1997
DOI: 10.1016/s0091-6749(97)70236-7
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Conversion of the CD4 T cell profile from T-dominant type to T-dominant type after varicella-zoster virus infection in atopic dermatitis

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Cited by 46 publications
(39 citation statements)
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“…This may also apply to atopic disease, as suggested by the finding that infection by varicella-zoster virus in atopic dermatitis skin lesions induces local IL-12 production and converts a Th2 cytokine profile to a Th1 cytokine profile. It was found that both locally in the lesions and systemically in the peripheral blood, specific responses to mite allergens were shifted towards a Th1 phenotype [75]. This fits the concept of the recently proposed hygiene hypothesis, which states that the increased prevalence of atopic disorders is due to a decrease in the exposure to certain infectious microorganisms, as a result of a changing lifestyle and increased personal hygiene [76].…”
Section: Intervention Leading To Modified Cytokine Profilessupporting
confidence: 66%
“…This may also apply to atopic disease, as suggested by the finding that infection by varicella-zoster virus in atopic dermatitis skin lesions induces local IL-12 production and converts a Th2 cytokine profile to a Th1 cytokine profile. It was found that both locally in the lesions and systemically in the peripheral blood, specific responses to mite allergens were shifted towards a Th1 phenotype [75]. This fits the concept of the recently proposed hygiene hypothesis, which states that the increased prevalence of atopic disorders is due to a decrease in the exposure to certain infectious microorganisms, as a result of a changing lifestyle and increased personal hygiene [76].…”
Section: Intervention Leading To Modified Cytokine Profilessupporting
confidence: 66%
“…In favor of an immune aberration is the fact that NF, the most severe manifestation of soft tissue infection, tended to occur more commonly in association with chickenpox than in nonchickenpox cases. Furthermore, Fujimara et al 33 have presented evidence of a switch of the CD4 ϩ T cell profile in patients with varicella and underlying atopic dermatitis from a T H2 to a T H1 dominant type with a relative immunosuppression. TH1 cells produce interferon-␥ and interleukin 2 (IL-2) and promote cellular immunity, whereas TH2 cells produce IL-4, IL-5, IL-10, and IL-13 and promote humoral immunity.…”
Section: Discussionmentioning
confidence: 99%
“…A cause-and-effect relationship between IL-12 and IFN-γ expression may play a role in the conversion of type 2 T cells into IFN-γ-producing T cells that induce KC apoptosis in AD (15)(16)(17)58). In addition, virus infections and bacterial superantigens of AD skin may lead to IFN-γ secretion of skin-infiltrating T cells (14,58,59). Furthermore, KCs exhibited a relatively low threshold for FasR expression in response to IFN-γ, in the range of 0.1-1.0 ng/mL.…”
mentioning
confidence: 99%