“…However, the quantitative difference in conversion between the N-hydroxyamphetamine enantiomers as well as the inability of boiled enzyme to produce substantial amounts of oxime have been advocated to prove the enzymatic nature of the process 33 . The latter has been shown to be a P-450-independent reaction, since oxime formation from the hydroxylamine precursor was insensitive to the presence of CO, SKF 525A or DPEA and was unaffected by pretreatment of the animals with phenobarbital 35,121 . This finding is in accord with the observation that highly purified FMO can catalyze oxidation of primary alkylhydroxylamines to oximes 123 Oximes have been isolated along with primary hydroxylamines from incubation mixtures containing arylalkylamines 22,33,87,126 and related compounds 23 .…”