Converting Hybrid Potato Breeding Science into Practice

Vries, Michiel E. de; Adams, J. R.; Eggers, Ernst-jan; Su, Ying; Stockem, Julia E.; Kacheyo, Olivia C.; Dijk, Luuk C. M. van; Khera, Pawan; Bachem, Christian W.B.; Lindhout, P.; Vossen, E.A.G. van der

doi:10.3390/plants12020230

Cited by 17 publications

(13 citation statements)

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“…Today, hybrid breeding at Solynta has reached a point where it is a viable breeding method, and the development of hybrid varieties for commercialization is well underway [28,29]. So far, the breeding program of Solynta focused on traits deemed to be of general importance, such as uniformity, tuber yield and processing quality.…”

Section: Solynta's Innovation Journeymentioning

confidence: 99%

“…An important policy issue in this context is the need for adjustment of global regulatory frameworks to the use and trade of hybrid true potato seed [29,63]. The official protocol for testing Distinctness, Uniformity and Stability (DUS) of tuber-based potato varieties has to be adapted to seed-based hybrid varieties.…”

Section: The Future Of Hybrid Potato In the Agro-industrial Contextmentioning

confidence: 99%

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Responsible Innovation in Plant Breeding: The Case of Hybrid Potato Breeding

Stemerding¹,

Beumer

Edelenbosch

et al. 2023

Plants

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As an emerging innovation, hybrid potato breeding raises high expectations about faster variety development and clean true potato seed as a new source of planting material. Hybrid breeding could, therefore, substantially contribute to global food security and other major sustainable development goals. However, its success will not only depend on the performance of hybrid potato in the field, but also on a range of complex and dynamic system conditions. This article is based on a multidisciplinary project in which we have studied the innovation dynamics of hybrid potato breeding and explored how these dynamics may shape the future of hybrid potato. Inspired by the approach of responsible innovation, we closely involved key players in the Dutch and international potato sector and other relevant actors in thinking about these potato futures. An important and recurrent theme in our work is the tension between the predominant commercial innovation dynamics in plant breeding and promises to respond to the global challenges of food security, agrobiodiversity and climate change. In this article, we, therefore, discuss responsible innovation strategies in (hybrid) potato breeding, which may help to bridge this tension and finally reflect on the implications for the field of plant breeding in general.

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Section: Solynta's Innovation Journeymentioning

confidence: 99%

Section: The Future Of Hybrid Potato In the Agro-industrial Contextmentioning

confidence: 99%

Responsible Innovation in Plant Breeding: The Case of Hybrid Potato Breeding

Stemerding¹,

Beumer

Edelenbosch

et al. 2023

Plants

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“…To circumvent this challenge, the potato breeding community is currently putting a lot of efforts in the conversion of the allogamous tetraploid germplasm into a diploid self-compatible germplasm. This new germplasm, compatible with inbreeding, should enable breeding strategies that preserve cumulative genetic gains and delivers true potato seeds (TPS) F1 varieties (Lindhout et al 2011; Jansky et al 2016; Zhang et al 2021; de Vries et al 2023). Alternatively, if recombination is supressed, as in the case of asynaptic StDMC1 RNAi mutants (Kumar et al 2023), the genetic makeup of the parents can be fixed and potentially transmitted to their offspring.…”

Section: Introductionmentioning

confidence: 99%

Desynapsis in potato is caused byStMSH4mutant alleles and leads to either highly uniform unreduced pollen or sterility

Clot

Klein

Koopman

et al. 2023

Preprint

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The balanced segregation of homologous chromosomes during meiosis is essential for fertility and is mediated by crossovers. A strong reduction of crossovers leads to desynapsis, a process in which pairing of homologous chromosomes is abolished before metaphase I. This results in a random segregation of univalent and the production of unbalanced and sterile gametes. However, if desynapsis is combined with another meiotic alteration that restitutes the first meiotic division, then uniform and balanced unreduced gametes, essentially composed of non-recombinant homologs, are produced. This mitosis-like division is of interest to breeders because it transmits most of the parental heterozygosity to the gametes. In potato, desynapsis is a recessive trait that was tentatively mapped to chromosome8. In this article, we have fine-mapped the position of the desynapsis locus and identifiedStMSH4, an essential component of the class I crossover pathway, as the most likely candidate gene. A seven base-pair insertion in the second exon ofStMSH4was found to be associated with desynapsis in our mapping population. We also identified a second allele with a 3820 base-pair insertion and confirmed that both alleles cannot complement each other. Such non-functional alleles appeared to be common in potato cultivars. More than half of the varieties we tested are carriers of mutational load at theStMSH4locus. With this new information, breeders can choose to remove desynaptic alleles from their germplasm to improve fertility or to use them to produce highly uniform unreduced gametes in alternative breeding schemes.

