Conversion of δ-Aminolævulinic Acid to Porphobilinogen in a Tissue System

The Biogenesis of Heme, Chlorophylls, and Bile Pigments

“…(197 (Fig. This important discovery was in agreement with the almost simultaneous finding that broken cell preparations of algae < 30 > or of hemolyzed erythrocytes < 52 > could catalyze the formation of protoporphyrin IX and other porphyrins from the mono-pyrrole porphobilinogen (XI, Fig. From the pattern of labeling found in heme which was synthesized by avian red cells supplied with carboxyl or methyl C 14 -labeled acetate, Shemin and Wittenberg < 258 > deduced that the carbon atoms of acetate passed through the Krebs cycle and probably were incorporated into porphyrin as and the relative intensities of the absorption bands are affected by the nature and arrangement of the substituents on the ^-positions of the pyrrole residues.…”

Protochlorophyll and Chlorophyll Biosynthesis in Cell-Free Systems from Higher Plants

“…That same year (1953) Drese! & Falk (23) reported the conversion of ALA to porphobilinogen by hemolyzed chicken erythrocytes. A year later Granick (54) confirmed the findings of Dresel & Falk and reported the conver sion of ALA to porphobilinogen by a colorless aqueous extract prepared from chicken erythrocytes.…”

In Vitro Pyrrole and Porphyrin Synthesis in Lead Poisoning and Iron Deficiency*

“…As a result of the efforts of a number of investigators, whose work is summarized in Figure 1, a pathway for the biosynthesis of heme has been outlined (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”