Conversations between kingdoms: small RNAs

Weiberg, Arne; Bellinger, Marschal; Jin, Hailing

doi:10.1016/j.copbio.2014.12.025

Cited by 130 publications

(98 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to sRNA trafficking within an organism, recent studies indicate that sRNAs can move between a host and interacting pathogens or parasites to induce gene silencing through a phenomenon called “cross-kingdom RNAi” [31,32]. …”

Section: Cross-kingdom Srna Trafficking From Pathogens and Parasites mentioning

confidence: 99%

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Wang

Thomas

Jin

2017

Current Opinion in Plant Biology

Self Cite

100

View full text Add to dashboard Cite

Small RNA (sRNA)-induced RNA interference (RNAi) is an important conserved mechanism that modulates gene expression in almost all eukaryotes. Some sRNAs move short distances from cell to cell, while some travel long distances to spread systemically throughout the organism. Recent studies indicate that sRNAs can even move between organisms to induce gene silencing, a phenomenon called “cross-kingdom RNAi”. sRNA trafficking between a pathogen, pest, or symbiont and its respective host can have a significant impact on interaction compatibility. Certain sRNAs were found to travel from pathogens or pests into host cells and suppress host immunity to achieve successful infection in both plants and animals; while sRNAs generated from host cells also translocate into pathogen or parasite cells to inhibit their virulence. Such cross-kingdom RNAi mechanisms enable the development of efficient disease control methods using plant-derived RNAs that target essential genes of pathogens and pests. Moreover, uptake of exogenous RNAs from the environment was recently discovered in certain fungal pathogens, which makes it possible to suppress fungal diseases by directly applying pathogen–targeting RNAs on crops and post-harvested products to avoid extensive chemical treatment and circumvent generating genetically modified plants. This spray-induced gene silencing (SIGS) strategy is environmentally sustainable and friendly, and can be easily adapted to control multiple fungal diseases simultaneously.

show abstract

Section: Cross-kingdom Srna Trafficking From Pathogens and Parasites mentioning

confidence: 99%

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Wang

Thomas

Jin

2017

Current Opinion in Plant Biology

Self Cite

100

View full text Add to dashboard Cite

show abstract

“…Meeting this challenge will require developing groundbreaking strategies that promote sustainable plant production. Recent discoveries that animals and plants can deliver small (s)RNAs into interacting organisms thereby targeting their virulence functions has opened up new avenues for disease control (for recent reviews see Weiberg et al 2015;Guo et al 2016;Cai et al 2018): A recent breakthrough study has shown that pathogenderived sRNAs can move into host cells to suppress host immunity (Weiberg et al 2013). The grey mold pathogen Botrytis cinerea (Bc) produces sRNA effectors, which can migrate into and down-regulate Arabidopsis and tomato genes involved in disease resistance.…”

Section: Introductionmentioning

confidence: 99%

RNA-based disease control as a complementary measure to fight Fusarium fungi through silencing of the azole target Cytochrome P450 Lanosterol C-14 α-Demethylase

2018

View full text Add to dashboard Cite

show abstract

“…Remarkably, some sRNAs are mobile signals in plants that transmit gene silencing from cell to cell, or systemically over a long distance [7-10]. Recent attention has been focused on mobile sRNAs that mediate cross-kingdom RNAi in host-pathogen interactions [3,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Small RNAs — the secret agents in the plant–pathogen interactions

Weiberg

Jin

2015

Current Opinion in Plant Biology

Self Cite

124

View full text Add to dashboard Cite

Eukaryotic regulatory small RNAs (sRNAs) that induce RNA interference (RNAi) are involved in a plethora of biological processes, including host immunity and pathogen virulence. In plants, diverse classes of sRNAs contribute to the regulation of host innate immunity. These immune-regulatory sRNAs operate through distinct RNAi pathways that trigger transcriptional or post-transcriptional gene silencing. Similarly, many pathogen-derived sRNAs also regulate pathogen virulence. Remarkably, the influence of regulatory sRNAs is not limited to the individual organism in which they are generated. It can sometimes extend to interacting species from even different kingdoms. There they trigger gene silencing in the interacting organism, a phenomenon called cross-kingdom RNAi. This is exhibited in advanced pathogens and parasites that produce sRNAs to suppress host immunity. Conversely, in host-induced gene silencing (HIGS), diverse plants are engineered to trigger RNAi against pathogens and pests to confer host resistance. Cross-kingdom RNAi opens up a vastly unexplored area of research on mobile sRNAs in the battlefield between hosts and pathogens.

show abstract

Conversations between kingdoms: small RNAs

Cited by 130 publications

References 82 publications

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection

RNA-based disease control as a complementary measure to fight Fusarium fungi through silencing of the azole target Cytochrome P450 Lanosterol C-14 α-Demethylase

Small RNAs — the secret agents in the plant–pathogen interactions

Contact Info

Product

Resources

About