Conversion of Furans by Baeyer-Villiger Monooxygenases

Kumar, Hemant; Fraaije, Marco W.

doi:10.3390/catal7060179

Cited by 18 publications

(15 citation statements)

References 31 publications

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“…Cit-47 and Cit-51 are homologs of XanO4 which is identied to be Baeyer-Villiger monooxygenases (BVMOs). 28,29 The identical between XanO4 and Cit-47 and Cit-51 is 39.7% and 39.4% respectively.…”

Section: The Proposal Of Biosynthetic Pathway and The Identication Omentioning

confidence: 97%

Genome-based analysis of the type II PKS biosynthesis pathway of xanthones inStreptomyces caelestisand their antifungal activity

Liu

Gao

et al. 2019

RSC Adv.

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Section: The Proposal Of Biosynthetic Pathway and The Identication Omentioning

confidence: 97%

Genome-based analysis of the type II PKS biosynthesis pathway of xanthones inStreptomyces caelestisand their antifungal activity

Liu

Gao

et al. 2019

RSC Adv.

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“…A TEMPO-lipase system that was developed for HMF transformation was shown to effectively oxidize FA to FCA [89]. Kumar et al tested the ability of 15 different Bayer-Villinger monoxygenases (BVMOs) to oxidize FA [104]. Among them, a phenylacetone monooxygenase (PAMO, EC 1.14.13.92) was shown to convert FA to FCA as the main product, achieving a 60% conversion yield after 12 h. However, a small amount of another by-product of oxidation reaction, which was identified as the formyl ester, was observed.…”

Section: Oxidative Reactions For Famentioning

confidence: 99%

Novel Routes in Transformation of Lignocellulosic Biomass to Furan Platform Chemicals: From Pretreatment to Enzyme Catalysis

2020

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The constant depletion of fossil fuels along with the increasing need for novel materials, necessitate the development of alternative routes for polymer synthesis. Lignocellulosic biomass, the most abundant carbon source on the planet, can serve as a renewable starting material for the design of environmentally-friendly processes for the synthesis of polyesters, polyamides and other polymers with significant value. The present review provides an overview of the main processes that have been reported throughout the literature for the production of bio-based monomers from lignocellulose, focusing on physicochemical procedures and biocatalysis. An extensive description of all different stages for the production of furans is presented, starting from physicochemical pretreatment of biomass and biocatalytic decomposition to monomeric sugars, coupled with isomerization by enzymes prior to chemical dehydration by acid Lewis catalysts. A summary of all biotransformations of furans carried out by enzymes is also described, focusing on galactose, glyoxal and aryl-alcohol oxidases, monooxygenases and transaminases for the production of oxidized derivatives and amines. The increased interest in these products in polymer chemistry can lead to a redirection of biomass valorization from second generation biofuels to chemical synthesis, by creating novel pathways to produce bio-based polymers.

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“…6). The oxidation of DFF to FDCA is based on the Baeyer-Villiger-type reaction, where DFF is liable to peracid-driven oxidation [30]. In DFF oxidation, peracids were generated in situ by employing CaLB as the biocatalyst and alkyl esters as the acyl donors along with the addition of aqueous hydrogen peroxide under the required reaction conditions.…”

Section: Production Of Fdca From Dffmentioning

confidence: 99%

Amino‐functionalised mesoporous silica microspheres for immobilisation of Candida antarctica lipase B – application towards greener production of 2,5‐furandicarboxylic acid

Saikia

Kumar²,

Rathankumar

et al. 2020

IET nanobiotechnol.

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In the present study, amino-functionalised mesoporous silica microspheres were utilised as support for the covalent immobilisation of Candida antarctica lipase B (CaLB) for the subsequent production of 2,5-furandicarboxylic acid (FDCA) from 2,5-diformylfuran (DFF). Under the optimised operating conditions of pH 6.5, particle/enzyme ratio of 1.25:1.0 and glutaraldehyde concentration of 4 mM, a maximum CaLB immobilisation yield of 82.4% on silica microspheres was obtained in 12.25 h. The immobilised CaLB was used for the synthesis of alkyl esters, which were utilised along with hydrogen peroxide for FDCA synthesis. The biocatalytic conversion of 30 mM DFF dictated a 77-79% FDCA in 48 h at 30°C; where the turnover number and turnover frequency of immobilised CaLB were 6220.73 mol mol −1 and 129.59 h −1 , respectively, for ethyl acetate, against 6297.65 mol mol −1 and 131.2 h −1 , respectively, for ethyl butyrate. Upon examining the operational stability, the immobilised CaLB exhibited high stability till five cycles of FDCA production.

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Conversion of Furans by Baeyer-Villiger Monooxygenases

Cited by 18 publications

References 31 publications

Genome-based analysis of the type II PKS biosynthesis pathway of xanthones inStreptomyces caelestisand their antifungal activity

Genome-based analysis of the type II PKS biosynthesis pathway of xanthones inStreptomyces caelestisand their antifungal activity

Novel Routes in Transformation of Lignocellulosic Biomass to Furan Platform Chemicals: From Pretreatment to Enzyme Catalysis

Amino‐functionalised mesoporous silica microspheres for immobilisation of Candida antarctica lipase B – application towards greener production of 2,5‐furandicarboxylic acid

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