Conversion From Neoral (Cyclosporine) to Tacrolimus of Kidney Transplant Recipients for Gingival Hyperplasia or Hypertrichosis

Busque, S.; Demers, Philippe; St-Louis, G; Boily, J. G.; Tousignant, J; LeMieux, Frederick; Smeesters, C; Corman, J; Daloze, Pierre

doi:10.1016/s0041-1345(98)00229-2

Cited by 41 publications

(23 citation statements)

References 5 publications

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“…The dosage of CyA, duration of therapy as well as plasmatic and salivary concentrations of CyA play a central role. In addition, many other factors such as standards of oral hygiene, age, genetic predisposition, gingival infl ammation, some growth factors, especially TGF β and synergic or protective eff ects of other prescribed drugs contribute to the development of gingival hyperplasia 7,28 . Gingival hyperplasia and hypertrichosis usually regressed completely within several months after switch from CyA to tacrolimus in the majority of patients effected.…”

Section: Discussionmentioning

confidence: 99%

“…Gingival hyperplasia and hypertrichosis usually regressed completely within several months after switch from CyA to tacrolimus in the majority of patients effected. Residual gingival hyperplasia may persist in some individuals but is generally asymptomatic and requires no further specifi c dental treatment 7 . In our study gingival hyperplasia and hypertrichosis signifi cantly or completely resolved in all patients converted to tacrolimus.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperlipidemia and hypertension are also risk factors for chronic transplant nephropathy and reduce long term graft function and survival 5,6 . Gingival hyperplasia and hypertrichosis are known to reduce quality of life and may lead to non-compliance 7 . The above mentioned negative side eff ects associated with CyA can be substantially reduced by switching to tacrolimus based therapy.…”

Section: Improvement Of Cardiovascular Risk Factors and Cosmetic Sidementioning

confidence: 99%

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Improvement of Cardiovascular Risk Factors and Cosmetic Side Effects in Kidney Transplant Recipients After Conversion to Tacrolimus

Zadrazil¹,

Horák²,

Zahálková³

et al. 2009

BIOMED PAP

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Aims:Tacrolimus and Cyclosporine A (CyA) are cornerstones in immunosuppressive therapy. Cyclosporine side eff ects include hypertension and hypercholesterolemia both of which may increase the risk of cardiovascular mortality, gingival hyperplasia and hirsutism are known to reduce quality of life. The aim of this prospective study was to evaluate changes in cardiovascular risk profi le and cosmetic side eff ects after conversion from CyA to tacrolimus.Methods: 25 stable kidney transplant recipients (9 male, 16 female) were converted from a CyA to a tacrolimusbased regimen. Mean age was 45.7 ± 13.5 years. Time to switch following transplantation was 4.7±1.7 years. Reasons for conversion were multiple: arterial hypertension (9), hypertrichosis (3), gingival hyperplasia (3), hyperlipidemia (14).Results: 19/25 patients completed the one year study period. One patient died, two returned to hemodialysis, two were switched back to CyA and one patient was lost to follow-up. There were statistically signifi cant changes (p = < 0.05) in systolic and diastolic pressure and antihypertensive medication could be reduced in 13 patients. The dose of lipid-lowering agents could be reduced in the majority of the recipients and a complete withdrawal was achieved in 7 patients. Hypertrichosis and gingival hyperplasia resolved in all patients. Further, there was a signifi cant improvement (p = <0.05) in urea and serum creatinine levels. Adverse events were consistent with the established safety profi le for tacrolimus.Conclusions: Conversion to a tacrolimus-based regimen led to an improvement in the cardiovascular risk profi le. Further, cosmetic side eff ects which may lead to non-compliance, resolved after the switch.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Improvement Of Cardiovascular Risk Factors and Cosmetic Sidementioning

confidence: 99%

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Improvement of Cardiovascular Risk Factors and Cosmetic Side Effects in Kidney Transplant Recipients After Conversion to Tacrolimus

Zadrazil¹,

Horák²,

Zahálková³

et al. 2009

BIOMED PAP

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“…Çocuk ve adolesanlar orta ve şiddetli hipertrikoz için en fazla riske sahiptir. Hipertrikoz ilaç kesildikten sonra 1-2 ay içinde geriler (3,28).…”

Section: İlaçla İlişkili Edinsel Generalizeunclassified

Hypertrichosis in Childhood

Dilek¹,

Bahadır²

2018

tdd

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Hipertrikoz, bir bireyde yaşı ve cinsiyetine göre normalden fazla ve aşırı miktarda kıl büyümesidir. Hipertrikozda kıl büyümesi androjen bağımlı değildir ve erkek tipi kıl büyümesini içermez. Bu özelliği ile hirsutismustan ayrılır. Bu derlemede çocuklarda görülen hipertrikoz; generalize hipertrikoz ve lokalize hipertrikoz olmak üzere 2 ana başlık altında incelenecektir. Ayrıca generalize hipertrikoz ve lokalize hipertrikoz; konjenital ve akiz alt başlıkları altında sunulacaktır. Anahtar kelimeler: Hipertrikoz, çocuk, generalize, lokalize, konjenital, akiz Nursel Dilek, Sevgi Bahadır* Çocukluk Çağında Hipertrikoz Hypertrichosis in Childhood Öz AbstractHypertrichosis is more than normal and excessive hair growth according to individual's age and sex. In hypertrichosis, hair growth is not androgen dependent and does not include male type hair growth. Hypertrichosis differentiates from hirsutism with this feature. In this review, childhood hypertrichosis will be examined under two main headings as generalized hypertrichosis and localized hypertrichosis. Also, generalized hypertrichosis and localized hypertrichosis will be presented with congenital and acquired sub headings.

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“…Discontinuing cyclosporine leads to resolution of excess hair in 1 to 2 months. 4,[8][9][10][11] Alternatives to cyclosporine including tacrolimus and sirolimus have lower rates of hypertrichosis. 12 Excess hair can be removed by various methods.…”

mentioning

confidence: 99%

Preferred methods of excess hair removal in pediatric patients with lung transplantation

Fisher

Berk

Greene

et al. 2006

Journal of the American Academy of Dermatology

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Conversion From Neoral (Cyclosporine) to Tacrolimus of Kidney Transplant Recipients for Gingival Hyperplasia or Hypertrichosis

Cited by 41 publications

References 5 publications

Improvement of Cardiovascular Risk Factors and Cosmetic Side Effects in Kidney Transplant Recipients After Conversion to Tacrolimus

Improvement of Cardiovascular Risk Factors and Cosmetic Side Effects in Kidney Transplant Recipients After Conversion to Tacrolimus

Hypertrichosis in Childhood

Preferred methods of excess hair removal in pediatric patients with lung transplantation

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