Conversion of sterigmatocystin to aflatoxin B1 by

Scientific information on mycotoxins and natural plant toxicants

“…EFSA reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors to the biological activities of STC (Terao, 1983). Sterigmatocystin is one of the late intermediates in AF biosynthesis (Hsieh et al, 1973;Beasley, 1999;Singh and Hsieh, 1976;Barnes et al, 1994). In contrast to the considerable literature on AFB 1 , little information has been published on the metabolism and biochemical effects of STC.…”

Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination

“…Since NOR is the earliest and the first stable aflatoxin precursor in the aflatoxin biosynthetic pathway [62,63,64], this discovery led to the identification of other key aflatoxin intermediates and established the early step metabolites in the aflatoxin pathway. It provided the opportunity to isolate the first aflatoxin pathway gene that encoding a reductase for the conversion from NOR to eventually aflatoxins [63,65,66]. After the cloning of several important aflatoxin pathway genes, the aflatoxin pathway gene cluster was discovered in A. parasiticus and A. flavus [67].…”

The biosynthesis of polyketide-derived mycotoxins

“…This information was consistent with its precursor r6le in aflatoxin biosynthesis ( Figure 18). {14C}Sterigmatocystin is efficiently converted into aflatoxin B1 by cultures of A. parasiticus (60). In this spectrum the C( 1) and C (5) resonances were enhanced but showed no (1 3C, '3C) coupling, thus confirming that fission of acetate units occurred with the concomitant loss of methyl-derived acetate carbon atoms during the biosynthesis of aflatoxin B1.…”