Conversion of ferritin ferrihydrite core to magnetite by gold ions binding and the derived nanoparticle formation

Tofanello, Aryane; Bronzato, Julia D.; Rettori, C.; Nascimento, Otaciro Rangel; Nantes, Iseli L.

doi:10.1007/s40097-021-00423-8

Cited by 2 publications

(1 citation statement)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A temperature above 65 • C and strongly alkaline pH, necessary for magnetite mineralization, cannot be achieved in living tissues [27]. The expected precursor may be an iron ferritin core composed of ferrihydrite-like minerals combined with an iron-overloading effect with the help of various additives [28]. The role of magnetite in human tissues can be associated with catalytic, signal, memory, or communication roles [29].…”

Section: Introductionmentioning

confidence: 99%

Variations in the Structural and Colloidal Stability of Magnetoferritin under the Impact of Technological Process Modulations

Balejcikova,

Zolochevska,

Tomasovicova

et al. 2023

Crystals

View full text Add to dashboard Cite

Iron-based materials, especially magnetite nanocrystals, have found extensive applications in many fields. Novel challenges focus on a deeper understanding of interactions between magnetite and biological macromolecules for developing further applications in diagnostic and treatment methods in medicine. Inspired by ferritin, the iron storage protein occurring in bacteria, plant, animal, and human cells, we developed an artificial ferritin-like material known as magnetoferritin. We present structural studies of magnetoferritin samples prepared using a controlled in vitro physicochemical synthesis. Considerable structural and size changes were observed by increasing the iron content and post-synthesis treatment. We propose the modulation of colloidal stability by using suitable solvents. Ultraviolet and visible spectroscopy, dynamic light scattering, colloidal stability measurements, infrared spectroscopy, and small-angle X-ray scattering methods were employed. The presented results aid in increasing the effectiveness of the various applications of magnetoferritin according to specific industrial requirements.

show abstract

Section: Introductionmentioning

confidence: 99%

Variations in the Structural and Colloidal Stability of Magnetoferritin under the Impact of Technological Process Modulations

Balejcikova,

Zolochevska,

Tomasovicova

et al. 2023

Crystals

View full text Add to dashboard Cite

show abstract

Effect of chiral silver nanoparticles on prolyl-oligopeptidase binding and activity

Batista,

Toledo,

Ramos

et al. 2024

Front. Nanotechnol.

View full text Add to dashboard Cite

Introduction: Silver nanoparticles have a diversity of applications both in biological and technological areas. More recently, studies conducted in the Nano/Bio interface have demonstrated that chiral nanocrystals grew in chiral templates, and nanostructures functionalized with chiral molecules present specific properties. These properties apply to advanced materials, energy, medicine, and pharmacology.Methodology: The present study synthesized silver nanoparticles on silver seeds using D- and L-histidine as templates and borohydride as a reducing agent.Results and Discussion: The nanoparticles were characterized by UV-visible spectroscopy and presented surface plasmon resonance (SPR) bands around 415 nm. CD spectra showed signals in the region of the SPR band, indicating the growth of nanocrystals with chiral distortion. Synthesized silver nanoparticles were also characterized by high-resolution transmission electron microscopy (HRTEM), which evidenced the presence of histidine corona. The silver nanoparticles were functionalized with prolyl-oligopeptidase (POP), a prolinespecific endopeptidase expressed in the brain. This enzyme cleaves neuroactive peptides involved in memory, learning, and neurodegeneration. The enzyme POP was expressed with a His-tag to provide competitive binding affinity to silver nanoparticles covered by D- and L-histidine. Considering the biological importance, POP was chosen as a model for studying the functionalization of chiral silver nanoparticles regarding the chiral discrimination for binding affinity and stabilization.

show abstract

Conversion of ferritin ferrihydrite core to magnetite by gold ions binding and the derived nanoparticle formation

Cited by 2 publications

References 89 publications

Variations in the Structural and Colloidal Stability of Magnetoferritin under the Impact of Technological Process Modulations

Variations in the Structural and Colloidal Stability of Magnetoferritin under the Impact of Technological Process Modulations

Effect of chiral silver nanoparticles on prolyl-oligopeptidase binding and activity

Contact Info

Product

Resources

About