Conversion of dietary trans-vaccenic acid to trans11,cis13-conjugated linoleic acid in the rat lactating mammary gland by Fatty Acid Desaturase 3-catalyzed methyl-end Δ13-desaturation

Garcia, Cyrielle; Guillocheau, Étienne; Richard, Léo; Drouin, Gaëtan; Catheline, Daniel; Legrand, Philippe; Rioux, Vincent

doi:10.1016/j.bbrc.2018.09.132

Cited by 13 publications

(9 citation statements)

References 29 publications

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“…2), a well-described step in both rodents (Santora et al, 2000;Gruffat et al, 2005;Kraft et al, 2006) and humans (Turpeinen et al, 2002;Kuhnt et al, 2006;Mosley et al, 2006). Our research group also demonstrated the D13-desaturation of TVA to obtain a conjugated trans-11, cis-13 C18:2 fatty acid (Rioux et al, 2013;Garcia et al, 2017Garcia et al, , 2018. Besides, TVA may be converted to the trans-13 C20:1 thanks to an elongation step (Rioux et al, 2013).…”

Section: Rumenic Acid (Rma)supporting

confidence: 52%

Benefits of natural dietarytransfatty acids towards inflammation, obesity and type 2 diabetes: defining the n-7transfatty acid family

Guillocheau

Legrand

Rioux

2019

OCL

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Natural trans fatty acids are trans fatty acids that naturally occur in ruminant-derived foods: milk (derived from cow, ewe, goat), dairy products (yoghurt, cheese) and ruminant meat (beef, lamb). Because natural trans fatty acids are part of the trans fatty acid family, they have been compared for decades to their industrial counterparts on a cardiovascular outcome’s basis. At current dietary intakes, it is now well recognized that natural trans fatty acids are neutral towards cardiovascular health. Still, the negative connotation remains. It is usually taken for granted in the scientific community that natural trans fatty acids have no known physiological function and therefore no particular nutritional interest. This prevailing view has totally hidden several studies, which pointed out unsuspected benefits of natural trans fatty acids on inflammation, type 2 diabetes and obesity. Some supplementation studies dealt with pure trans-vaccenic acid (trans-C18:1 n-7) and pure rumenic acid (cis-9, trans-11 C18:2), but remained somewhat aside as they were carried out on rodents. However, recent epidemiological data reached considerable impact, highlighting a protective effect of trans-palmitoleic acid (trans-C16:1 n-7) towards the risk of type 2 diabetes. Bearing in mind that natural trans fatty acids do not just consist of rumenic acid, this review is the opportunity to sum up scientific knowledge about each of these three fatty acids. We shall therefore, review their occurrence in foods, and their physiological impacts. An overlooked aspect of natural trans fatty acids is that they are metabolically connected. The second aim of this review is to underline these metabolic connections. In fact, combining physiological impacts and metabolic pathways unravel shared mechanisms of action of trans-palmitoleic, trans-vaccenic and rumenic acids, that might be explained by their common n-7 trans double bond.

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Section: Rumenic Acid (Rma)supporting

confidence: 52%

Benefits of natural dietarytransfatty acids towards inflammation, obesity and type 2 diabetes: defining the n-7transfatty acid family

Guillocheau

Legrand

Rioux

2019

OCL

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“…Surprisingly, recent in vitro studies demonstrated that the product of FADS3 in rat encodes the enzyme which can catalyze delta-13 desaturation of trans-vaccenic acid (VA, trans-11 18:1) to trans-11, cis-13 conjugated linoleic acid (CLA; trans-11, cis-13 18:2). Hence, FADS3 might be the first gene encoding methyl-end desaturase in mammals, but this concept still has not been confirmed in vivo [97,98]. What is interesting, some studies have shown that unsaturated fatty acid desaturases activity resulting from genetic variants of FADS genes can be masked.…”

Section: Role Of Unsaturated Fatty Acid Desaturases In Humans and Othmentioning

confidence: 99%

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

Czumaj

Śledziński

2020

Nutrients

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Polyunsaturated fatty acids (PUFAs) are considered one of the most important components of cells that influence normal development and function of many organisms, both eukaryotes and prokaryotes. Unsaturated fatty acid desaturases play a crucial role in the synthesis of PUFAs, inserting additional unsaturated bonds into the acyl chain. The level of expression and activity of different types of desaturases determines profiles of PUFAs. It is well recognized that qualitative and quantitative changes in the PUFA profile, resulting from alterations in the expression and activity of fatty acid desaturases, are associated with many pathological conditions. Understanding of underlying mechanisms of fatty acid desaturase activity and their functional modification will facilitate the development of novel therapeutic strategies in diseases associated with qualitative and quantitative disorders of PUFA.

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“…Recent studies have reported that there is an alternative pathway for the formation of CLA in non-ruminant animals, and it is through the FADS3 gene. This gene prevents the desaturation of trans-vaccenic acid and causes the production of the trans-11, cis-13 isomer of CLA [27].…”

Section: Synthesis Of Conjugated Linoleic Acid (Cla)mentioning

confidence: 99%

Relationship between the Composition of Lipids in Forages and the Concentration of Conjugated Linoleic Acid in Cow’s Milk: A Review

Balcazar

Rivera

Chavira

et al. 2022

Animals

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Conjugated linoleic acid (CLA), has been shown to have protective effects against various diseases, such as obesity, arteriosclerosis, diabetes, chronic inflammatory diseases, and cancer. This fatty acid in ruminants results from two processes, biohydrogenation, which takes place in the rumen, and de novo synthesis, carried out in the mammary gland, and it has linoleic and α-linolenic acids as its precursors. The amounts of precursors in the diets of animals are related to the amounts of CLA in milk. In the literature review, it was found that the milk of cows fed fresh forage has a higher amount of CLA because they have a higher amount of linoleic acid and α-linolenic acid compared to other foods used in the diets of cows. The amount of CLA precursors in pastures can be increased through agronomic practices, such as nitrogen fertilization, and regrowth age. It is also a technique used to increase the amount of CLA in milk to obtain a greater benefit regarding its nutritional value.

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Conversion of dietary trans-vaccenic acid to trans11,cis13-conjugated linoleic acid in the rat lactating mammary gland by Fatty Acid Desaturase 3-catalyzed methyl-end Δ13-desaturation

Cited by 13 publications

References 29 publications

Benefits of natural dietarytransfatty acids towards inflammation, obesity and type 2 diabetes: defining the n-7transfatty acid family

Benefits of natural dietarytransfatty acids towards inflammation, obesity and type 2 diabetes: defining the n-7transfatty acid family

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

Relationship between the Composition of Lipids in Forages and the Concentration of Conjugated Linoleic Acid in Cow’s Milk: A Review

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