Conversion of dopamine D1 receptors from high to low affinity for dopamine

Seeman, Philip; Ulpian, Carla; Grigoriadis, Dimitri E.; Pri‐Bar, Ilan; Buchman, Ouri

doi:10.1016/0006-2952(85)90116-9

Cited by 88 publications

(16 citation statements)

References 14 publications

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“…A study of the pre-vs. postsynaptic distributions of the DAD1 and DAD2 proteins in both mice and rats is called for. Species differences in the interconversion of DA receptors from high-to low-affinity states (Leff et al, 1985;Seeman et al, 1985) in response to changes in Na1 and GTP concentrations Hamblin and Creese, 1982;Makman et al, 1982;Watanabe et al, 1985) may also be held to account. High-affinity DAD2 receptor density is reported to be the best predictor of movement initiation in rats (Wilcox et al, 1988), and a similar mechanism has been postulated to account for differences in the response to apomorphine by different inbred mouse strains (Cabib and Puglisi-Allegra, 1985;Michaluk et al, 1982;Randall and Randall, 1986).…”

Section: Discussionmentioning

confidence: 97%

DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats

Halberda

Middaugh

Gard

et al. 1997

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Studies on rats indicate that DAD1- and DAD2-like agonists produce a biphasic action on motor activity, with low doses reducing activity below control levels, and higher doses initially reducing, then elevating, activity for a prolonged period. Although some of the reported effects of DAD1- and DAD2-like receptor agonists on motor activity of mice are consistent with their effects on rats, the possibility of species differences is also apparent. In the current study the effects of DAD1- and DAD2-like agonists on motor activity of C57BL/6 (C57) mice were determined to establish species consistencies and differences with respect to their effects on rats. The partial DAD1-like agonist SKF 38393 reduced the activity of C57 mice at low doses and elevated activity above control levels at higher doses, if the mice were thoroughly habituated to the test chamber. The full DAD1 agonist SKF 82958 also increased the activity of C57 mice, and along with the SKF 38393 results indicates a response to DAD1 receptor stimulation similar to that reported for rats. In contrast to the species similarity in response to DAD1 stimulation, the DAD2-like agonist quinpirole produced only a dose-responsive monotonic reduction in the activity of C57 mice, whether the animals were nonhabituated or well-habituated to the testing environment, male or female, young or mid-aged, injected intraperitoneally (i.p.) or subcutaneously (s.c.), and with either low or high doses. This apparent species difference in response to quinpirole might reflect distinguishable functional properties of the DA subreceptor systems.

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Section: Discussionmentioning

confidence: 97%

DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats

Halberda

Middaugh

Gard

et al. 1997

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“…Finally, pTA binding sites were highly concentrated in typically dopaminergic brain regions (Table 2). In fact, pharmacological characterization indicated apparent similarities between pTA and D3 (now Dbhigh) (Seeman, 1982;Seeman et al, 1985) (Burt et al, 1976), and rat (Heikkila et al, 1983) striatal membranes was poorly (IC50 approx. 10 p1M) displaced by pTA.…”

Section: Discussionmentioning

confidence: 99%

High affinity binding of [³H]‐tyramine in the central nervous system

Vaccari

1986

British J Pharmacology

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“…It is now generally accepted that there are two distinct types of DA receptors in the central nervous system (CNS): Di and D: in high-and low-affinity states [10,20,48,53]. The Di subtype is positively coupled to adenylate cyclase, while the D?…”

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confidence: 99%

Dopaminergic Neurones in the Zona incerta Exert a Stimulatory Control on Gonadotrophin Release via D<sub>1</sub> Dopamine Receptors

James¹,

Mackenzie²,

Tuohy-Jones³

et al. 1987

Neuroendocrinology

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The zona incerta (ZI) is a site of dopamine nerve terminals and part of the incertohypothalamic tract (I-H). Previous findings indicate that dopamine in the ZI has a stimulatory control on the release of luteinizing hormone (LH) and occurrence of ovulation. The effect of acute administration into anaesthetised rats of selective D₁ and D₂ dopamine agonists and antagonists injected into the ZI on plasma luteinizing hormone (LH) and on the occurrence of ovulation has now been investigated. It was found that bilateral injections on the day of pro-oestrus of a selective D₁ antagonist, Sch 23390, inhibited ovulation at 10 µg/side/rat. Unilateral injections of a selective D₁ agonist, SKF 38393, at 10 µg/rat stimulated a significant rise in plasma LH concentration in ovariectomised oestrogen-primed rats, and this was partially reversed by systemic pre-treatment with Sch 23390. The selective D₂ agonist, LY 171555, and D₂ antagonists, sulpiride and domperidone, had no effect on plasma LH levels or ovulation. This indicates that D₁ receptors (but not D₂ receptors) in the ZI are involved in the control of gonadotrophin release and may have a physiological function in reproductive processes.

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Conversion of dopamine D1 receptors from high to low affinity for dopamine

Cited by 88 publications

References 14 publications

DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats

DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats

High affinity binding of [³H]‐tyramine in the central nervous system

Dopaminergic Neurones in the Zona incerta Exert a Stimulatory Control on Gonadotrophin Release via D<sub>1</sub> Dopamine Receptors

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Conversion of dopamine D1 receptors from high to low affinity for dopamine

Cited by 88 publications

References 14 publications

DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats

DAD1- and DAD2-like agonist effects on motor activity of C57 mice: Differences compared to rats

High affinity binding of [3H]‐tyramine in the central nervous system

Dopaminergic Neurones in the Zona incerta Exert a Stimulatory Control on Gonadotrophin Release via D<sub>1</sub> Dopamine Receptors

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High affinity binding of [³H]‐tyramine in the central nervous system