Conversion of d-penicillaminato trinuclear to mononuclear palladium(ii) structure by diamine ligands: remarkable enantioselectivity toward racemic 1,2-cyclohexanediamine

Abstract

The reactions of an S-bridged trinuclear palladium(II) complex, [Pd(3)(D-pen-N,O,S)(3)] (D-H(2)pen = D-penicillamine), with ethylenediamine (en) and racemic (R,R/S,S) 1,2-cyclohexanediamine (chxn) in water gave mononuclear palladium(II) complexes, [Pd(D-pen-N,S)(en)] (1) and [Pd(D-pen-N,S)(chxn)] (2), respectively. Of two diastereomers, [Pd(D-pen-N,S)(R,R-chxn)] (2(R)) and [Pd(D-pen-N,S)(S,S-chxn)] (2(S)), possible for 2, 2(S) was exclusively isolated in a high yield.

The Treatment of Wilson's Disease, a Rare Genetic Disorder of Copper Metabolism

“…The first 2 weeks are critical for that small, but unpredictable number of patients who may undergo rapid deterioration …" 24 Walshe was the first to recognise the bidentate ligating properties of the sulfhydryl and amino groups in D-penicillamine. In addition, the carboxyl group can also co-ordinate with metals, and an example of D-penicillamine acting as a tridentate ligand is the coordination of Pd(II) in [Pd 3 (D-pen-N,O,S) 3 ] 25 . However, if the redox conditions permit, D-penicillamine can reductively chelate metals and with Cu(II) it forms mixed Cu(I)/Cu(II) cluster compounds.…”