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“…Many practical questions remain to be answered to assess the viability and commercial relevance of innovative potato breeding schemes. Some of these questions are shared between the Fixation-Restitution breeding and the diploid F1 hybrid breeding strategies (de Vries et al, 2023) and include: "How to broaden and subdivide the diploid inbred germplasm into heterotic and market class specific groups? ", "What kind of marker system must be used to follow inbreeding and introgressions?"…”

Section: Remaining Questions and Practical Recommendationsmentioning

confidence: 99%

“…To circumvent this challenge, the potato breeding community is currently putting a lot of efforts in the conversion of the allogamous tetraploid germplasm into a diploid self-compatible germplasm. This new germplasm, compatible with inbreeding, should enable breeding strategies that preserve cumulative genetic gains and delivers true potato seeds (TPS) F1 varieties (de Vries et al, 2023;Jansky et al, 2016;Lindhout et al, 2011;Zhang et al, 2021). Alternatively, if recombination is supressed, as in the case of asynaptic StDMC1 RNAi mutants (Kumar et al, 2023), the genetic makeup of the parents can be fixed and potentially transmitted to their offspring.…”

Section: Introductionmentioning

confidence: 99%

Natural variation in potato sexual reproduction facilitates breeding

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The origin and widespread occurrence of Sli based self-compatibility in potato Chapter 3 46 High-density linkage map constructed from a skim sequenced diploid potato population reveals transmission distortion and QTLs for tuber yield and pollen shed Chapter 4 74Desynapsis in potato is caused by StMSH4 mutant alleles and leads to either highly uniform unreduced pollen or sterility Chapter 5 94Identification of two mutant JASON-RELATED genes associated with unreduced pollen production in potato Chapter 6 122 General discussion References 143Summary 167Acknowledgements 171 About the author 179Education statement recognition model (Kubo et al., 2010), the combined action of the SLFs encoded by one S-haplotype results in the recognition and degradation of all S-RNases except of the one encoded by their own haplotype. Hence, self-incompatibility occurs when the Shaplotype of the pollen matches either of the two S-haplotypes of the style. This elegant model also provides an explanation for the phenomenon of competitive interaction that allows tetraploid potatoes to become self-compatible (Olsder and Hermsen, 1976). When tetraploid clones produce diploid heteroallelic pollen that expresses two complementary sets of S-locus F-box proteins (SLFs), all S-RNases are ubiquitinated, which breaks down gametophytic self-incompatibility.Recently, self-compatible diploid potato clones were engineered by a knock-out of the gene encoding for the S-RNase (Enciso-Rodriguez et al., 2019;Ye et al., 2018). Furthermore, a self-compatible diploid clone bearing a naturally weakly expressed S-RNase was recently identified . Other cases of self-compatibility among S. tuberosum dihaploids were reported in earlier studies (De Jong and Rowe, 1971;Olsder and Hermsen, 1976), but the genetic and mechanistic basis of their selfcompatibility remained undetermined prior to this thesis. Despite those alternative options, the most widely used source of self-compatibility is the dominant gene Sli originally identified from a S. chacoense accession and located on chromosome 12 Hanneman, 1998a, 1998b). The causal gene behind Sli was recently shown to encode for a pollen-expressed F-box protein functioning as a general S-RNase inhibitor (Eggers et al., 2021;Ma et al., 2021).

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Converting Hybrid Potato Breeding Science into Practice

Cited by 17 publications

References 71 publications

Responsible Innovation in Plant Breeding: The Case of Hybrid Potato Breeding

Responsible Innovation in Plant Breeding: The Case of Hybrid Potato Breeding

Desynapsis in potato is caused byStMSH4mutant alleles and leads to either highly uniform unreduced pollen or sterility

Natural variation in potato sexual reproduction facilitates breeding

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