Convex probe endobronchial ultrasound: historical, contemporary, and cutting-edge applications

Avasarala, Sameer K.; Aravena, Carlos; Almeida, Francisco A.

doi:10.21037/jtd.2019.10.76

Cited by 11 publications

(7 citation statements)

References 87 publications

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“…EBUS-TBNA advantageously provides access to a wide array of lymph node stations (2R, 2L, 3p, 4R, 4L, 7, 10R, 10L, 11s, 11i, 11L, 12R, 12L). A method for nodal identification using EBUS and proper biopsy order has previously been described [ 34 , 35 ]. In some cases, sampling of a centrally located primary parenchymal lesion is also possible [ 36 ].…”

Section: Tissue Specimen and Diagnostic Testingmentioning

confidence: 99%

NSCLC in the Era of Targeted and Immunotherapy: What Every Pulmonologist Must Know

et al. 2023

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The treatment of non-small cell lung cancer has dramatically changed over the last decade through the use of targeted therapies and immunotherapies. Implementation of these treatment regimens relies on detailed knowledge regarding each tumor’s specific genomic profile, underscoring the necessity of obtaining superior diagnostic tissue specimens. While these treatment approaches are commonly utilized in the metastatic setting, approval among earlier-stage disease will continue to rise, highlighting the importance of early and comprehensive biomarker testing at the time of diagnosis for all patients. Pulmonologists play an integral role in the diagnosis and staging of non-small cell lung cancer via sophisticated tissue sampling techniques. This multifaceted review will highlight current indications for the use of targeted therapies and immunotherapies in non-small cell lung cancer and will outline the quality of various diagnostic approaches and subsequent success of tissue biomarker testing. Pulmonologist-specific methods, including endobronchial ultrasound and guided bronchoscopy, will be examined as well as other modalities such as CT-guided transthoracic biopsy and more.

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Section: Tissue Specimen and Diagnostic Testingmentioning

confidence: 99%

NSCLC in the Era of Targeted and Immunotherapy: What Every Pulmonologist Must Know

et al. 2023

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“…Mediastinoscopy, conventional transbronchial needle aspiration (TBNA), EBUS-TBNA, transesophageal ultrasound-guided fine needle aspirate (FNA) using the EBUS scope (EUS-B) and transesophageal endoscopic ultrasound-guided (EUS)-FNA are options currently available for invasive mediastinal staging [6,7]. Table 2 summarizes lymph nodes routinely accessible by these different modalities [7,13 ▪ ,14,15,16 ▪ ,17–23].…”

Section: Invasive Mediastinal Stagingmentioning

confidence: 99%

“…1). A detailed description on how to identify specific nodes with EBUS has been previously described [13 ▪ ]. We would like to discuss some additional important points.…”

Section: Ebus-tbnamentioning

confidence: 99%

Lung cancer staging, the established role of bronchoscopy

Marshall

Kalanjeri

Almeida

2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewLung cancer is the leading cause of cancer-related deaths worldwide. In the absence of distant metastases, accurate mediastinal nodal staging determines treatment approaches to achieve most favourable outcomes for patients. Mediastinal staging differentiates N0/N1 disease from N2/N3 in surgical candidates. Likewise, presence of nodal involvement in nonsurgical candidates who are being considered for stereotactic body radiation therapy is also critical. This review article seeks to discuss the current options available for mediastinal staging in nonsmall cell lung cancer (NSCLC), particularly the role of bronchoscopy. Recent findingsAlthough several techniques are available to stage the mediastinum, bronchoscopy with EBUS-TBNA with or without EUS-FNA appears to be superior in most clinical situations based on its ability to concomitantly diagnose and stage at once, safety, accessibility to the widest array of lymph node stations, cost and low risk of complications. However, training and experience are required to achieve consistent diagnostic accuracy with EBUS-TBNA. SummaryEBUS-TBNA with or without EUS-FNA is considered the modality of choice in the diagnosis and staging of NSCLC in both surgical and nonsurgical candidates.

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“…The state-of-the-art procedure for examining the lymph nodes in lung-cancer patients draws on an endobronchial ultrasound (EBUS) bronchoscope [ 1 , 2 , 3 , 4 ]. The EBUS bronchoscope, also referred to as a convex-probe EBUS or linear EBUS bronchoscope, integrates two modalities into one device ( Figure 1 ): (1) videobronchoscopy, which gives video images of the airway walls (endoluminal surfaces); and (2) convex-probe EBUS, which gives 2D fan-shaped views of extraluminal structures situated outside the airways.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Registration for Image-Guided EBUS Bronchoscopy

et al. 2022

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The state-of-the-art procedure for examining the lymph nodes in a lung cancer patient involves using an endobronchial ultrasound (EBUS) bronchoscope. The EBUS bronchoscope integrates two modalities into one device: (1) videobronchoscopy, which gives video images of the airway walls; and (2) convex-probe EBUS, which gives 2D fan-shaped views of extraluminal structures situated outside the airways. During the procedure, the physician first employs videobronchoscopy to navigate the device through the airways. Next, upon reaching a given node’s approximate vicinity, the physician probes the airway walls using EBUS to localize the node. Due to the fact that lymph nodes lie beyond the airways, EBUS is essential for confirming a node’s location. Unfortunately, it is well-documented that EBUS is difficult to use. In addition, while new image-guided bronchoscopy systems provide effective guidance for videobronchoscopic navigation, they offer no assistance for guiding EBUS localization. We propose a method for registering a patient’s chest CT scan to live surgical EBUS views, thereby facilitating accurate image-guided EBUS bronchoscopy. The method entails an optimization process that registers CT-based virtual EBUS views to live EBUS probe views. Results using lung cancer patient data show that the method correctly registered 28/28 (100%) lymph nodes scanned by EBUS, with a mean registration time of 3.4 s. In addition, the mean position and direction errors of registered sites were 2.2 mm and 11.8∘, respectively. In addition, sensitivity studies show the method’s robustness to parameter variations. Lastly, we demonstrate the method’s use in an image-guided system designed for guiding both phases of EBUS bronchoscopy.

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Convex probe endobronchial ultrasound: historical, contemporary, and cutting-edge applications

Cited by 11 publications

References 87 publications

NSCLC in the Era of Targeted and Immunotherapy: What Every Pulmonologist Must Know

NSCLC in the Era of Targeted and Immunotherapy: What Every Pulmonologist Must Know

Lung cancer staging, the established role of bronchoscopy

Multimodal Registration for Image-Guided EBUS Bronchoscopy

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