Conversion of Diopterin and Teropterin into Folic and Folinic Acid Activity by the Rat Liver.

Cherrick, Gilbert R.; Baker, Herman; Frank, Oscar; Leevy, Carroll M.

doi:10.3181/00379727-113-28514

Cited by 5 publications

(1 citation statement)

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“…It is well known that the liver is a site rich in folate and the enzynies concerned in its metabolism (Buchanan, Elford, Loughlin, McDougall andRosenthal, 1964, particularly dihydrofolate reductase (Charache, Condit andHumphrey, 1960). Cherrick, Baker, Frank and Leevy (1963) have demonstrated the conversion of pteroylglutamyl-or-glutamic acid and pteroylglutamyl-y-glutamyl-y -glutamic acid (Diopterin and Teropterin) into folic and folinic acid in the perfuscd rat liver.…”

Section: Iiiscussionmentioning

confidence: 99%

Absorption of Unaltered Folic Acid, from the Gastro‐intestinal Tract in Man

Whitehead

Cooper

1967

Br J Haematol

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SUMMARY Hepatic portal and systemic plasma folate levels were determined in human subjects during umbilical‐vein catheterization after oral administration of folic acid. Hepatic‐vein blood was obtained during right heart catheterization. Serial folate measurements with L. casei and S. faecalis and TEAE‐cellulose chromatography revealed that folic acid is rapidly absorbed into the portal blood without undergoing metabolic conversion. A delay in rise in folate levels in systemic and hepatic‐vein blood, together with the finding of large amounts of folic acid and methylfolate in blood subsequently leaving the liver, indicates that this organ is the major site of folic‐acid metabolism.

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Section: Iiiscussionmentioning

confidence: 99%