need. Even so, some form of metabolic dysfunction may have underlain what were labeled "spontaneous seizures" by Thiessen et al. (1968). Noting the resemblance of so-called "spontaneous seizures" to hypomagnesemic tetany, Harriman (1974, 1978) provoked seizing among previously nonsusceptible gerbils by creating a simple dietary magnesium (Mg) deficiency. The symptom picture for seizing gerbils fed low-Mg diets resembles that seen in the "latent tetany" form of hypomagnesemia that results from conditions of feeding or impairment in Mg absorption (Fontenot, 1979; Littledike & Cox, 1979). Consequently, so-called "spontaneous seizures" may result from Mg deficiency produced either through some metabolic dysfunction or from selective dietary restriction. Nonetheless, even if hypomagnesemia were a predisposing condition, readiness to seize might easily result from disturbance of other ionic levels, particularly for cations Na, Ca, and K, which, together with Mg, importantly affect the irritability level of tissue (Loeb, 1905). The present study was undertaken to explore the relations be

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“…One was the appearance of reports which dealt with retrograde amnesia brought on by audiogenic seizures (Brady, Stebbins, & Galambos, 1953;Essman & Hamburgh, 1962;Maier & Wapner, 1944) or electroconvulsive shock (Adams & Lewis, 1962;Coons & Miller, 1960;Madsen & McGaugh, 1961). The other was the finding reported by several Es that rats often return to the box from which they have been removed immediately following a violent seizure (Finger, 1947).…”

mentioning

confidence: 92%

Audiogenic seizures: Are they remembered?

Stern¹,

Gollender²

1963

Journal of Comparative and Physiological Psychology

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37 rats, 18 susceptible to audiogenio seizures, were trained in a runway with a white curtain for 62 trials on water reinforcement (S D ). Then 15 additional S D trials were interspersed with 15 trials on which the curtain was black (S A ); different subgroups received (a) audiogenic seizures, (b) subconvulsive grid shock, or (c) simple delay in the goal box. A control group received no S A trials. Ss that received audiogenic seizures stopped entering the goal box after the 2nd seizure. Shocked Ss stopped after the 1st shock. The failure of the audiogenic Ss to keep running led to the rejection of the hypothesis that rats have amnesia for this seizure situation.

show abstract

Convulsive behavior in the rat.

Cited by 69 publications

References 134 publications

Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice.

Roles of anoxia and noise-induced hearing loss in the postictal refractory period for audiogenic seizures in mice.

Seizure episodes during open-field tests among Mongolian gerbils fed different combinations of minerals

Audiogenic seizures: Are they remembered?

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