Conversion Rate of Essential Tremor to Essential Tremor Parkinson Disease

Louis, Elan D.; Berry, Diane S.; Ghanem, Ali; Cosentino, Stephanie

doi:10.1212/cpj.0000000000200162

Cited by 7 publications

(2 citation statements)

References 37 publications

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“…This suggests that there is a subset of patients with criteria for ET, thus presenting postural bilateral hand tremor, that are prone to develop PD in the long run. This is in accordance with longitudinal studies showing an increased incidence of PD in ET populations [ 23 ], and to neuropathological studies showing and excess of lewy-body pathology in ET patients [ 24 ] (although cerebellar Purkinje cell alterations, found in other cerebellar neurodegenerative disorders, seem to be the main neuropathological finding in ET [ 25 ]).…”

Section: Discussionsupporting

confidence: 90%

REM sleep behavior disorder and Prodromal Parkinson’s Disease in patients with Essential Tremor

Bugalho,

Meira,

Pinho

et al. 2024

Sleep Medicine: X

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Section: Discussionsupporting

confidence: 90%

REM sleep behavior disorder and Prodromal Parkinson’s Disease in patients with Essential Tremor

Bugalho,

Meira,

Pinho

et al. 2024

Sleep Medicine: X

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“…A recent postmortem study indicated that 1 in 4 ET cases have Lewy pathology (LP); in two-thirds, LP was observed in the LC [13,14]. In Parkinson's disease (PD), a related disorder [15,16], sleep disruption observed during the prodromal period may involve the deposition of LP in brainstem structures such as the LC.…”

Section: Introductionmentioning

confidence: 99%

Subjective Sleep Disturbance and Lewy Pathology: Data from a Cohort of Essential Tremor Brain Donors

Ghanem,

Berry,

Cosentino

et al. 2024

Neurodegener Dis

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Introduction: Sleep disturbances have been associated with essential tremor (ET). However, their pathophysiological underpinnings remain unknown. In this exploratory study, we examined the association between subjective sleep disturbances and the presence of Lewy pathology (LP) on postmortem brain examination in ET cases. Methods: Fifty-two ET cases enrolled in a prospective, longitudinal study were assessed over an average period of 42 months. Cases completed the Pittsburgh Sleep Quality Index (PSQI), which yields seven component scores (e.g., sleep quality, sleep latency). For each component score, we calculated the difference between the last score and the baseline score. Brains were harvested at death. Each had a complete neuropathological assessment, including extensive α-synuclein immunostaining. We examined the associations between baseline PSQI scores and the change in PSQI scores (last – first), and LP on postmortem brain examination. Results: ET cases had a mean baseline age of 87.1 ± 4.8 years. LP was observed in 12 (23.1%) of 52 cases; in 7 of these 12, LP was observed in the locus coeruleus (LC). Change in time needed to fall asleep (last – first sleep latency component score) was associated with presence of LP on postmortem brain examination – greater increase in sleep latency was associated with higher odds of LP (odds ratio = 2.98, p = 0.02). The greatest increase in sleep latency was observed in cases with LP in the LC (p = 0.04). Conclusion: In ET cases, increases in sleep latency over time could be a marker of underlying LP, especially in the LC.

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Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort

Ghanem,

Berry,

Burkes

et al. 2024

Annals of Neurology

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ObjectiveDespite recent attention to cognitive impairment in essential tremor, few studies examine rates of conversion to diagnoses of mild cognitive impairment and dementia. Development of dementia in essential tremor is associated with loss of functional ability and a doubling of mortality rate. This prospective, longitudinal study comprehensively reports the prevalence and incidence of, and the annual rates of conversion to, mild cognitive impairment and dementia in an essential tremor cohort.MethodsPatients underwent detailed cognitive assessments and were assigned diagnoses of normal cognition, mild cognitive impairment, or dementia. There were 222 patients at baseline (mean age = 79.3 ± 9.7 years), and 177 patients participated in follow‐up evaluations at 18, 36, 54, and 72 months (mean years of observation = 5.1 ± 1.7). Data were compared to those of historical controls and Parkinson disease patients.ResultsThe cumulative prevalence of dementia and average annual conversion rate of mild cognitive impairment to dementia were 18.5% and 12.2%, nearly three times higher than rates in the general population, and approximately one half the magnitude of those reported for Parkinson disease patients. The cumulative prevalence of mild cognitive impairment (26.6%) was almost double that of the general population, but less than that in Parkinson disease populations.InterpretationWe present the most complete exposition of the longitudinal trajectory of cognitive impairment in an essential tremor cohort yet presented. The prevalence of and conversion rates to dementia in essential tremor fall between those associated with the natural course of aging and the more pronounced rates observed in Parkinson disease. ANN NEUROL 2024

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Conversion Rate of Essential Tremor to Essential Tremor Parkinson Disease

Cited by 7 publications

References 37 publications

REM sleep behavior disorder and Prodromal Parkinson’s Disease in patients with Essential Tremor

REM sleep behavior disorder and Prodromal Parkinson’s Disease in patients with Essential Tremor

Subjective Sleep Disturbance and Lewy Pathology: Data from a Cohort of Essential Tremor Brain Donors

Prevalence of and Annual Conversion Rates to Mild Cognitive Impairment and Dementia: Prospective, Longitudinal Study of an Essential Tremor Cohort

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