Conversion of Deuterium Gas to Heavy Water by Catalytic Isotopic Exchange Using Wetproof Catalyst

Catalytic dehalogenation of aromatic halides using isotopic hydrogen gas is an important strategy for labelling pharmaceuticals, biochemicals, environmental agents and so forth. To extend, improve and further understand this process, studies have been carried out on the scrambling of deuterium isotope with protium during the catalytic deuterodehalogenation of model aryl chlorides using deuterium gas and a palladium on carbon catalyst in tetrahydrofuran solution. The degree of scrambling was greatest with electron‐rich chloroarene rings. The tetrahydrofuran solvent and the triethylamine base were not the source of the undesired protium; instead, it arose, substantially, from the water content of the catalyst, though other sources of protium may also be present on the catalyst. Replacement of the Pd/C catalyst with one prepared in situ by reduction of palladium trifluoroacetate with deuterium gas and dispersed upon micronised polytetrafluoroethylene led to much reduced scrambling (typically 0–6% compared with up to 40% for palladium on carbon) and to high atom% abundance, regiospecific labelling. The improved catalytic system now enables efficient polydeuteration via the dehalogenation of polyhalogenated precursors, making the procedure viable for the preparation of MS internal standards and, potentially, for high specific activity tritium labelling.

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Studies of hydrogen isotope scrambling during the dehalogenation of aromatic chloro‐compounds with deuterium gas over palladium catalysts

Lockley

Venanzi

Crane

2020

Labelled Comp Radiopharmac

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An assessment on hydrogen isotopes separation by liquid phase catalytic exchange process

Ionitã

Bucur

Ștefănescu

2015

J Radioanal Nucl Chem

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Based upon the authors' long experience and upon a literature review, this paper presents an assessment regarding up-to-date R&D activities related to development and application of liquid phase catalytic exchange (LPCE) technology for tritium separation from tritiated water, produced in fission and fusion nuclear reactors. The assessment is focused on key elements of the LPCE process, mixed catalytic packing and as a result of the assessment, few recommendations for selecting the most suitable mixed catalytic packing are given. A new improved mixed catalytic packing (COMPACK C-P 001) was manufactured and proposed to be used in the future Tritium Removal Facility from Cernavoda CANDU NPP (Romania).

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Synthesis and characterization of hydrophobic nickel catalyst supported on different oxides for continuous liquid phase catalytic exchange reaction

Diyan Mohd Ridzuan,

Victor Ayodele,

Najwa Abdul Talib

et al. 2024

Journal of Industrial and Engineering Chemistry

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Conversion of Deuterium Gas to Heavy Water by Catalytic Isotopic Exchange Using Wetproof Catalyst

Cited by 6 publications

References 2 publications

Studies of hydrogen isotope scrambling during the dehalogenation of aromatic chloro‐compounds with deuterium gas over palladium catalysts

Studies of hydrogen isotope scrambling during the dehalogenation of aromatic chloro‐compounds with deuterium gas over palladium catalysts

An assessment on hydrogen isotopes separation by liquid phase catalytic exchange process

Synthesis and characterization of hydrophobic nickel catalyst supported on different oxides for continuous liquid phase catalytic exchange reaction

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