Conversion of Supramolecular Clusters to Macromolecular Objects

Zubarev, Eugene R.; Pralle, Martin U.; Li, Leiming; Stupp, Samuel I.

doi:10.1126/science.283.5401.523

Cited by 163 publications

(116 citation statements)

References 25 publications

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“…SAPNSs are synthetic biological materials formed through the assembly of ionic self-complementary peptides (23)(24)(25)(26)(27)(28)(29)(30) and are designed by using alternating positive and negative L-amino acids that form highly hydrated scaffolds in the presence of physiological-concentration salts, i.e., saline, tissue culture media, physiological solutions, or human body fluids such as cerebrospinal fluid (23)(24)(25) (Fig. 1b).…”

Section: Self-assembling Peptide Nanofiber Scaffold (Sapns)mentioning

confidence: 99%

Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

Ellis-Behnke

Liang

You

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

754

490

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Nanotechnology is often associated with materials fabrication, microelectronics, and microfluidics. Until now, the use of nanotechnology and molecular self assembly in biomedicine to repair injured brain structures has not been explored. To achieve axonal regeneration after injury in the CNS, several formidable barriers must be overcome, such as scar tissue formation after tissue injury, gaps in nervous tissue formed during phagocytosis of dying cells after injury, and the failure of many adult neurons to initiate axonal extension. Using the mammalian visual system as a model, we report that a designed self-assembling peptide nanofiber scaffold creates a permissive environment for axons not only to regenerate through the site of an acute injury but also to knit the brain tissue together. In experiments using a severed optic tract in the hamster, we show that regenerated axons reconnect to target tissues with sufficient density to promote functional return of vision, as evidenced by visually elicited orienting behavior. The peptide nanofiber scaffold not only represents a previously undiscovered nanobiomedical technology for tissue repair and restoration but also raises the possibility of effective treatment of CNS and other tissue or organ trauma.

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Section: Self-assembling Peptide Nanofiber Scaffold (Sapns)mentioning

confidence: 99%

Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

Ellis-Behnke

Liang

You

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

754

490

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“…This concept leads to mushroom-shaped supramolecular amphiphiles. They are reported to self-assemble curiously in monolayers in a noncentrosymmetric fashion [419][420][421][422][423][424][425][426][427][428]. As the rods can be functionalized, the concept offers spontaneous noncentrosymmetric self-assembly and second-order nonlinear optical properties (Fig.…”

Section: Fig 324mentioning

confidence: 99%

“…3.24) [419][420][421][422][423][424][425][426][427][428]. The rods tend to aggregate mutually, but as the coils take up a larger lateral space, the packing becomes hindered.…”

Section: Fig 324mentioning

confidence: 99%

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Transport and Electro‐Optical Properties in Polymeric Self‐Assembled Systems

Ikkala¹,

Brinke²

2007

Macromolecular Engineering

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“…A substantial measure of supramolecular self-organization has already been achieved through specific design and fine-tuning of noncovalent interactions. A variety of supramolecular objects of nanometer size and low dimensionality, such as spheres (1), wires (2), stripes (3), rods (4), toroids (5), and dendrimers (6) have so far been produced. However, self-organization of size-defined objects greater than tens or, more rarely, hundreds of molecules represents a formidable challenge in technologically relevant environments such as surfaces or thin films.…”

mentioning

confidence: 99%

Self-organization of nano-lines and dots triggered by a local mechanical stimulus

Biscarini

Cavallini

Kshirsagar

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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When a local mechanical perturbation is applied to the surface of a thin film of a mechanically interlocked molecule (a rotaxane), the molecules self-organize into periodic arrays of discrete dots or lines. The dimensionality of the nanostructures depends on whether the mechanical stimulus acts along a 1D line or over a 2D area. The size (50 -500 nm) and periodicity (100 -600 nm) of the patterns are controlled solely by the film thickness. This selforganization at the mesoscopic scale occurs via a nucleationripening mechanism eased by the relatively low energy barriers of the intramolecular rearrangement introduced by the mechanical bond. The phenomenon can be exploited as a bottom-up nanofabrication method.bottom-up fabrication ͉ dynamics ͉ rotaxanes ͉ surfaces B ottom-up fabrication requires a hierarchical organization of materials that starts at the molecular level and reaches extended, mesoscopic-length scales. A substantial measure of supramolecular self-organization has already been achieved through specific design and fine-tuning of noncovalent interactions. A variety of supramolecular objects of nanometer size and low dimensionality, such as spheres (1), wires (2), stripes (3), rods (4), toroids (5), and dendrimers (6) have so far been produced. However, self-organization of size-defined objects greater than tens or, more rarely, hundreds of molecules represents a formidable challenge in technologically relevant environments such as surfaces or thin films. On the other hand, a host of organization phenomena at interfaces exhibit spatial correlations across several orders of spatial length scales. Examples are self-affine growth (7), wetting͞dewetting transitions (8), Ostwald ripening (9), spinodal decomposition (10), and breath figures (11). The spatial correlations of these interfacial phenomena, which would be extremely convenient to exploit in fabrication, have diverse origins that range from far-fromequilibrium growth conditions, to the presence of metastability, to the competition between intermolecular and surface interactions. Indeed, if possible, one would want to combine the supramolecular and the interfacial organization to obtain a deterministic assembly, where spatial correlations exist from a few molecular objects to mesoscopic constructs.Our aim was to find suitable molecular systems that would not stay steadily ''anchored'' to a surface but, instead, upon an external stimulus, would change the pattern of interactions, thereby providing the input for long-scale reorganization. This is the case of rotaxane thin films that self-organize into patterns of dots upon a thermal treatment (12).Rotaxanes consist of a macrocycle (molecular ring) mechanically interlocked with a dumbbell (13). Their dynamical properties (14, 15) have heralded them as attractive systems for a number of applications that include molecular switches (16, 17), nanorecording (18), and protection of electroluminescent emitters (19). Earlier, we have shown that films of three rotaxanes, stimulated locally with the tip of an a...

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Conversion of Supramolecular Clusters to Macromolecular Objects

Cited by 163 publications

References 25 publications

Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

Transport and Electro‐Optical Properties in Polymeric Self‐Assembled Systems

Self-organization of nano-lines and dots triggered by a local mechanical stimulus

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