Conversion From Mild Cognitive Impairment to Probable Alzheimer’s Disease Predicted by Brain Magnetic Resonance Spectroscopy

Modrego, Pedro J.; Fayed, Nicolás; Pina, M. A.

doi:10.1176/appi.ajp.162.4.667

Cited by 124 publications

(71 citation statements)

References 35 publications

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“…These data confirmed previous evidence suggesting that decreased NAA/Cr levels predict future conversion to AD in subjects with MCI [26,86]. It was recently reported that while there were no differences in NAA/Cr, Cho/Cr and mI/Cr at baseline between stable MCI and MCI who converted to AD after a median follow-up period of thirteen months, the annualized rate of change in Cho/Cr ratio was greater in stable MCI compared to converter MCI and cognitively normal controls, suggesting a possible compensatory mechanism in stable MCI [61].…”

Section: Predictors Of Progression Of MCI To Dementiasupporting

confidence: 91%

Mild Cognitive Impairment: A Systematic Review

Mariani

Monastero

Mecocci

2007

JAD

209

188

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Abstract. MCI is a nosological entity proposed as an intermediate state between normal aging and dementia. The syndrome can be divided into two broad subtypes: amnestic MCI (aMCI) characterized by reduced memory, and non-amnestic MCI (naMCI) in which other cognitive functions rather than memory are mostly impaired. aMCI seems to represent an early stage of AD, while the outcomes of the naMCI subtypes appear more heterogeneous -including vascular dementia, frontotemporal dementia or dementia with Lewy bodies-but this aspect is still under debate. MCI in fact represents a condition with multiple sources of heterogeneity, including clinical presentation, etiology, and prognosis. To improve classification and prognosis, there is a need for more sensitive instruments specifically developed for MCI as well as for more reliable methods to determine its progression or improvement. Current clinical criteria for MCI should be updated to include restriction in complex ADL; also the diagnostic and prognostic role of behavioral symptoms and motor dysfunctions should be better defined. A multidisciplinary diagnostic approach including biological and neuroimaging techniques may probably represent the best option to predict the conversion from MCI to dementia. In this review we discuss the most recent aspects related to the epidemiological, clinical, neuropathological, neuroimaging, biochemical and therapeutic aspects of MCI, with specific attention to possible markers of conversion to dementia.

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Section: Predictors Of Progression Of MCI To Dementiasupporting

confidence: 91%

Mild Cognitive Impairment: A Systematic Review

Mariani

Monastero

Mecocci

2007

JAD

209

188

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“…MRSI could also help in the prediction from MCI to dementia. Some studies have reported lower NAA/Cr [153][154][155][156][157] and higher Cho/Cr [158] levels in several brain regions in MCI patients who developed dementia than stable MCI subjects. Nevertheless, some disagree with these findings [159,160] so further research is needed to verify MRSI's predictability from MCI to AD.…”

Section: Magnetic Resonance Spectroscopic Imaging (Mrsi)mentioning

confidence: 99%

On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

Alberdi

Aztiria

Basarab

2016

Artificial Intelligence in Medicine

162

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“…The neuronal integrity marker N-acetylaspartartate (NAA) and NAA/creatine (Cr) levels on 1 H MRS are lower in AD compared to normal elderly subjects [46], and decreased NAA/ Cr levels predict future conversion to AD in aMCI [6,30,34]. Furthermore, decreased NAA levels in other neurological disorders such as epilepsy [15], head trauma [3], and multiple sclerosis [25,36] may recover after successful treatment.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease

Kantarci¹,

Weigand²,

Petersen³

et al. 2007

Neurobiology of Aging

178

131

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Magnetic Resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD). Longitudinal changes in 1 H MR spectroscopy ( 1 H MRS) metabolite markers have not been characterized in aMCI subjects. Our objective was to determine the longitudinal 1 H MRS metabolite changes in patients with aMCI, and AD, and to compare 1 H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker Nacetylaspartate/Creatine ratio declined in aMCI and AD patients compared to cognitively normal elderly. The changein 1 H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that 1 H MRS metabolite ratios may be useful markers for the progression of AD. Choline/Creatine ratio declined in stable aMCI, compared to converter aMCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in aMCI patients who did not to progress to AD.

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Conversion From Mild Cognitive Impairment to Probable Alzheimer’s Disease Predicted by Brain Magnetic Resonance Spectroscopy

Abstract: MRS of the brain performed on patients with mild cognitive impairment is a valuable tool in predicting conversion to probable Alzheimer's disease. Occipital values were more reliable than hippocampal values in this prediction.

Cited by 124 publications

References 35 publications

Mild Cognitive Impairment: A Systematic Review

Mild Cognitive Impairment: A Systematic Review

On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease

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