Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer’s disease Drosophila model

Kizhakke, P Anupama; Olakkaran, Shilpa; Antony, Anet; Tilagul, K Siddanna; Hunasanahally, P Gurushankara

doi:10.1016/j.jchemneu.2017.10.002

Cited by 40 publications

(18 citation statements)

References 22 publications

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“…Some common species of this genus include Convolvulus lineatus L. (Berjano et al, ; Gapparov, Razzakov, Abdullabekov, & Aripova, ), Convolvulus prostratus Forssk. (Bihaqi, Sharma, Singh, & Tiwari, ; Kizhakke, Olakkaran, Antony, Tilagul, & Hunasanahally, ), Convolvulus althaeoides L. (Cabrita, ; Tawaha, Alali, Gharaibeh, Mohammad, & El‐Elimat, ), Convolvulus arvensis L. (Al‐Enazi, ), and Convolvulus pilosellifolius Desr. (Al‐Enazi, ; Al‐Rifai et al, ; Awaad et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…The pharmacological potential of these plants comes from their chemical constituents with biological activities. Pharmacological activities were reported on some Convolvulus species such as the use of C. pilosellifolius as an antiulcerogenic (Atta, Mohamed, Nasr, & Mouneir, ; Awaad et al, ), C. arvensis and C. pilosellifolius inhibited tumor growth (Al‐Enazi, ; Meng et al, ), and C. prostratus against Alzheimer's disease (Kizhakke et al, ) and treat stress‐induced neurodegeneration (Rachitha et al, ), while C. prostratus for preventing aluminum‐induced neurotoxicity (Bihaqi et al, ). Indeed, the significance of Convolvulus plants is not only for medicinal applications but also for ancient and religious significance because it reminded people of certain aspects of their gods and goddesses (Austin, ).…”

Section: Introductionmentioning

confidence: 99%

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Convolvulus plant—A comprehensive review from phytochemical composition to pharmacy

Salehi

Krochmal‐Marczak

Skiba

et al. 2019

Phytotherapy Research

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Convolvulus genus is a representative of the family of Convolvulaceae. Convolvulus plants are broadly distributed all over the world and has been used for many centuries as herbal medicine. Convolvulus genus contains various phytochemicals such as flavonoids, alkaloids, carbohydrates, phenolic compounds, mucilage, unsaturated sterols or terpenes, resin, tannins, lactones, and proteins. phytochemical composition, antimicrobial and antioxidant activities, application as food preservative, traditional medicine use, anticancer activities, and clinical effectiveness in human of Convolvulus plants. All the parts of Convolvulus plants possess therapeutic benefits; preliminary pharmacological data validated their use in traditional medicine. However, further preclinical and clinical experiments are warranted before any application in human health.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Convolvulus plant—A comprehensive review from phytochemical composition to pharmacy

Salehi

Krochmal‐Marczak

Skiba

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Interestingly, the Shankhpushpi syrup and its isolated compounds (Scopoletin and Bacoside A) also exhibited evident anti-oxidant activity as evaluated by using DPPH assay with average IC 50 value ranging from 0.94 -2.39% v/v (Jain et al, 2017;Rachitha et al, 2018). Furthermore, the aqueous extract of CP roots diminished the endogenous levels of reactive oxygen species in tauopathy flies as i n d u c e d b y o v e r e x p r e s s i o n o f t -p r o t e i n , t h e r e b y substantiating its oxidative stress ameliorative effect (Olakkaran and Antony, 2017).…”

Section: Anti-oxidant Activitymentioning

confidence: 72%

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Balkrishna¹,

Thakur²,

Varshney³

2020

Front. Pharmacol.

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Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system-Ayurvedait is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therapeutic properties, such as anxiolytic, neuroprotective, antioxidant, analgesic, immunomodulatory, antimicrobial, antidiabetic and cardioprotective activities. This medicinal herb has been reported to contain many bioactive phytoconstituents, such as, alkaloid (convolamine), flavonoid (kaempferol) and phenolics (scopoletin, b-sitosterol and ceryl alcohol), that have been ascribed to the observed medicinal properties. Several research teams across the globe have highlighted the neuro-pharmacological profile of C. prostratus, wherein, the neuroprotective, nootropic and neuro-modulatory roles have been described. Besides, role of C. prostratus extracts in neurodegeneration has been well demonstrated. Despite of such elaborative preclinical pharmacological profile, detailed clinical investigations and mechanistic mode-of-action studies of this important herb are yet to be executed. The present review is attempted to showcase the phytochemical profile, pharmacological attributes and medicinal information of C. prostratus; with comprehensive research gap analysis. It is hoped that the scientific update on the ethnomedicinal aspects of this herb would thrive research propagation and development of the CNS phytopharmaceuticals, originated from C. prostratus.

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“…It has been employed in treatment of dementia, phobias and insomnia, and successfully tried in PD cases 53 . C. pluricaulis also has been found to ameliorate tau induced neurotoxicity in Alzheimer's disease 54 . Our results suggest that C. pluricaulis majorly derives its neuroprotective properties through a robust antioxidant Sp.…”

Section: Discussionmentioning

confidence: 99%

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

et al. 2020

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Parkinson’s disease (PD) is a neuromotor disorder, primarily manifested by motor anomalies due to progressive loss of dopaminergic neurons. Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis. Involvement of oxidative stress in PD is further substantiated through ROS induced Parkinsonian models and elevated oxidative markers in clinical PD samples; thereby, making modulation of neuronal oxidative load as one of the major approaches in management of PD. Here we have found a potent antioxidant moiety Scopoletin (Sp), a common derivative in most of the nootropic herbs, with robust neuroprotective ability. Sp increased cellular resistance to ROS through efficient recycling of GSH to prevent oxidative damage. The Sp treated cells showed higher loads of reduced glutathione making them resistant to perturbation of antioxidant machinery or neurotoxin MPP+. Sp could restore the redox balance, mitochondrial function, and prevented oxidative damage, leading to recovery of dopaminergic neural networks and motion abilities in Drosophila genetic model of PD. Our data also suggest that Sp, in combination increases the therapeutic potency of L-DOPA by mitigating its chronic toxicity. Together, we highlight the possible ability of Sp in preventing oxidative stress mediated loss of dopaminergic neurons and at the same time enhance the efficacy of dopamine recharging regimens.

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Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer’s disease Drosophila model

Cited by 40 publications

References 22 publications

Convolvulus plant—A comprehensive review from phytochemical composition to pharmacy

Convolvulus plant—A comprehensive review from phytochemical composition to pharmacy

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model

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