Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration

Rozzini, Luca; Chilovi, Barbara Vicini; Conti, Marta Zaffira; Bertoletti, Erik; Delrio, Ilenia; Trabucchi, Marco; Padovani, Alessandro

doi:10.1002/gps.1816

Cited by 150 publications

(126 citation statements)

References 37 publications

(41 reference statements)

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“…Any NPS: Three small clinical studies found NPI total scores were not associated with risk of conversion from any type MCI to all cause dementia 42;43 or aMCI to AD 44 (pooled effect size 0.0, -0.39 to 0.40). A higher quality epidemiological study also found no association of total Neuropsychiatric Inventory (NPI) score with conversion from any type MCI to all cause dementia, after controlling for age and education 45 , while one small additional clinical study found that it did predict conversion from any type MCI to AD 46 .…”

Section: Neuropsychiatric Symptoms (Nps)mentioning

confidence: 99%

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Cooper¹,

Sommerlad²,

Lyketsos³

et al. 2015

AJP

418

314

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Objectives: Public health campaigns encouraging early help-seeking have increased rates of Mild Cognitive Impairment (MCI) diagnosis in Western countries, but we know little about how to treat or prognosticate dementia outcomes in persons with MCI. Method: We searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist. We meta-analysed findings from three or more studies. Results: We identified 76 eligible papers. Diabetes and prediabetes increased risk of conversion from amnestic MCI (aMCI) to Alzheimer's Dementia (AD); risk in treated versus untreated diabetes was lower in one study. Diabetes was also associated with increased risk of conversion from any type or non-amnestic MCI to all cause dementia. Metabolic syndrome and pre-diabetes predicted all cause dementia in people with aMCI and any type MCI respectively. Mediterranean diet decreased risk of conversion from aMCI to AD. Presence of neuropsychiatric symptoms or lower serum folate levels predicted conversion from any type MCI to all cause dementia, but less formal education did not. Depressive symptoms predicted conversion from any type MCI to dementia in epidemiological, but not clinical studies. Conclusions: Diabetes increased the risk of conversion to dementia. Other prognostic factors that are potentially manageable are pre-diabetes and the metabolic syndrome, neuropsychiatric symptoms and low dietary folate. Dietary interventions and interventions to reduce neuropsychiatric symptoms including depression, which increase conversion risk to dementia, may decrease incident dementia.

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Section: Neuropsychiatric Symptoms (Nps)mentioning

confidence: 99%

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Cooper¹,

Sommerlad²,

Lyketsos³

et al. 2015

AJP

418

314

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“…Pathologically, MCI brain shows mild degradation of the hippocampus, entorhinal cortex, sulci, and gyri as evaluated by using magnetic resonance imaging (MRI) technology (54), while early and late stage AD patients have considerably greater degradation in these areas (61). It is estimated that the rate of conversion of amnestic MCI to AD is roughly 10%-15% per year (173); however, in some cases individuals with MCI can revert to normal (153).…”

Section: G93amentioning

confidence: 99%

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

Perluigi

Coccia

Butterfield

2012

Antioxidants & Redox Signaling

181

133

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Significance: Among different forms of oxidative stress, lipid peroxidation comprises the interaction of free radicals with polyunsaturated fatty acids, which in turn leads to the formation of highly reactive electrophilic aldehydes. Among these, the most abundant aldehydes are 4-hydroxy-2-nonenal (HNE) and malondialdehyde, while acrolein is the most reactive. HNE is considered a robust marker of oxidative stress and a toxic compound for several cell types. Proteins are particularly susceptible to modification caused by HNE, and adduct formation plays a critical role in multiple cellular processes. Recent Advances: With the outstanding progress of proteomics, the identification of putative biomarkers for neurodegenerative disorders has been the main focus of several studies and will continue to be a difficult task. Critical Issues: The present review focuses on the role of lipid peroxidation, particularly of HNE-induced protein modification, in neurodegenerative diseases. By comparing results obtained in different neurodegenerative diseases, it may be possible to identify both similarities and specific differences in addition to better characterize selective neurodegenerative phenomena associated with protein dysfunction. Results obtained in our laboratory and others support the common deregulation of energy metabolism and mitochondrial function in neurodegeneration. Future Directions: Research towards a better understanding of the molecular mechanisms involved in neurodegeneration together with identification of specific targets of oxidative damage is urgently required. Redox proteomics will contribute to broaden the knowledge in regard to potential biomarkers for disease diagnosis and may also provide insight into damaged metabolic networks and potential targets for modulation of disease progression. Antioxid. Redox Signal. 17, 1590-1609.

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“…57 It is interesting to note that worsening of memory impairment was not shown to be a major predictor of MCI conversion in a large longitudinal study. 58 In this study, the emergence of executive dysfunction during follow-up was the most important determinant of conversion from MCI to AD. This finding highlights the importance of careful assessment of other cognitive domains beyond memory in these individuals.…”

Section: Longitudinal Studies and MCI Prognosismentioning

confidence: 99%

Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia

Forlenza

Diniz

Stella

et al. 2013

Rev. Bras. Psiquiatr.

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Objective: To critically review and evaluate existing knowledge on the conceptual limits and clinical usefulness of the diagnosis of mild cognitive impairment (MCI) and the neuropsychological assessment and short-and long-term prognosis thereof. Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012. Based on the search terms mild cognitive impairment or MCI and epidemiology or diagnosis, we retrieved 1,698 articles, of which 248 were critically eligible (cross-sectional and longitudinal studies); the abstracts of the remaining 1,450 articles were also reviewed. Results: A critical review on the MCI construct is provided, including conceptual and diagnostic aspects; epidemiological relevance; clinical assessment; prognosis; and outcome. The distinct definitions of cognitive impairment, MCI included, yield clinically heterogeneous groups of individuals. Those who will eventually progress to dementia may present with symptoms consistent with the definition of MCI; conversely, individuals with MCI may remain stable or return to normal cognitive function. Conclusion: On clinical grounds, the cross-sectional diagnosis of MCI has limited prognostic relevance. The characterization of persistent and/or progressive cognitive deficits over time is a better approach for identification of cases at the pre-dementia stages, particularly if these cognitive abnormalities are consistent with the natural history of incipient Alzheimer's disease.

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Conversion of amnestic Mild Cognitive Impairment to dementia of Alzheimer type is independent to memory deterioration

Abstract: In subjects with aMCI poor global cognitive performance at baseline, the worsening on executive functions and on functional status but not the worsening on memory functions are independently associated with the conversion to dementia of Alzheimer type at 1 year, follow-up.

Cited by 150 publications

References 37 publications

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Modifiable Predictors of Dementia in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

Mild cognitive impairment (part 1): clinical characteristics and predictors of dementia

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